Increased frequency of CD25dim CD4+ T-cells in HIV-2 infection, a naturally occurring attenuated form of HIV-1

Detalhes bibliográficos
Autor(a) principal: Foxall, R. B.
Data de Publicação: 2008
Outros Autores: Soares, R. S., Albuquerque, A. S., Cortesão, A. C., Victorino, R. M., Sousa, A. E.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/15878
Resumo: © 2008 Elsevier Inc. All rights reserved.
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spelling Increased frequency of CD25dim CD4+ T-cells in HIV-2 infection, a naturally occurring attenuated form of HIV-1HIV/AIDSHIV-2CD25T-cell subsetsImmune activation© 2008 Elsevier Inc. All rights reserved.The ability to maintain the CD4-memory pool is currently considered one of the main determinants of AIDS progression. Like HIV-1, HIV-2 infection is characterized by progressive hyper-immune activation, yet it is associated with slower rates of CD4-loss and reduced viremia irrespective of disease stage. In contrast to HIV-1, we observed an increased proportion of CD4(+) T-cells expressing CD25 in HIV-2 infected individuals, independent of the degree of CD4-depletion and levels of immune activation. This was due to CD4(+) T-cells expressing an intermediate intensity of CD25, characterized by an increased ability to produce IL-2 and a lack of other regulatory markers. This expansion, unique to HIV-2 seropositive individuals, may relate to an improved ability to replenish their CD4-memory pool, and thus to the better prognosis that characterizes HIV-2 infection. Identification of the underlying mechanisms regulating this population in HIV-1 and HIV-2 infections may provide a rational for novel therapeutic strategies.This work was supported by grants from “Fundação para a Ciência e a Tecnologia” (FCT) and by “Programa Operacional Ciência e Inovação 2010” (POCI2010) to AES. RBF, RSS, ASA, and CSC received scholarships from FCT.ElsevierRepositório da Universidade de LisboaFoxall, R. B.Soares, R. S.Albuquerque, A. S.Cortesão, A. C.Victorino, R. M.Sousa, A. E.2015-02-03T16:41:06Z20082008-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/15878engClinical Immunology (2008) 127, 158–1671521-6616http://dx.doi.org/10.1016/j.clim.2008.01.008metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:02:47Zoai:repositorio.ul.pt:10451/15878Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:37:10.841602Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Increased frequency of CD25dim CD4+ T-cells in HIV-2 infection, a naturally occurring attenuated form of HIV-1
title Increased frequency of CD25dim CD4+ T-cells in HIV-2 infection, a naturally occurring attenuated form of HIV-1
spellingShingle Increased frequency of CD25dim CD4+ T-cells in HIV-2 infection, a naturally occurring attenuated form of HIV-1
Foxall, R. B.
HIV/AIDS
HIV-2
CD25
T-cell subsets
Immune activation
title_short Increased frequency of CD25dim CD4+ T-cells in HIV-2 infection, a naturally occurring attenuated form of HIV-1
title_full Increased frequency of CD25dim CD4+ T-cells in HIV-2 infection, a naturally occurring attenuated form of HIV-1
title_fullStr Increased frequency of CD25dim CD4+ T-cells in HIV-2 infection, a naturally occurring attenuated form of HIV-1
title_full_unstemmed Increased frequency of CD25dim CD4+ T-cells in HIV-2 infection, a naturally occurring attenuated form of HIV-1
title_sort Increased frequency of CD25dim CD4+ T-cells in HIV-2 infection, a naturally occurring attenuated form of HIV-1
author Foxall, R. B.
author_facet Foxall, R. B.
Soares, R. S.
Albuquerque, A. S.
Cortesão, A. C.
Victorino, R. M.
Sousa, A. E.
author_role author
author2 Soares, R. S.
Albuquerque, A. S.
Cortesão, A. C.
Victorino, R. M.
Sousa, A. E.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Foxall, R. B.
Soares, R. S.
Albuquerque, A. S.
Cortesão, A. C.
Victorino, R. M.
Sousa, A. E.
dc.subject.por.fl_str_mv HIV/AIDS
HIV-2
CD25
T-cell subsets
Immune activation
topic HIV/AIDS
HIV-2
CD25
T-cell subsets
Immune activation
description © 2008 Elsevier Inc. All rights reserved.
publishDate 2008
dc.date.none.fl_str_mv 2008
2008-01-01T00:00:00Z
2015-02-03T16:41:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/15878
url http://hdl.handle.net/10451/15878
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Clinical Immunology (2008) 127, 158–167
1521-6616
http://dx.doi.org/10.1016/j.clim.2008.01.008
dc.rights.driver.fl_str_mv metadata only access
info:eu-repo/semantics/openAccess
rights_invalid_str_mv metadata only access
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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