Cationic surfactants: self-assembly, structure-activity correlation and their biological applications
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/61960 |
Resumo: | The development of biotechnological protocols based on cationic surfactants is a modern trend focusing on the fabrication of antimicrobial and bioimaging agents, supramolecular catalysts, stabilizers of nanoparticles, and especially drug and gene nanocarriers. The main emphasis given to the design of novel ecologically friendly and biocompatible cationic surfactants makes it possible to avoid the drawbacks of nanoformulations preventing their entry to clinical trials. To solve the problem of toxicity various ways are proposed, including the use of mixed composition with nontoxic nonionic surfactants and/or hydrotropic agents, design of amphiphilic compounds bearing natural or cleavable fragments. Essential advantages of cationic surfactants are the structural diversity of their head groups allowing of chemical modification and introduction of desirable moiety to answer the green chemistry criteria. The latter can be exemplified by the design of novel families of ecological friendly cleavable surfactants, with improved biodegradability, amphiphiles with natural fragments, and geminis with low aggregation threshold. Importantly, the development of amphiphilic nanocarriers for drug delivery allows understanding the correlation between the chemical structure of surfactants, their aggregation behavior, and their functional activity. This review focuses on several aspects related to the synthesis of innovative cationic surfactants and their broad biological applications including antimicrobial activity, solubilization of hydrophobic drugs, complexation with DNA, and catalytic effect toward important biochemical reaction. |
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Cationic surfactants: self-assembly, structure-activity correlation and their biological applicationsCationic surfactants1,4-diazabicyclo[2.2.2]octaneSelf-assemblySolubilizationdrug delivery systemsAntimicrobial nanocarriersEngenharia e Tecnologia::Biotecnologia IndustrialScience & TechnologyThe development of biotechnological protocols based on cationic surfactants is a modern trend focusing on the fabrication of antimicrobial and bioimaging agents, supramolecular catalysts, stabilizers of nanoparticles, and especially drug and gene nanocarriers. The main emphasis given to the design of novel ecologically friendly and biocompatible cationic surfactants makes it possible to avoid the drawbacks of nanoformulations preventing their entry to clinical trials. To solve the problem of toxicity various ways are proposed, including the use of mixed composition with nontoxic nonionic surfactants and/or hydrotropic agents, design of amphiphilic compounds bearing natural or cleavable fragments. Essential advantages of cationic surfactants are the structural diversity of their head groups allowing of chemical modification and introduction of desirable moiety to answer the green chemistry criteria. The latter can be exemplified by the design of novel families of ecological friendly cleavable surfactants, with improved biodegradability, amphiphiles with natural fragments, and geminis with low aggregation threshold. Importantly, the development of amphiphilic nanocarriers for drug delivery allows understanding the correlation between the chemical structure of surfactants, their aggregation behavior, and their functional activity. This review focuses on several aspects related to the synthesis of innovative cationic surfactants and their broad biological applications including antimicrobial activity, solubilization of hydrophobic drugs, complexation with DNA, and catalytic effect toward important biochemical reaction.Russian Science Foundation; grant No. 19-73-30012, and from the Portuguese Science and Technology Foundation (FCT) no. SFRH/BPD/101650/2014 granted to SD, SFRH/BD/130555/2017 granted to ARF, and project reference M-ERA-NET/0004/2015 (PAIRED)info:eu-repo/semantics/publishedVersionMDPIUniversidade do MinhoZakharova, Lucia Ya.Pashirova, Tatiana N.Doktorovova, SlavomiraFernandes, Ana R.Sanchez-Lopez, ElenaSilva, Amélia M.Souto, Selma B.Souto, Eliana B.2019-11-062019-11-06T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/61960engZakharova, Lucia Ya.; Pashirova, Tatiana N.; Doktorovova, Slavomira; Fernandes, Ana R.; Sanchez-Lopez, Elena; Silva, Amélia M.; Souto, Selma B.; Souto, Eliana, Cationic surfactants: self-assembly, structure-activity correlation and their biological applications. International Journal of Molecular Sciences, 20(22), 5534, 20191424-67831422-00671661-659610.3390/ijms2022553431698783http://www.mdpi.com/journal/ijmsinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:42:32Zoai:repositorium.sdum.uminho.pt:1822/61960Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:39:48.557523Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Cationic surfactants: self-assembly, structure-activity correlation and their biological applications |
