Altered plasma protein profiles in genetic FTD – a GENFI study

Detalhes bibliográficos
Autor(a) principal: Ullgren, Abbe
Data de Publicação: 2023
Outros Autores: Öijerstedt, Linn, Olofsson, Jennie, Bergström, Sofia, Remnestål, Julia, van Swieten, John C., Jiskoot, Lize C., Seelaar, Harro, Borroni, Barbara, Sanchez-Valle, Raquel, Moreno, Fermin, Peakman, Georgia, Pievani, Michela, Pijnenburg, Yolande, Premi, Enrico, Prioni, Sara, Rademakers, Rosa, Redaelli, Veronica, Rinaldi, Daisy, Rittman, Tim, Rogaeva, Ekaterina, Laforce, Robert, Rollin, Adeline, Rosa-Neto, Pedro, Rossi, Giacomina, Rosser, Martin, Scarpini, Elio, Semler, Elisa, Shafei, Rachelle, Shoesmith, Christen, Tábuas-Pereira, Miguel, Tainta, Mikel, Synofzik, Matthis, Taipa, Ricardo, Tang-Wai, David, Thomas, David L., Thompson, Paul, Thonberg, Håkan, Timberlake, Carolyn, Todd, Emily, Van Damme, Philip, Vandenbulcke, Mathieu, Veldsman, Michele, Galimberti, Daniela, Verdelho, Ana, Villanua, Jorge, Warren, Jason, Wilke, Carlo, Woollacott, Ione, Zetterberg, Henrik, Zulaica, Miren, Durães, João, Lima, Marisa, Lemos, João, Rowe, James B., Masellis, Mario, Tartaglia, Maria Carmela, Finger, Elizabeth, Vandenberghe, Rik, De Mendonça, Alexandre, Tirabosch, Pietro, Santana, Isabel, Ducharme, Simon, Butler, Chris R., Gerhard, Alexander, Otto, Markus, Bouzigues, Arabella, Russell, Lucy, Swift, Imogen J., Sogorb-Esteve, Aitana, Heller, Carolin, Rohrer, Jonathan D., Månberg, Anna, Nilsson, Peter, Graff, Caroline, Afonso, Sónia, Almeida, Maria Rosario, Anderl-Straub, Sarah, Andersson, Christin, Antonell, Anna, Arighi, Andrea, Balasa, Mircea, Barandiaran, Myriam, Bargalló, Nuria, Bartha, Robart, Bender, Benjamin, Buratti, Emanuele, Benussi, Luisa, Bertoux, Maxime, Binetti, Giuliano, Black, Sandra, Bocchetta, Martina, Borrego-Ecija, Sergi, Bras, Jose, Bruffaerts, Rose, Cañada, Marta, Cantoni, Valentina, Caroppo, Paola, Cash, David, Castelo-Branco, Miguel, Convery, Rhian, Cope, Thomas, Deramecourt, Vincent, Di Fede, Giuseppe, Díez, Alina, Fenoglio, Chiara, Ferreira, Catarina B., Fox, Nick, Freedman, Morris, Fumagalli, Giorgio, Funkiewiez, Aurélie, Gabilondo, Alazne, Gasparotti, Roberto, Gauthier, Serge, Alberici, Antonella, Giaccone, Giorgio, Gorostidi, Ana, Greaves, Caroline, Guerreiro, Rita, Indakoetxea, Begoña, Jelic, Vesna, Karnath, Hans-Otto, Keren, Ron, Kuchcinski, Gregory, Langheinrich, Tobias, Lebouvier, Thibaud, Leitão, Maria João, Lladó, Albert, Maruta, Carolina, Meeter, Lieke, Miltenberger-Miltenyi, Gabriel, van Minkelen, Rick, Mitchell, Sara, Moore, Katrina, Nicholas, Jennifer, Olives, Jaume, Ourselin, Sebastien, Padovani, Alessandro, Panman, Jessica, Papma, Janne M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/60956
Resumo: © The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
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spelling Altered plasma protein profiles in genetic FTD – a GENFI studyC9orf72Frontotemporal dementiaGRNMAPTNeurodegenerationPlasma biomarkers© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.Background: Plasma biomarkers reflecting the pathology of frontotemporal dementia would add significant value to clinical practice, to the design and implementation of treatment trials as well as our understanding of disease mechanisms. The aim of this study was to explore the levels of multiple plasma proteins in individuals from families with