Antibiotic Activity Screened by the Rheology of S. aureus Cultures

Detalhes bibliográficos
Autor(a) principal: Portela, Raquel
Data de Publicação: 2020
Outros Autores: Valcovo, Filipe, Almeida, Pedro L., Sobral, Rita G., Leal, Catarina R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/114281
Resumo: UID/CTM/50025/2019 PTDC/BIA-MIC/31645/2017 UIDB/04378/2020 No. POCI-01-0145-FEDER-007728
id RCAP_471b5b121bb87caf6d81db5a5d20c932
oai_identifier_str oai:run.unl.pt:10362/114281
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Antibiotic Activity Screened by the Rheology of S. aureus CulturesantibioticsbactericidalMRSAoxacillinrheologyS. aureusCondensed Matter PhysicsMechanical EngineeringFluid Flow and Transfer ProcessesSDG 3 - Good Health and Well-beingUID/CTM/50025/2019 PTDC/BIA-MIC/31645/2017 UIDB/04378/2020 No. POCI-01-0145-FEDER-007728Multidrug resistant bacteria are one of the most serious public health threats nowadays. How bacteria, as a population, react to the presence of antibiotics is of major importance to the outcome of the chosen treatment. In this study we addressed the impact of oxacillin, a β-lactam, the most clinically relevant class of antibiotics, in the viscosity profile of the methicillin resistant Staphylococcus aureus (MRSA) strain COL. In the first approach, the antibiotic was added, at concentrations under the minimum inhibitory concentration (sub-MIC), to the culture of S. aureus and steady-state shear flow curves were obtained for discrete time points during the bacterial growth, with and without the presence of the antibiotic, showing distinct viscosity progress over time. The different behaviors obtained led us to test the impact of the sub-inhibitory concentration and a concentration that inhibited growth. In the second approach, the viscosity growth curves were measured at a constant shear rate of 10 s-1, over time. The obtained rheological behaviors revealed distinctive characteristics associated to the presence of each concentration of the tested antibiotic. These results bring new insights to the bacteria response to a well-known bacteriolytic antibiotic.UCIBIO - Applied Molecular Biosciences UnitDQ - Departamento de QuímicaCENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)DCM - Departamento de Ciência dos MateriaisRUNPortela, RaquelValcovo, FilipeAlmeida, Pedro L.Sobral, Rita G.Leal, Catarina R.2021-03-22T23:28:20Z2020-062020-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/114281eng2311-5521PURE: 28690047https://doi.org/10.3390/fluids5020076info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:56:55Zoai:run.unl.pt:10362/114281Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:42:29.036264Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Antibiotic Activity Screened by the Rheology of S. aureus Cultures
title Antibiotic Activity Screened by the Rheology of S. aureus Cultures
spellingShingle Antibiotic Activity Screened by the Rheology of S. aureus Cultures
Portela, Raquel
antibiotics
bactericidal
MRSA
oxacillin
rheology
S. aureus
Condensed Matter Physics
Mechanical Engineering
Fluid Flow and Transfer Processes
SDG 3 - Good Health and Well-being
title_short Antibiotic Activity Screened by the Rheology of S. aureus Cultures
title_full Antibiotic Activity Screened by the Rheology of S. aureus Cultures
title_fullStr Antibiotic Activity Screened by the Rheology of S. aureus Cultures
title_full_unstemmed Antibiotic Activity Screened by the Rheology of S. aureus Cultures
title_sort Antibiotic Activity Screened by the Rheology of S. aureus Cultures
author Portela, Raquel
author_facet Portela, Raquel
Valcovo, Filipe
Almeida, Pedro L.
Sobral, Rita G.
Leal, Catarina R.
author_role author
author2 Valcovo, Filipe
Almeida, Pedro L.
Sobral, Rita G.
Leal, Catarina R.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv UCIBIO - Applied Molecular Biosciences Unit
DQ - Departamento de Química
CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)
DCM - Departamento de Ciência dos Materiais
RUN
dc.contributor.author.fl_str_mv Portela, Raquel
Valcovo, Filipe
Almeida, Pedro L.
Sobral, Rita G.
Leal, Catarina R.
dc.subject.por.fl_str_mv antibiotics
bactericidal
MRSA
oxacillin
rheology
S. aureus
Condensed Matter Physics
Mechanical Engineering
Fluid Flow and Transfer Processes
SDG 3 - Good Health and Well-being
topic antibiotics
bactericidal
MRSA
oxacillin
rheology
S. aureus
Condensed Matter Physics
Mechanical Engineering
Fluid Flow and Transfer Processes
SDG 3 - Good Health and Well-being
description UID/CTM/50025/2019 PTDC/BIA-MIC/31645/2017 UIDB/04378/2020 No. POCI-01-0145-FEDER-007728
publishDate 2020
dc.date.none.fl_str_mv 2020-06
2020-06-01T00:00:00Z
2021-03-22T23:28:20Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/114281
url http://hdl.handle.net/10362/114281
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2311-5521
PURE: 28690047
https://doi.org/10.3390/fluids5020076
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799138036276002816

Registros relacionados