Ultra-processed food consumption, cancer risk and cancer mortality

Detalhes bibliográficos
Autor(a) principal: Chang, Kiara
Data de Publicação: 2023
Outros Autores: Gunter, Marc J., Rauber, Fernanda, Levy, Renata B., Huybrechts, Inge, Kliemann, Nathalie, Millett, Christopher, Vamos, Eszter P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/154063
Resumo: Funding Information: The Cancer Research UK and World Cancer Research Fund.This work was supported by Cancer Research UK C33493/A29678. Funding IIG_FULL_2020_033 was obtained from World Cancer Research Fund (WCRF UK), as part of the World Cancer Research Fund International grant programme. Where authors are identified as personnel of the International Agency for Research on Cancer / World Health Organization, the authors alone are responsible for the views expressed in this article and they do not necessarily represent the decisions, policy or views of the International Agency for Research on Cancer / World Health Organization. FR declares funding from The São Paulo Research Foundation (FAPESP) 16/14302-7 and 18/19820-1. This research has been conducted using the UK Biobank Resource under Application Number 29239. The authors would like to thank the participants of the UK Biobank study. Funding Information: This work was supported by Cancer Research UK C33493 / A29678 . Funding IIG_FULL_2020_033 was obtained from World Cancer Research Fund (WCRF UK), as part of the World Cancer Research Fund International grant programme. Where authors are identified as personnel of the International Agency for Research on Cancer / World Health Organization, the authors alone are responsible for the views expressed in this article and they do not necessarily represent the decisions, policy or views of the International Agency for Research on Cancer / World Health Organization. FR declares funding from The São Paulo Research Foundation (FAPESP) 16/14302-7 and 18/19820-1 . This research has been conducted using the UK Biobank Resource under Application Number 29239. The authors would like to thank the participants of the UK Biobank study. Publisher Copyright: © 2023 The Author(s)
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spelling Ultra-processed food consumption, cancer risk and cancer mortalitya large-scale prospective analysis within the UK BiobankCancer incidenceCancer mortalityProspective cohortUltra-processed foodUnited KingdomMedicine(all)SDG 3 - Good Health and Well-beingFunding Information: The Cancer Research UK and World Cancer Research Fund.This work was supported by Cancer Research UK C33493/A29678. Funding IIG_FULL_2020_033 was obtained from World Cancer Research Fund (WCRF UK), as part of the World Cancer Research Fund International grant programme. Where authors are identified as personnel of the International Agency for Research on Cancer / World Health Organization, the authors alone are responsible for the views expressed in this article and they do not necessarily represent the decisions, policy or views of the International Agency for Research on Cancer / World Health Organization. FR declares funding from The São Paulo Research Foundation (FAPESP) 16/14302-7 and 18/19820-1. This research has been conducted using the UK Biobank Resource under Application Number 29239. The authors would like to thank the participants of the UK Biobank study. Funding Information: This work was supported by Cancer Research UK C33493 / A29678 . Funding IIG_FULL_2020_033 was obtained from World Cancer Research Fund (WCRF UK), as part of the World Cancer Research Fund International grant programme. Where authors are identified as personnel of the International Agency for Research on Cancer / World Health Organization, the authors alone are responsible for the views expressed in this article and they do not necessarily represent the decisions, policy or views of the International Agency for Research on Cancer / World Health Organization. FR declares funding from The São Paulo Research Foundation (FAPESP) 16/14302-7 and 18/19820-1 . This research has been conducted using the UK Biobank Resource under Application Number 29239. The authors would like to thank the participants of the UK Biobank study. Publisher Copyright: © 2023 The Author(s)Background: Global dietary patterns are increasingly dominated by relatively cheap, highly palatable, and ready-to-eat ultra-processed foods (UPFs). However, prospective evidence is limited on cancer development and mortality in relation to UPF consumption. This study examines associations between UPF consumption and risk of cancer and associated mortality for 34 site-specific cancers in a large cohort of British adults. Methods: This study included a prospective cohort of UK Biobank participants (aged 40–69 years) who completed 24-h dietary recalls between 2009 and 2012 (N = 197426, 54.6% women) and were followed up until Jan 31, 2021. Food items consumed were categorised according to their degree of food processing using the NOVA food classification system. Individuals’ UPF consumption was expressed as a percentage of total food intake (g/day). Prospective associations were assessed using multivariable Cox proportional hazards models adjusted for baseline socio-demographic characteristics, smoking status, physical activity, body mass index, alcohol and total energy intake. Findings: The mean UPF consumption was 22.9% (SD 13.3%) in the total diet. During a median follow-up time of 9.8 years, 15,921 individuals