genetic frontotemporal dementia. Methods: Blood samples from 693 participants in the GENetic Frontotemporal Dementia Initiative study were analysed using a multiplexed antibody array targeting 158 proteins. Results: We found 13 elevated proteins in symptomatic mutation carriers, when comparing plasma levels from people diagnosed with genetic FTD to healthy non-mutation controls and 10 proteins that were elevated compared to presymptomatic mutation carriers. Conclusion: We identified plasma proteins with altered levels in symptomatic mutation carriers compared to non-carrier controls as well as to presymptomatic mutation carriers. Further investigations are needed to elucidate their potential as fluid biomarkers of the disease process.Open access funding provided by Karolinska Institute. C.G. received funding from EU Joint Programme—Neurodegenerative Disease Research -Prefrontals Vetenskapsrådet Dnr 529–2014-7504, Vetenskapsrådet 2015–02926, Vetenskapsrådet 2018–02754, the Swedish FTD Inititative-Schörling Foundation, Alzheimer Foundation, Brain Foundation, Dementia Foundation and Region Stockholm ALF-project. PN received funding from KTH Center for Applied Precision Medicine (KCAP) funded by the Erling-Persson Family Foundation, the Swedish FTD Inititative-Schörling Foundation and Åhlén foundation. D.G. received support from the EU Joint Programme—Neurodegenerative Disease Research and the Italian Ministry of Health (PreFrontALS) grant 733051042. E.F. has received funding from a Canadian Institute of Health Research grant #327387. F.M. received funding from the Tau Consortium and the Center for Networked Biomedical Research on Neurodegenerative Disease. J.B.R. has received funding from the Welcome Trust (103838) and is supported by the Cambridge University Centre for Frontotemporal Dementia, the Medical Research Council (SUAG/051 G101400) and the National Institute for Health Research Cambridge Biomedical Research Centre (BRC-1215–20014). J.C.V.S. was supported by the Dioraphte Foundation grant 09–02-03–00, Association for Frontotemporal Dementias Research Grant 2009, Netherlands Organization for Scientific Research grant HCMI 056–13-018, ZonMw Memorabel (Deltaplan Dementie, project number 733 051 042), Alzheimer Nederland and the Bluefield Project. J.D.R. is supported by the Bluefield Project and the National Institute for Health and Care Research University College London Hospitals Biomedical Research Centre, and has received funding from an MRC Clinician Scientist Fellowship (MR/M008525/1) and a Miriam Marks Brain Research UK Senior Fellowship. M.M. has received funding from a Canadian Institute of Health Research operating grant and the Weston Brain Institute and Ontario Brain Institute. M.O. has received funding from Germany’s Federal Ministry of Education and Research (BMBF). R.S-V. is supported by Alzheimer’s Research UK Clinical Research Training Fellowship (ARUK-CRF2017B-2) and has received funding from Fundació Marató de TV3, Spain (grant no. 20143810). R.V. has received funding from the Mady Browaeys Fund for Research into Frontotemporal Dementia. This work was also supported by the EU Joint Programme—Neurodegenerative Disease Research GENFI-PROX grant [2019–02248; to J.D.R., M.O., B.B., C.G., J.C.V.S. and M.S.Springer NatureRepositório da Universidade de LisboaUllgren, AbbeÖijerstedt, LinnOlofsson, JennieBergström, SofiaRemnestål, Juliavan