title |
Cationic surfactants: self-assembly, structure-activity correlation and their biological applications |
spellingShingle |
Cationic surfactants: self-assembly, structure-activity correlation and their biological applications Zakharova, Lucia Ya. Cationic surfactants 1,4-diazabicyclo[2.2.2]octane Self-assembly Solubilization drug delivery systems Antimicrobial nanocarriers Engenharia e Tecnologia::Biotecnologia Industrial Science & Technology |
title_short |
Cationic surfactants: self-assembly, structure-activity correlation and their biological applications |
title_full |
Cationic surfactants: self-assembly, structure-activity correlation and their biological applications |
title_fullStr |
Cationic surfactants: self-assembly, structure-activity correlation and their biological applications |
title_full_unstemmed |
Cationic surfactants: self-assembly, structure-activity correlation and their biological applications |
title_sort |
Cationic surfactants: self-assembly, structure-activity correlation and their biological applications |
author |
Zakharova, Lucia Ya. |
author_facet |
Zakharova, Lucia Ya. Pashirova, Tatiana N. Doktorovova, Slavomira Fernandes, Ana R. Sanchez-Lopez, Elena Silva, Amélia M. Souto, Selma B. Souto, Eliana B. |
author_role |
author |
author2 |
Pashirova, Tatiana N. Doktorovova, Slavomira Fernandes, Ana R. Sanchez-Lopez, Elena Silva, Amélia M. Souto, Selma B. Souto, Eliana B. |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Zakharova, Lucia Ya. Pashirova, Tatiana N. Doktorovova, Slavomira Fernandes, Ana R. Sanchez-Lopez, Elena Silva, Amélia M. Souto, Selma B. Souto, Eliana B. |
dc.subject.por.fl_str_mv |
Cationic surfactants 1,4-diazabicyclo[2.2.2]octane Self-assembly Solubilization drug delivery systems Antimicrobial nanocarriers Engenharia e Tecnologia::Biotecnologia Industrial Science & Technology |
topic |
Cationic surfactants 1,4-diazabicyclo[2.2.2]octane Self-assembly Solubilization drug delivery systems Antimicrobial nanocarriers Engenharia e Tecnologia::Biotecnologia Industrial Science & Technology |
description |
The development of biotechnological protocols based on cationic surfactants is a modern trend focusing on the fabrication of antimicrobial and bioimaging agents, supramolecular catalysts, stabilizers of nanoparticles, and especially drug and gene nanocarriers. The main emphasis given to the design of novel ecologically friendly and biocompatible cationic surfactants makes it possible to avoid the drawbacks of nanoformulations preventing their entry to clinical trials. To solve the problem of toxicity various ways are proposed, including the use of mixed composition with nontoxic nonionic surfactants and/or hydrotropic agents, design of amphiphilic compounds bearing natural or cleavable fragments. Essential advantages of cationic surfactants are the structural diversity of their head groups allowing of chemical modification and introduction of desirable moiety to answer the green chemistry criteria. The latter can be exemplified by the design of novel families of ecological friendly cleavable surfactants, with improved biodegradability, amphiphiles with natural fragments, and geminis with low aggregation threshold. Importantly, the development of amphiphilic nanocarriers for drug delivery allows understanding the correlation between the chemical structure of surfactants, their aggregation behavior, and their functional activity. This review focuses on several aspects related to the synthesis of innovative cationic surfactants and their broad biological applications including antimicrobial activity, solubilization of hydrophobic drugs, complexation with DNA, and catalytic effect toward important biochemical reaction. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-11-06 2019-11-06T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/61960 |
url |
http://hdl.handle.net/1822/61960 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Zakharova, Lucia Ya.; Pashirova, Tatiana N.; Doktorovova, Slavomira; Fernandes, Ana R.; Sanchez-Lopez, Elena; Silva, Amélia M.; Souto, Selma B.; Souto, Eliana, Cationic surfactants: self-assembly, structure-activity correlation and their biological applications. International Journal of Molecular Sciences, 20(22), 5534, 2019 1424-6783 1422-0067 1661-6596 10.3390/ijms20225534 31698783 http://www.mdpi.com/journal/ijms |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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