Evaluation of multivariate biomarker indexes application in ecotoxicity tests with marine diatoms exposed to emerging contaminants

Detalhes bibliográficos
Autor(a) principal: Pires, Vanessa
Data de Publicação: 2021
Outros Autores: Novais, Sara C., Lemos, Marco F.L., Fonseca, Vanessa, Duarte, Bernardo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.8/6048
Resumo: The authors would like to thank Fundação para a Ciência e a Tecnologia (FCT) for funding the research via project grants PTDC/MAR-EST/3048/2014 (BIOPHARMA), PTDC/CTAAMB/30056/2017 (OPTOX), UIDB/04292/2020 and UID/MULTI/04046/2019. Work was also funded by the Integrated Programme of SR&TD SmartBioR (reference Centro-01-0145-FEDER000018), co-funded by Centro 2020 program, Portugal 2020, European Union, through the European Regional Development Fund. B. Duarte and V. F. Fonseca were supported by researcher contracts (CEECIND/00511/2017 and DL57/2016/CP1479/CT0024).
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spelling Evaluation of multivariate biomarker indexes application in ecotoxicity tests with marine diatoms exposed to emerging contaminantsAntioxidant enzymesPharmaceutical residuesPesticidesDetergentsIntegrative indexesThe authors would like to thank Fundação para a Ciência e a Tecnologia (FCT) for funding the research via project grants PTDC/MAR-EST/3048/2014 (BIOPHARMA), PTDC/CTAAMB/30056/2017 (OPTOX), UIDB/04292/2020 and UID/MULTI/04046/2019. Work was also funded by the Integrated Programme of SR&TD SmartBioR (reference Centro-01-0145-FEDER000018), co-funded by Centro 2020 program, Portugal 2020, European Union, through the European Regional Development Fund. B. Duarte and V. F. Fonseca were supported by researcher contracts (CEECIND/00511/2017 and DL57/2016/CP1479/CT0024).Worldwide anthropogenic activities result in the production and release of potentially damaging toxic pollutants into ecosystems, thereby jeopardizing their health and continuity. Research studies and biomonitoring programs attend to this emerging problematic by applying and developing statistically relevant indexes that integrate complex biomarker response data to provide a holistic approach, reflecting toxically induced alterations at the organism or population level. Ultimately, indexes allow simple result communications, enhancing policy makers understanding, and contributing to better resource and environmental managing policies. In this study three indexes, the integrated biomarker response index (IBR), the bioeffects assessment index (BAI) and principal components analysis (PCA), were evaluated for their sensitivity in revealing toxically induced stress patterns in cells of the diatom Phaeodactylum tricornutum under contaminant exposure. The set of biomarkers selected for index construction comprised the anti-oxidant enzymes APX, CAT and SOD, and the lipid peroxidation marker TBARS. Several significant correlations with the applied concentration gradients were noticed for all indexes, although IBR excelled for its reliability in delivering statistically significant dose-response patterns for four out of the five tested compounds.MDPIIC-OnlinePires, VanessaNovais, Sara C.Lemos, Marco F.L.Fonseca, VanessaDuarte, Bernardo2021-08-09T14:54:16Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.8/6048engPires, V.L.; Novais, S.C.; Lemos, M.F.L.; Fonseca, V.F.; Duarte, B. Evaluation of Multivariate Biomarker Indexes Application in Ecotoxicity Tests with Marine Diatoms Exposed to Emerging Contaminants. Appl. Sci. 2021, 11, 3878. https://doi.org/10.3390/ app110938782076-341710.3390/ app11093878info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-17T15:52:16Zoai:iconline.ipleiria.pt:10400.8/6048Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:49:23.337746Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Evaluation of multivariate biomarker indexes application in ecotoxicity tests with marine diatoms exposed to emerging contaminants
title Evaluation of multivariate biomarker indexes application in ecotoxicity tests with marine diatoms exposed to emerging contaminants
spellingShingle Evaluation of multivariate biomarker indexes application in ecotoxicity tests with marine diatoms exposed to emerging contaminants
Pires, Vanessa
Antioxidant enzymes
Pharmaceutical residues
Pesticides
Detergents
Integrative indexes
title_short Evaluation of multivariate biomarker indexes application in ecotoxicity tests with marine diatoms exposed to emerging contaminants
title_full Evaluation of multivariate biomarker indexes application in ecotoxicity tests with marine diatoms exposed to emerging contaminants
title_fullStr Evaluation of multivariate biomarker indexes application in ecotoxicity tests with marine diatoms exposed to emerging contaminants
title_full_unstemmed Evaluation of multivariate biomarker indexes application in ecotoxicity tests with marine diatoms exposed to emerging contaminants
title_sort Evaluation of multivariate biomarker indexes application in ecotoxicity tests with marine diatoms exposed to emerging contaminants
author Pires, Vanessa
author_facet Pires, Vanessa
Novais, Sara C.
Lemos, Marco F.L.
Fonseca, Vanessa
Duarte, Bernardo
author_role author
author2 Novais, Sara C.
Lemos, Marco F.L.
Fonseca, Vanessa
Duarte, Bernardo
author2_role author
author
author
author
dc.contributor.none.fl_str_mv IC-Online
dc.contributor.author.fl_str_mv Pires, Vanessa
Novais, Sara C.
Lemos, Marco F.L.
Fonseca, Vanessa
Duarte, Bernardo
dc.subject.por.fl_str_mv Antioxidant enzymes
Pharmaceutical residues
Pesticides
Detergents
Integrative indexes
topic Antioxidant enzymes
Pharmaceutical residues
Pesticides
Detergents
Integrative indexes
description The authors would like to thank Fundação para a Ciência e a Tecnologia (FCT) for funding the research via project grants PTDC/MAR-EST/3048/2014 (BIOPHARMA), PTDC/CTAAMB/30056/2017 (OPTOX), UIDB/04292/2020 and UID/MULTI/04046/2019. Work was also funded by the Integrated Programme of SR&TD SmartBioR (reference Centro-01-0145-FEDER000018), co-funded by Centro 2020 program, Portugal 2020, European Union, through the European Regional Development Fund. B. Duarte and V. F. Fonseca were supported by researcher contracts (CEECIND/00511/2017 and DL57/2016/CP1479/CT0024).
publishDate 2021
dc.date.none.fl_str_mv 2021-08-09T14:54:16Z
2021
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.8/6048
url http://hdl.handle.net/10400.8/6048
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Pires, V.L.; Novais, S.C.; Lemos, M.F.L.; Fonseca, V.F.; Duarte, B. Evaluation of Multivariate Biomarker Indexes Application in Ecotoxicity Tests with Marine Diatoms Exposed to Emerging Contaminants. Appl. Sci. 2021, 11, 3878. https://doi.org/10.3390/ app11093878
2076-3417
10.3390/ app11093878
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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