Swieten, John C.Jiskoot, Lize C.Seelaar, HarroBorroni, BarbaraSanchez-Valle, RaquelMoreno, FerminPeakman, GeorgiaPievani, MichelaPijnenburg, YolandePremi, EnricoPrioni, SaraRademakers, RosaRedaelli, VeronicaRinaldi, DaisyRittman, TimRogaeva, EkaterinaLaforce, RobertRollin, AdelineRosa-Neto, PedroRossi, GiacominaRosser, MartinScarpini, ElioSemler, ElisaShafei, RachelleShoesmith, ChristenTábuas-Pereira, MiguelTainta, MikelSynofzik, MatthisTaipa, RicardoTang-Wai, DavidThomas, David L.Thompson, PaulThonberg, HåkanTimberlake, CarolynTodd, EmilyVan Damme, PhilipVandenbulcke, MathieuVeldsman, MicheleGalimberti, DanielaVerdelho, AnaVillanua, JorgeWarren, JasonWilke, CarloWoollacott, IoneZetterberg, HenrikZulaica, MirenDurães, JoãoLima, MarisaLemos, JoãoRowe, James B.Masellis, MarioTartaglia, Maria CarmelaFinger, ElizabethVandenberghe, RikDe Mendonça, AlexandreTirabosch, PietroSantana, IsabelDucharme, SimonButler, Chris R.Gerhard, AlexanderOtto, MarkusBouzigues, ArabellaRussell, LucySwift, Imogen J.Sogorb-Esteve, AitanaHeller, CarolinRohrer, Jonathan D.Månberg, AnnaNilsson, PeterGraff, CarolineAfonso, SóniaAlmeida, Maria RosarioAnderl-Straub, SarahAndersson, ChristinAntonell, AnnaArighi, AndreaBalasa, MirceaBarandiaran, MyriamBargalló, NuriaBartha, RobartBender, BenjaminBuratti, EmanueleBenussi, LuisaBertoux, MaximeBinetti, GiulianoBlack, SandraBocchetta, MartinaBorrego-Ecija, SergiBras, JoseBruffaerts, RoseCañada, MartaCantoni, ValentinaCaroppo, PaolaCash, DavidCastelo-Branco, MiguelConvery, RhianCope, ThomasDeramecourt, VincentDi Fede, GiuseppeDíez, AlinaFenoglio, ChiaraFerreira, Catarina B.Fox, NickFreedman, MorrisFumagalli, GiorgioFunkiewiez, AurélieGabilondo, AlazneGasparotti, RobertoGauthier, SergeAlberici, AntonellaGiaccone, GiorgioGorostidi, AnaGreaves, CarolineGuerreiro, RitaIndakoetxea, BegoñaJelic, VesnaKarnath, Hans-OttoKeren, RonKuchcinski, GregoryLangheinrich, TobiasLebouvier, ThibaudLeitão, Maria JoãoLladó, AlbertMaruta, CarolinaMeeter, LiekeMiltenberger-Miltenyi, Gabrielvan Minkelen, RickMitchell, SaraMoore, KatrinaNicholas, JenniferOlives, JaumeOurselin, SebastienPadovani, AlessandroPanman, JessicaPapma, Janne M.2023-11-28T15:23:45Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/60956engMol Neurodegener. 2023 Nov 15;18(1):8510.1186/s13024-023-00677-61750-1326info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-04T01:18:42Zoai:repositorio.ul.pt:10451/60956Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:40:50.220869Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Altered plasma protein profiles in genetic FTD – a GENFI study
title Altered plasma protein profiles in genetic FTD – a GENFI study
spellingShingle Altered plasma protein profiles in genetic FTD – a GENFI study
Ullgren, Abbe
C9orf72
Frontotemporal dementia
GRN
MAPT
Neurodegeneration
Plasma biomarkers
title_short Altered plasma protein profiles in genetic FTD – a GENFI study
title_full Altered plasma protein profiles in genetic FTD – a GENFI study
title_fullStr Altered plasma protein profiles in genetic FTD – a GENFI study
title_full_unstemmed Altered plasma protein profiles in genetic FTD – a GENFI study
title_sort Altered plasma protein profiles in genetic FTD – a GENFI study
author Ullgren, Abbe
author_facet Ullgren, Abbe
Öijerstedt, Linn
Olofsson, Jennie
Bergström, Sofia
Remnestål, Julia
van Swieten, John C.
