Gestational Exercise Increases Male Offspring’s Maximal Workload Capacity Early in Life

Detalhes bibliográficos
Autor(a) principal: Beleza, Jorge
Data de Publicação: 2022
Outros Autores: Stevanović-Silva, Jelena, Coxito, Pedro, Rocha, Hugo, Santos, Paulo, Ascensão, António, Ramon Torrella, Joan, Magalhães, José
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/8547
Resumo: This article belongs to the Special Issue Targeting Mitochondria in Metabolic Diseases 2.0.
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spelling Gestational Exercise Increases Male Offspring’s Maximal Workload Capacity Early in LifeMitochondriaMaternal ExerciseEpigeneticsPregnancyMicroRNAsGeneticsMetabolic DiseasesDoenças GenéticasThis article belongs to the Special Issue Targeting Mitochondria in Metabolic Diseases 2.0.Mothers' antenatal strategies to improve the intrauterine environment can positively decrease pregnancy-derived intercurrences. By challenging the mother-fetus unit, gestational exercise (GE) favorably modulates deleterious stimuli, such as high-fat, high-sucrose (HFHS) diet-induced adverse consequences for offspring. We aimed to analyze whether GE alters maternal HFHS-consumption effects on male offspring's maximal workload performance (MWP) and in some skeletal muscle (the soleus-SOL and the tibialis anterior-TA) biomarkers associated with mitochondrial biogenesis and oxidative fitness. Infant male Sprague-Dawley rats were divided into experimental groups according to mothers' dietary and/or exercise conditions: offspring of sedentary control diet-fed or HFHS-fed mothers (C-S or HFHS-S, respectively) and of exercised HFHS-fed mothers (HFHS-E). Although maternal HFHS did not significantly alter MWP, offspring from GE dams exhibited increased MWP. Lower SOL AMPk levels in HFHS-S were reverted by GE. SOL PGC-1α, OXPHOS C-I and C-IV subunits remained unaltered by maternal diet, although increased in HFHS-E offspring. Additionally, GE prevented maternal diet-related SOL miR-378a overexpression, while upregulated miR-34a expression. Decreased TA C-IV subunit expression in HFHS-S was reverted in HFHS-E, concomitantly with the downregulation of miR-338. In conclusion, GE in HFHS-fed dams increases the offspring's MWP, which seems to be associated with the intrauterine modulation of SM mitochondrial density and functional markers.Fundação para a Ciência e a Tecnologia, Grant/Award Number: POCI-01- 0145-FEDER 016657-PTDC/DTP- DES/1082/2014, POCI-01-0145-FEDER- 016690-PTDC/DTP-DES/7087/2014, SFRH/BD/129645/2017 and UIDB/00617/2020-base; H2020 Marie Skłodowska-Curie Actions, Grant/Award Number: 722619 and 734719.MDPIRepositório Científico do Instituto Nacional de SaúdeBeleza, JorgeStevanović-Silva, JelenaCoxito, PedroRocha, HugoSantos, PauloAscensão, AntónioRamon Torrella, JoanMagalhães, José2023-03-08T12:39:30Z2022-04-012022-04-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/8547engInt J Mol Sci. 2022 Apr 1;23(7):3916. doi: 10.3390/ijms230739161661-659610.3390/ijms23073916info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:42:38Zoai:repositorio.insa.pt:10400.18/8547Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:43:11.240575Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Gestational Exercise Increases Male Offspring’s Maximal Workload Capacity Early in Life
title Gestational Exercise Increases Male Offspring’s Maximal Workload Capacity Early in Life
spellingShingle Gestational Exercise Increases Male Offspring’s Maximal Workload Capacity Early in Life
Beleza, Jorge
Mitochondria
Maternal Exercise
Epigenetics
Pregnancy
MicroRNAs
Genetics
Metabolic Diseases
Doenças Genéticas
title_short Gestational Exercise Increases Male Offspring’s Maximal Workload Capacity Early in Life
title_full Gestational Exercise Increases Male Offspring’s Maximal Workload Capacity Early in Life
title_fullStr Gestational Exercise Increases Male Offspring’s Maximal Workload Capacity Early in Life
title_full_unstemmed Gestational Exercise Increases Male Offspring’s Maximal Workload Capacity Early in Life
title_sort Gestational Exercise Increases Male Offspring’s Maximal Workload Capacity Early in Life
author Beleza, Jorge
author_facet Beleza, Jorge
Stevanović-Silva, Jelena
Coxito, Pedro
Rocha, Hugo
Santos, Paulo
Ascensão, António
Ramon Torrella, Joan
Magalhães, José
author_role author
author2 Stevanović-Silva, Jelena
Coxito, Pedro
Rocha, Hugo
Santos, Paulo
Ascensão, António
Ramon Torrella, Joan
Magalhães, José
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Beleza, Jorge
Stevanović-Silva, Jelena
Coxito, Pedro
Rocha, Hugo
Santos, Paulo
Ascensão, António
Ramon Torrella, Joan
Magalhães, José
dc.subject.por.fl_str_mv Mitochondria
Maternal Exercise
Epigenetics
Pregnancy
MicroRNAs
Genetics
Metabolic Diseases
Doenças Genéticas
topic Mitochondria
Maternal Exercise
Epigenetics
Pregnancy
MicroRNAs
Genetics
Metabolic Diseases
Doenças Genéticas
description This article belongs to the Special Issue Targeting Mitochondria in Metabolic Diseases 2.0.
publishDate 2022
dc.date.none.fl_str_mv 2022-04-01
2022-04-01T00:00:00Z
2023-03-08T12:39:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/8547
url http://hdl.handle.net/10400.18/8547
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Int J Mol Sci. 2022 Apr 1;23(7):3916. doi: 10.3390/ijms23073916
1661-6596
10.3390/ijms23073916
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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