Gellan Gum/Alginate Microparticles as Drug Delivery Vehicles

Detalhes bibliográficos
Autor(a) principal: Carrêlo, Henrique
Data de Publicação: 2023
Outros Autores: Cidade, Maria Teresa, Borges, João Paulo, Soares, Paula
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/159630
Resumo: Funding Information: This work is funded by National Funds through the FCT-Fundação para a Ciência e a Tecnologia, I.P., under the scope of the projects UID/50025/2020-2023 and LA/0037/2020 of the Associate Laboratory Institute of Nanostructures, Nanomodelling and Nanofabrication-i3N. P.S. acknowledges the individual contract CEECIND.03189.2020. Publisher Copyright: © 2023 by the authors.
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spelling Gellan Gum/Alginate Microparticles as Drug Delivery VehiclesDOE Production Optimization and Drug Deliveryalginatecoaxial airflowdesign of experimentsgellan gummicroparticlesMolecular MedicinePharmaceutical ScienceDrug DiscoveryFunding Information: This work is funded by National Funds through the FCT-Fundação para a Ciência e a Tecnologia, I.P., under the scope of the projects UID/50025/2020-2023 and LA/0037/2020 of the Associate Laboratory Institute of Nanostructures, Nanomodelling and Nanofabrication-i3N. P.S. acknowledges the individual contract CEECIND.03189.2020. Publisher Copyright: © 2023 by the authors.Gellan gum is a biocompatible and easily accessible polysaccharide with excellent properties to produce microparticles as drug delivery systems. However, the production methods often fail in reproducibility, compromising the translational potential of such systems. In this work, the production of gellan gum-based microparticles was optimized using the coaxial air flow method, and an inexpensive and reproducible production method. A design of experiments was used to identify the main parameters that affect microparticle production and optimization, focusing on diameter and dispersibility. Airflow was the most significant factor for both parameters. Pump flow affected the diameter, while the gellan gum/alginate ratio affected dispersibility. Microparticles were revealed to be sensitive to pH with swelling, degradation, and encapsulation efficiency affected by pH. Using methylene blue as a model drug, higher encapsulation, and swelling indexes were obtained at pH 7.4, while a more pronounced release occurred at pH 6.5. Within PBs solutions, the microparticles endured up to two months. The microparticle release profiles were studied using well-known models, showing a Fickian-type release, but with no alteration by pH. The developed microparticles showed promising results as drug-delivery vehicles sensitive to pH.CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)DCM - Departamento de Ciência dos MateriaisRUNCarrêlo, HenriqueCidade, Maria TeresaBorges, João PauloSoares, Paula2023-11-06T22:10:42Z2023-07-192023-07-19T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article22application/pdfhttp://hdl.handle.net/10362/159630eng1424-8247PURE: 75516526https://doi.org/10.3390/ph16071029info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:42:02Zoai:run.unl.pt:10362/159630Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:57:37.765272Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Gellan Gum/Alginate Microparticles as Drug Delivery Vehicles
DOE Production Optimization and Drug Delivery
title Gellan Gum/Alginate Microparticles as Drug Delivery Vehicles
spellingShingle Gellan Gum/Alginate Microparticles as Drug Delivery Vehicles
Carrêlo, Henrique
alginate
coaxial airflow
design of experiments
gellan gum
microparticles
Molecular Medicine
Pharmaceutical Science
Drug Discovery
title_short Gellan Gum/Alginate Microparticles as Drug Delivery Vehicles
title_full Gellan Gum/Alginate Microparticles as Drug Delivery Vehicles
title_fullStr Gellan Gum/Alginate Microparticles as Drug Delivery Vehicles
title_full_unstemmed Gellan Gum/Alginate Microparticles as Drug Delivery Vehicles
title_sort Gellan Gum/Alginate Microparticles as Drug Delivery Vehicles
author Carrêlo, Henrique
author_facet Carrêlo, Henrique
Cidade, Maria Teresa
Borges, João Paulo
Soares, Paula
author_role author
author2 Cidade, Maria Teresa
Borges, João Paulo
Soares, Paula
author2_role author
author
author
dc.contributor.none.fl_str_mv CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)
DCM - Departamento de Ciência dos Materiais
RUN
dc.contributor.author.fl_str_mv Carrêlo, Henrique
Cidade, Maria Teresa
Borges, João Paulo
Soares, Paula
dc.subject.por.fl_str_mv alginate
coaxial airflow
design of experiments
gellan gum
microparticles
Molecular Medicine
Pharmaceutical Science
Drug Discovery
topic alginate
coaxial airflow
design of experiments
gellan gum
microparticles
Molecular Medicine
Pharmaceutical Science
Drug Discovery
description Funding Information: This work is funded by National Funds through the FCT-Fundação para a Ciência e a Tecnologia, I.P., under the scope of the projects UID/50025/2020-2023 and LA/0037/2020 of the Associate Laboratory Institute of Nanostructures, Nanomodelling and Nanofabrication-i3N. P.S. acknowledges the individual contract CEECIND.03189.2020. Publisher Copyright: © 2023 by the authors.
publishDate 2023
dc.date.none.fl_str_mv 2023-11-06T22:10:42Z
2023-07-19
2023-07-19T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/159630
url http://hdl.handle.net/10362/159630
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1424-8247
PURE: 75516526
https://doi.org/10.3390/ph16071029
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 22
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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