Injectable Composite Systems of Gellan Gum:Alginate Microparticles in Pluronic Hydrogels for Bioactive Cargo Controlled Delivery

Detalhes bibliográficos
Autor(a) principal: Carrêlo, Henrique
Data de Publicação: 2022
Outros Autores: Escoval, André R., Soares, Paula I. P., Borges, João P., Cidade, Maria Teresa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/150493
Resumo: projects LA/P/0037/2020. P.S. acknowledges the individual contract CEECIND. 03189.2020. Publisher Copyright: © 2022 by the authors.
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spelling Injectable Composite Systems of Gellan Gum:Alginate Microparticles in Pluronic Hydrogels for Bioactive Cargo Controlled DeliveryOptimization of Hydrogel Composition based on Rheological Behavioralginategellan gumhydrogelsPluronicrheologythermoresponsiveCondensed Matter PhysicsMechanical EngineeringFluid Flow and Transfer Processesprojects LA/P/0037/2020. P.S. acknowledges the individual contract CEECIND. 03189.2020. Publisher Copyright: © 2022 by the authors.Due to the high complexity of some treatments, there is a need to develop drug-delivery systems that can release multiple drugs/bioactive agents at different stages of treatment. In this study, a thermoresponsive injectable dual-release system was developed with gellan gum/alginate microparticles (GG:Alg) within a thermoresponsive Pluronic hydrogel composed of a mixture of Pluronic F127 and F68. The increase in F68 ratio and decrease in F127 lead to higher transition temperatures. The addition of the GG:Alg microparticles decreased the transition temperatures with a linear tendency. In Pluronic aqueous solutions (20 wt.%), the F127:F68 ratios of 16:4 and 17:3 (wt.%:wt.%) and the addition of microparticles (up to 15 wt.%) maintained the sol–gel transition temperatures within a suitable range (between 25 °C and 37 °C). Microparticles did not hinder the injectability of the system in the sol phase. Methylene blue was used as a model drug to evaluate the release mechanisms from microparticles, hydrogel, and composite system. The hydrogel delayed the release of methylene blue from the microparticles. The hydrogel loaded with methylene blue released at a faster rate than the microparticles within the hydrogel, thus demonstrating a dual-release profile.CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)DCM - Departamento de Ciência dos MateriaisRUNCarrêlo, HenriqueEscoval, André R.Soares, Paula I. P.Borges, João P.Cidade, Maria Teresa2023-03-13T22:27:42Z2022-12-062022-12-06T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article16application/pdfhttp://hdl.handle.net/10362/150493engCarrêlo, H., Escoval, A. R., Soares, P. I. P., Borges, J. P., & Cidade, M. T. (2022). Injectable Composite Systems of Gellan Gum:Alginate Microparticles in Pluronic Hydrogels for Bioactive Cargo Controlled Delivery: Optimization of Hydrogel Composition based on Rheological Behavior. FLUIDS, 7(12), [375]. https://doi.org/10.3390/fluids71203752311-5521PURE: 55554746https://doi.org/10.3390/fluids7120375info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:32:28Zoai:run.unl.pt:10362/150493Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:54:09.034553Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Injectable Composite Systems of Gellan Gum:Alginate Microparticles in Pluronic Hydrogels for Bioactive Cargo Controlled Delivery
Optimization of Hydrogel Composition based on Rheological Behavior
title Injectable Composite Systems of Gellan Gum:Alginate Microparticles in Pluronic Hydrogels for Bioactive Cargo Controlled Delivery
spellingShingle Injectable Composite Systems of Gellan Gum:Alginate Microparticles in Pluronic Hydrogels for Bioactive Cargo Controlled Delivery
Carrêlo, Henrique
alginate
gellan gum
hydrogels
Pluronic
rheology
thermoresponsive
Condensed Matter Physics
Mechanical Engineering
Fluid Flow and Transfer Processes
title_short Injectable Composite Systems of Gellan Gum:Alginate Microparticles in Pluronic Hydrogels for Bioactive Cargo Controlled Delivery
title_full Injectable Composite Systems of Gellan Gum:Alginate Microparticles in Pluronic Hydrogels for Bioactive Cargo Controlled Delivery
title_fullStr Injectable Composite Systems of Gellan Gum:Alginate Microparticles in Pluronic Hydrogels for Bioactive Cargo Controlled Delivery
title_full_unstemmed Injectable Composite Systems of Gellan Gum:Alginate Microparticles in Pluronic Hydrogels for Bioactive Cargo Controlled Delivery
title_sort Injectable Composite Systems of Gellan Gum:Alginate Microparticles in Pluronic Hydrogels for Bioactive Cargo Controlled Delivery
author Carrêlo, Henrique
author_facet Carrêlo, Henrique
Escoval, André R.
Soares, Paula I. P.
Borges, João P.
Cidade, Maria Teresa
author_role author
author2 Escoval, André R.
Soares, Paula I. P.
Borges, João P.
Cidade, Maria Teresa
author2_role author
author
author
author
dc.contributor.none.fl_str_mv CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)
DCM - Departamento de Ciência dos Materiais
RUN
dc.contributor.author.fl_str_mv Carrêlo, Henrique
Escoval, André R.
Soares, Paula I. P.
Borges, João P.
Cidade, Maria Teresa
dc.subject.por.fl_str_mv alginate
gellan gum
hydrogels
Pluronic
rheology
thermoresponsive
Condensed Matter Physics
Mechanical Engineering
Fluid Flow and Transfer Processes
topic alginate
gellan gum
hydrogels
Pluronic
rheology
thermoresponsive
Condensed Matter Physics
Mechanical Engineering
Fluid Flow and Transfer Processes
description projects LA/P/0037/2020. P.S. acknowledges the individual contract CEECIND. 03189.2020. Publisher Copyright: © 2022 by the authors.
publishDate 2022
dc.date.none.fl_str_mv 2022-12-06
2022-12-06T00:00:00Z
2023-03-13T22:27:42Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/150493
url http://hdl.handle.net/10362/150493
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Carrêlo, H., Escoval, A. R., Soares, P. I. P., Borges, J. P., & Cidade, M. T. (2022). Injectable Composite Systems of Gellan Gum:Alginate Microparticles in Pluronic Hydrogels for Bioactive Cargo Controlled Delivery: Optimization of Hydrogel Composition based on Rheological Behavior. FLUIDS, 7(12), [375]. https://doi.org/10.3390/fluids7120375
2311-5521
PURE: 55554746
https://doi.org/10.3390/fluids7120375
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 16
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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