Jiskoot, Lize C.
Seelaar, Harro
Borroni, Barbara
Sanchez-Valle, Raquel
Moreno, Fermin
Peakman, Georgia
Pievani, Michela
Pijnenburg, Yolande
Premi, Enrico
Prioni, Sara
Rademakers, Rosa
Redaelli, Veronica
Rinaldi, Daisy
Rittman, Tim
Rogaeva, Ekaterina
Laforce, Robert
Rollin, Adeline
Rosa-Neto, Pedro
Rossi, Giacomina
Rosser, Martin
Scarpini, Elio
Semler, Elisa
Shafei, Rachelle
Shoesmith, Christen
Tábuas-Pereira, Miguel
Tainta, Mikel
Synofzik, Matthis
Taipa, Ricardo
Tang-Wai, David
Thomas, David L.
Thompson, Paul
Thonberg, Håkan
Timberlake, Carolyn
Todd, Emily
Van Damme, Philip
Vandenbulcke, Mathieu
Veldsman, Michele
Galimberti, Daniela
Verdelho, Ana
Villanua, Jorge
Warren, Jason
Wilke, Carlo
Woollacott, Ione
Zetterberg, Henrik
Zulaica, Miren
Durães, João
Lima, Marisa
Lemos, João
Rowe, James B.
Masellis, Mario
Tartaglia, Maria Carmela
Finger, Elizabeth
Vandenberghe, Rik
De Mendonça, Alexandre
Tirabosch, Pietro
Santana, Isabel
Ducharme, Simon
Butler, Chris R.
Gerhard, Alexander
Otto, Markus
Bouzigues, Arabella
Russell, Lucy
Swift, Imogen J.
Sogorb-Esteve, Aitana
Heller, Carolin
Rohrer, Jonathan D.
Månberg, Anna
Nilsson, Peter
Graff, Caroline
Afonso, Sónia
Almeida, Maria Rosario
Anderl-Straub, Sarah
Andersson, Christin
Antonell, Anna
Arighi, Andrea
Balasa, Mircea
Barandiaran, Myriam
Bargalló, Nuria
Bartha, Robart
Bender, Benjamin
Buratti, Emanuele
Benussi, Luisa
Bertoux, Maxime
Binetti, Giuliano
Black, Sandra
Bocchetta, Martina
Borrego-Ecija, Sergi
Bras, Jose
Bruffaerts, Rose
Cañada, Marta
Cantoni, Valentina
Caroppo, Paola
Cash, David
Castelo-Branco, Miguel
Convery, Rhian
Cope, Thomas
Deramecourt, Vincent
Di Fede, Giuseppe
Díez, Alina
Fenoglio, Chiara
Ferreira, Catarina B.
Fox, Nick
Freedman, Morris
Fumagalli, Giorgio
Funkiewiez, Aurélie
Gabilondo, Alazne
Gasparotti, Roberto
Gauthier, Serge
Alberici, Antonella
Giaccone, Giorgio
Gorostidi, Ana
Greaves, Caroline
Guerreiro, Rita
Indakoetxea, Begoña
Jelic, Vesna
Karnath, Hans-Otto
Keren, Ron
Kuchcinski, Gregory
Langheinrich, Tobias
Lebouvier, Thibaud
Leitão, Maria João
Lladó, Albert
Maruta, Carolina
Meeter, Lieke
Miltenberger-Miltenyi, Gabriel
van Minkelen, Rick
Mitchell, Sara
Moore, Katrina
Nicholas, Jennifer
Olives, Jaume
Ourselin, Sebastien
Padovani, Alessandro
Panman, Jessica
Papma, Janne M.
author_role author
author2 Öijerstedt, Linn
Olofsson, Jennie
Bergström, Sofia
Remnestål, Julia
van Swieten, John C.
