Cell-penetrating peptides: a tool for effective delivery in gene-targeted therapies
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/23253 |
Resumo: | © 2014 International Union of Biochemistry and Molecular Biology |
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Cell-penetrating peptides: a tool for effective delivery in gene-targeted therapiesCell-penetrating peptideGene therapyCancer treatmentDrug delivery© 2014 International Union of Biochemistry and Molecular BiologyThe current landscapes of novel therapeutic approaches rely mostly on gene-targeted technologies, enabling to fight rare genomic diseases, from infections to cancer and hereditary diseases. Although, reaching the action-site for this novel treatments requires to deliver nucleic acids, or other macromolecules into cells, which may pose difficult tasks to pharmaceutical companies. To overcome this technological limitation, a wide variety of vectors have been developed in the past decades and have proven to be successful in delivering various therapeutics. Cell-penetrating peptides (CPP) have been one of the technologies widely studied and have been increasingly used to transport small RNA/DNA, plasmids, antibodies, and nanoparticles into cells. Despite the already proved huge potential that these peptide-based approaches may suggest, few advances have been put to pharmacological or clinical use. This review will describe the origin, development, and usage of CPP to deliver therapeutic agents into cells, with special emphasis on their current application to gene-therapies. Specifically, we will describe the current trials being conducted to treat cancer, gene disorders, and autoimmune diseases using CPP-based therapies.The authors thank Fundação para a Ciência e Tecnologia–Ministério da Educação e Ciência (FCT-MEC, Portugal) [PTDC/QUIBIQ/112929/2009] and Gabinete de Apoio à Investigação Científica, Tecnológica e Inovação (GAPIC–20130028/PEC/BG, 20120006, and 20110007). JMF acknowledges FCT-MEC for fellowship SFRH/BD/70423/2010WileyRepositório da Universidade de LisboaFigueiredo, Inês Rego deFreire, João MiguelFlores, LuísVeiga, Ana SaloméCastanho, Miguel A. R. B.2016-04-05T15:52:28Z20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/23253eng2014 International Union of Biochemistry and Molecular Biology, Volume 66, Number 3, March 2014, Pages 182–1941521-6543DOI 10.1002/iub.1257metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:11:13Zoai:repositorio.ul.pt:10451/23253Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:40:41.557937Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Cell-penetrating peptides: a tool for effective delivery in gene-targeted therapies |
title |
Cell-penetrating peptides: a tool for effective delivery in gene-targeted therapies |
spellingShingle |
Cell-penetrating peptides: a tool for effective delivery in gene-targeted therapies Figueiredo, Inês Rego de Cell-penetrating peptide Gene therapy Cancer treatment Drug delivery |
title_short |
Cell-penetrating peptides: a tool for effective delivery in gene-targeted therapies |
title_full |
Cell-penetrating peptides: a tool for effective delivery in gene-targeted therapies |
title_fullStr |
Cell-penetrating peptides: a tool for effective delivery in gene-targeted therapies |
title_full_unstemmed |
Cell-penetrating peptides: a tool for effective delivery in gene-targeted therapies |
title_sort |
Cell-penetrating peptides: a tool for effective delivery in gene-targeted therapies |
author |
Figueiredo, Inês Rego de |
author_facet |
Figueiredo, Inês Rego de Freire, João Miguel Flores, Luís Veiga, Ana Salomé Castanho, Miguel A. R. B. |
author_role |
author |
author2 |
Freire, João Miguel Flores, Luís Veiga, Ana Salomé Castanho, Miguel A. R. B. |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Figueiredo, Inês Rego de Freire, João Miguel Flores, Luís Veiga, Ana Salomé Castanho, Miguel A. R. B. |
dc.subject.por.fl_str_mv |
Cell-penetrating peptide Gene therapy Cancer treatment Drug delivery |
topic |
Cell-penetrating peptide Gene therapy Cancer treatment Drug delivery |
description |
© 2014 International Union of Biochemistry and Molecular Biology |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014 2014-01-01T00:00:00Z 2016-04-05T15:52:28Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/23253 |
url |
http://hdl.handle.net/10451/23253 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2014 International Union of Biochemistry and Molecular Biology, Volume 66, Number 3, March 2014, Pages 182–194 1521-6543 DOI 10.1002/iub.1257 |
dc.rights.driver.fl_str_mv |
metadata only access info:eu-repo/semantics/openAccess |
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metadata only access |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Wiley |
publisher.none.fl_str_mv |
Wiley |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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