developed cancer and 4009 cancer-related deaths occurred. Every 10 percentage points increment in UPF consumption was associated with an increased incidence of overall (hazard ratio, 1.02; 95% CI, 1.01–1.04) and specifically ovarian (1.19; 1.08–1.30) cancer. Furthermore, every 10 percentage points increment in UPF consumption was associated with an increased risk of overall (1.06; 1.03–1.09), ovarian (1.30; 1.13–1.50), and breast (1.16; 1.02–1.32) cancer-related mortality. Interpretation: Our UK-based cohort study suggests that higher UPF consumption may be linked to an increased burden and mortality for overall and certain site-specific cancers especially ovarian cancer in women. Funding: The Cancer Research UK and World Cancer Research Fund.Centro de Investigação em Saúde Pública (CISP/PHRC)Comprehensive Health Research Centre (CHRC) - Pólo ENSPEscola Nacional de Saúde Pública (ENSP)RUNChang, KiaraGunter, Marc J.Rauber, FernandaLevy, Renata B.Huybrechts, IngeKliemann, NathalieMillett, ChristopherVamos, Eszter P.2023-06-16T22:20:25Z2023-022023-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/154063eng2589-5370PURE: 63841468https://doi.org/10.1016/j.eclinm.2023.101840info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:36:34Zoai:run.unl.pt:10362/154063Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:55:29.716129Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Ultra-processed food consumption, cancer risk and cancer mortality
a large-scale prospective analysis within the UK Biobank
title Ultra-processed food consumption, cancer risk and cancer mortality
spellingShingle Ultra-processed food consumption, cancer risk and cancer mortality
Chang, Kiara
Cancer incidence
Cancer mortality
Prospective cohort
Ultra-processed food
United Kingdom
Medicine(all)
SDG 3 - Good Health and Well-being
title_short Ultra-processed food consumption, cancer risk and cancer mortality
title_full Ultra-processed food consumption, cancer risk and cancer mortality
title_fullStr Ultra-processed food consumption, cancer risk and cancer mortality
title_full_unstemmed Ultra-processed food consumption, cancer risk and cancer mortality
title_sort Ultra-processed food consumption, cancer risk and cancer mortality
author Chang, Kiara
author_facet Chang, Kiara
Gunter, Marc J.
Rauber, Fernanda
Levy, Renata B.
Huybrechts, Inge
Kliemann, Nathalie
Millett, Christopher
Vamos, Eszter P.
author_role author
author2 Gunter, Marc J.
Rauber, Fernanda
Levy, Renata B.
Huybrechts, Inge
Kliemann, Nathalie
Millett, Christopher
Vamos, Eszter P.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Centro de Investigação em Saúde Pública (CISP/PHRC)
Comprehensive Health Research Centre (CHRC) - Pólo ENSP
Escola Nacional de Saúde Pública (ENSP)
RUN
dc.contributor.author.fl_str_mv Chang, Kiara
Gunter, Marc J.
Rauber, Fernanda
Levy, Renata B.
Huybrechts, Inge
Kliemann, Nathalie
Millett, Christopher
Vamos, Eszter P.
dc.subject.por.fl_str_mv Cancer incidence
Cancer mortality
Prospective cohort
Ultra-processed food
United Kingdom
Medicine(all)
SDG 3 - Good Health and Well-being
topic Cancer incidence
Cancer mortality
Prospective cohort
Ultra-processed food
United Kingdom
Medicine(all)
SDG 3 - Good Health and Well-being
description Funding Information: The Cancer Research UK and World Cancer Research Fund.This work was supported by Cancer Research UK C33493/A29678. Funding IIG_FULL_2020_033 was obtained from World Cancer Research Fund (WCRF UK), as part of the World Cancer Research Fund International grant programme. Where authors are identified as personnel of the International Agency for Research on Cancer / World Health Organization, the authors alone are responsible for the views expressed in this article and they do not necessarily represent the decisions, policy or views of the International Agency for Research on Cancer / World Health Organization. FR declares funding from The São Paulo Research Foundation (FAPESP) 16/14302-7 and 18/19820-1. This research has been conducted using the UK Biobank Resource under Application Number 29239. The authors would like to thank the participants of the UK Biobank study. Funding Information: This work was supported by Cancer Research UK C33493 / A29678 . Funding IIG_FULL_2020_033 was obtained from World Cancer Research Fund (WCRF UK), as part of the World Cancer Research Fund International grant programme. Where authors are identified as personnel of the International Agency for Research on Cancer / World Health Organization, the authors alone are responsible for the views expressed in this article and they do not necessarily represent the decisions, policy or views of the International Agency for Research on Cancer / World Health Organization. FR declares funding from The São Paulo Research Foundation (FAPESP) 16/14302-7 and 18/19820-1 . This research has been conducted using the UK Biobank Resource under Application Number 29239. The authors would like to thank the participants of the UK Biobank study. Publisher Copyright: © 2023 The Author(s)
publishDate 2023
dc.date.none.fl_str_mv 2023-06-16T22:20:25Z
2023-02
2023-02-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/154063
url http://hdl.handle.net/10362/154063
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2589-5370
PURE: 63841468
https://doi.org/10.1016/j.eclinm.2023.101840
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eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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