Jiskoot, Lize C.
Seelaar, Harro
Borroni, Barbara
Sanchez-Valle, Raquel
Moreno, Fermin
Peakman, Georgia
Pievani, Michela
Pijnenburg, Yolande
Premi, Enrico
Prioni, Sara
Rademakers, Rosa
Redaelli, Veronica
Rinaldi, Daisy
Rittman, Tim
Rogaeva, Ekaterina
Laforce, Robert
Rollin, Adeline
Rosa-Neto, Pedro
Rossi, Giacomina
Rosser, Martin
Scarpini, Elio
Semler, Elisa
Shafei, Rachelle
Shoesmith, Christen
Tábuas-Pereira, Miguel
Tainta, Mikel
Synofzik, Matthis
Taipa, Ricardo
Tang-Wai, David
Thomas, David L.
Thompson, Paul
Thonberg, Håkan
Timberlake, Carolyn
Todd, Emily
Van Damme, Philip
Vandenbulcke, Mathieu
Veldsman, Michele
Galimberti, Daniela
Verdelho, Ana
Villanua, Jorge
Warren, Jason
Wilke, Carlo
Woollacott, Ione
Zetterberg, Henrik
Zulaica, Miren
Durães, João
Lima, Marisa
Lemos, João
Rowe, James B.
Masellis, Mario
Tartaglia, Maria Carmela
Finger, Elizabeth
Vandenberghe, Rik
De Mendonça, Alexandre
Tirabosch, Pietro
Santana, Isabel
Ducharme, Simon
Butler, Chris R.
Gerhard, Alexander
Otto, Markus
Bouzigues, Arabella
Russell, Lucy
Swift, Imogen J.
Sogorb-Esteve, Aitana
Heller, Carolin
Rohrer, Jonathan D.
Månberg, Anna
Nilsson, Peter
Graff, Caroline
Afonso, Sónia
Almeida, Maria Rosario
Anderl-Straub, Sarah
Andersson, Christin
Antonell, Anna
Arighi, Andrea
Balasa, Mircea
Barandiaran, Myriam
Bargalló, Nuria
Bartha, Robart
Bender, Benjamin
Buratti, Emanuele
Benussi, Luisa
Bertoux, Maxime
Binetti, Giuliano
Black, Sandra
Bocchetta, Martina
Borrego-Ecija, Sergi
Bras, Jose
Bruffaerts, Rose
Cañada, Marta
Cantoni, Valentina
Caroppo, Paola
Cash, David
Castelo-Branco, Miguel
Convery, Rhian
Cope, Thomas
Deramecourt, Vincent
Di Fede, Giuseppe
Díez, Alina
Fenoglio, Chiara
Ferreira, Catarina B.
Fox, Nick
Freedman, Morris
Fumagalli, Giorgio
Funkiewiez, Aurélie
Gabilondo, Alazne
Gasparotti, Roberto
Gauthier, Serge
Alberici, Antonella
Giaccone, Giorgio
Gorostidi, Ana
Greaves, Caroline
Guerreiro, Rita
Indakoetxea, Begoña
Jelic, Vesna
Karnath, Hans-Otto
Keren, Ron
Kuchcinski, Gregory
Langheinrich, Tobias
Lebouvier, Thibaud
Leitão, Maria João
Lladó, Albert
Maruta, Carolina
Meeter, Lieke
Miltenberger-Miltenyi, Gabriel
van Minkelen, Rick
Mitchell, Sara
Moore, Katrina
Nicholas, Jennifer
Olives, Jaume
Ourselin, Sebastien
Padovani, Alessandro
Panman, Jessica
Papma, Janne M.
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dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Ullgren, Abbe
Öijerstedt, Linn
Olofsson, Jennie
Bergström, Sofia
Remnestål, Julia
van Swieten, John C.
Jiskoot, Lize C.
