Composite Central Face Design—An Approach to Achieve Efficient Alginate Microcarriers

Detalhes bibliográficos
Autor(a) principal: Valente, J.F.A.
Data de Publicação: 2019
Outros Autores: Dias, J.R., Sousa, A., Alves, N.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.8/8581
Resumo: Funding: This work was supported by Portuguese Agency for Innovation (PT2020) through the projects (CENTRO-01-0145-FEDER-000014) and (POCI-01-0247-FEDER-017771). It was also supported by the project PAMI – Portuguese Additive Manufacturing Initiative (project nº22158 – SAICT- AAC nº 01/SAICT/2016) and also, by the CDRSP– ID/Multi/04044/2019, funded by the Portuguese Government through FCT/MCTES and co-funded by the European Regional Development Fund through the Partnership Agreement PT2020. This work was also supported by funds from the Health Sciences Research Center (CICS-UBI) through National Funds by FCT - Foundation for Science and Technology (UID / Multi / 00709/2019).
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spelling Composite Central Face Design—An Approach to Achieve Efficient Alginate MicrocarriersAlginateDesign of ExperimentsElectrosprayingMicroparticlesProtein releaseFunding: This work was supported by Portuguese Agency for Innovation (PT2020) through the projects (CENTRO-01-0145-FEDER-000014) and (POCI-01-0247-FEDER-017771). It was also supported by the project PAMI – Portuguese Additive Manufacturing Initiative (project nº22158 – SAICT- AAC nº 01/SAICT/2016) and also, by the CDRSP– ID/Multi/04044/2019, funded by the Portuguese Government through FCT/MCTES and co-funded by the European Regional Development Fund through the Partnership Agreement PT2020. This work was also supported by funds from the Health Sciences Research Center (CICS-UBI) through National Funds by FCT - Foundation for Science and Technology (UID / Multi / 00709/2019).Microparticulated drug delivery systems have been used as promising encapsulation systems for protecting drugs for in vitro and in vivo applications, enhancing its stability, providing an increased surface to volume ratio, reducing adverse effects, and hence an improvement in bioavailability. Among the studied microparticles, there is a rising interest in the research of alginate microparticles for pharmaceutical and biomedical fields confirming its potential to be used as an effective matrix for drug and cell delivery. Moreover, calcium alginate has been one of the most extensively forming microparticles in the presence of divalent cations providing prolonged drug release and suitable mucoadhesive properties. Regarding the above mentioned, in this research work, we intended to produce Ca-alginate micro-vehicles through electrospraying, presenting high encapsulation efficiency (EE%), reduced protein release across the time, reduced swelling effect, and high sphericity coefficient. To quickly achieve these characteristics and to perform an optimal combination among the percentage of alginate and CaCl2, design of Experiments was applied. The obtained model presented to be statistically significant (p-value < 0.05), with a coefficient of determination of 0.9207, 0.9197, 0.9499, and 0.9637 for each output (EE%, release, swelling, and sphericity, respectively). Moreover, the optimal point (4% of alginate and 6.6% of CaCl2) was successfully validated.MDPIIC-OnlineValente, J.F.A.Dias, J.R.Sousa, A.Alves, N.2023-06-13T09:44:15Z2019-112019-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.8/8581engValente, J. F. A., Dias, J. R., Sousa, A., & Alves, N. (2019). Composite Central Face Design—An Approach to Achieve Efficient Alginate Microcarriers. Polymers, 11(12), 1949. https://doi.org/10.3390/polym111219491949https://doi.org/10.3390/polym111219492073-4360info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-17T15:57:39Zoai:iconline.ipleiria.pt:10400.8/8581Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:51:16.512033Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Composite Central Face Design—An Approach to Achieve Efficient Alginate Microcarriers
title Composite Central Face Design—An Approach to Achieve Efficient Alginate Microcarriers
spellingShingle Composite Central Face Design—An Approach to Achieve Efficient Alginate Microcarriers
Valente, J.F.A.
Alginate
Design of Experiments
Electrospraying
Microparticles
Protein release
title_short Composite Central Face Design—An Approach to Achieve Efficient Alginate Microcarriers
title_full Composite Central Face Design—An Approach to Achieve Efficient Alginate Microcarriers
title_fullStr Composite Central Face Design—An Approach to Achieve Efficient Alginate Microcarriers
title_full_unstemmed Composite Central Face Design—An Approach to Achieve Efficient Alginate Microcarriers
title_sort Composite Central Face Design—An Approach to Achieve Efficient Alginate Microcarriers
author Valente, J.F.A.
author_facet Valente, J.F.A.
Dias, J.R.
Sousa, A.
Alves, N.
author_role author
author2 Dias, J.R.
Sousa, A.
Alves, N.
author2_role author
author
author
dc.contributor.none.fl_str_mv IC-Online
dc.contributor.author.fl_str_mv Valente, J.F.A.
Dias, J.R.
Sousa, A.
Alves, N.
dc.subject.por.fl_str_mv Alginate
Design of Experiments
Electrospraying
Microparticles
Protein release
topic Alginate
Design of Experiments
Electrospraying
Microparticles
Protein release
description Funding: This work was supported by Portuguese Agency for Innovation (PT2020) through the projects (CENTRO-01-0145-FEDER-000014) and (POCI-01-0247-FEDER-017771). It was also supported by the project PAMI – Portuguese Additive Manufacturing Initiative (project nº22158 – SAICT- AAC nº 01/SAICT/2016) and also, by the CDRSP– ID/Multi/04044/2019, funded by the Portuguese Government through FCT/MCTES and co-funded by the European Regional Development Fund through the Partnership Agreement PT2020. This work was also supported by funds from the Health Sciences Research Center (CICS-UBI) through National Funds by FCT - Foundation for Science and Technology (UID / Multi / 00709/2019).
publishDate 2019
dc.date.none.fl_str_mv 2019-11
2019-11-01T00:00:00Z
2023-06-13T09:44:15Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.8/8581
url http://hdl.handle.net/10400.8/8581
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Valente, J. F. A., Dias, J. R., Sousa, A., & Alves, N. (2019). Composite Central Face Design—An Approach to Achieve Efficient Alginate Microcarriers. Polymers, 11(12), 1949. https://doi.org/10.3390/polym11121949
1949
https://doi.org/10.3390/polym11121949
2073-4360
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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