Seelaar, Harro
Borroni, Barbara
Sanchez-Valle, Raquel
Moreno, Fermin
Peakman, Georgia
Pievani, Michela
Pijnenburg, Yolande
Premi, Enrico
Prioni, Sara
Rademakers, Rosa
Redaelli, Veronica
Rinaldi, Daisy
Rittman, Tim
Rogaeva, Ekaterina
Laforce, Robert
Rollin, Adeline
Rosa-Neto, Pedro
Rossi, Giacomina
Rosser, Martin
Scarpini, Elio
Semler, Elisa
Shafei, Rachelle
Shoesmith, Christen
Tábuas-Pereira, Miguel
Tainta, Mikel
Synofzik, Matthis
Taipa, Ricardo
Tang-Wai, David
Thomas, David L.
Thompson, Paul
Thonberg, Håkan
Timberlake, Carolyn
Todd, Emily
Van Damme, Philip
Vandenbulcke, Mathieu
Veldsman, Michele
Galimberti, Daniela
Verdelho, Ana
Villanua, Jorge
Warren, Jason
Wilke, Carlo
Woollacott, Ione
Zetterberg, Henrik
Zulaica, Miren
Durães, João
Lima, Marisa
Lemos, João
Rowe, James B.
Masellis, Mario
Tartaglia, Maria Carmela
Finger, Elizabeth
Vandenberghe, Rik
De Mendonça, Alexandre
Tirabosch, Pietro
Santana, Isabel
Ducharme, Simon
Butler, Chris R.
Gerhard, Alexander
Otto, Markus
Bouzigues, Arabella
Russell, Lucy
Swift, Imogen J.
Sogorb-Esteve, Aitana
Heller, Carolin
Rohrer, Jonathan D.
Månberg, Anna
Nilsson, Peter
Graff, Caroline
Afonso, Sónia
Almeida, Maria Rosario
Anderl-Straub, Sarah
Andersson, Christin
Antonell, Anna
Arighi, Andrea
Balasa, Mircea
Barandiaran, Myriam
Bargalló, Nuria
Bartha, Robart
Bender, Benjamin
Buratti, Emanuele
Benussi, Luisa
Bertoux, Maxime
Binetti, Giuliano
Black, Sandra
Bocchetta, Martina
Borrego-Ecija, Sergi
Bras, Jose
Bruffaerts, Rose
Cañada, Marta
Cantoni, Valentina
Caroppo, Paola
Cash, David
Castelo-Branco, Miguel
Convery, Rhian
Cope, Thomas
Deramecourt, Vincent
Di Fede, Giuseppe
Díez, Alina
Fenoglio, Chiara
Ferreira, Catarina B.
Fox, Nick
Freedman, Morris
Fumagalli, Giorgio
Funkiewiez, Aurélie
Gabilondo, Alazne
Gasparotti, Roberto
Gauthier, Serge
Alberici, Antonella
Giaccone, Giorgio
Gorostidi, Ana
Greaves, Caroline
Guerreiro, Rita
Indakoetxea, Begoña
Jelic, Vesna
Karnath, Hans-Otto
Keren, Ron
Kuchcinski, Gregory
Langheinrich, Tobias
Lebouvier, Thibaud
Leitão, Maria João
Lladó, Albert
Maruta, Carolina
Meeter, Lieke
Miltenberger-Miltenyi, Gabriel
van Minkelen, Rick
Mitchell, Sara
Moore, Katrina
Nicholas, Jennifer
Olives, Jaume
Ourselin, Sebastien
Padovani, Alessandro
Panman, Jessica
Papma, Janne M.
dc.subject.por.fl_str_mv C9orf72
Frontotemporal dementia
GRN
MAPT
Neurodegeneration
Plasma biomarkers
topic C9orf72
Frontotemporal dementia
GRN
MAPT
Neurodegeneration
Plasma biomarkers
description © The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
publishDate 2023
dc.date.none.fl_str_mv 2023-11-28T15:23:45Z
2023
2023-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/60956
url http://hdl.handle.net/10451/60956
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Mol Neurodegener. 2023 Nov 15;18(1):85
10.1186/s13024-023-00677-6
1750-1326
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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