Comparison of the voltammetric behavior of metronidazole at a DNA-modified glassy carbon electrode, a mercury thin film electrode and a glassy carbon electrode
Autor(a) principal: | |
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Data de Publicação: | 1997 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/8302 https://doi.org/10.1002/elan.1140090204 |
Resumo: | The electroanalytical performance at three electrodes: DNA-modified galssy carbon electrode, mercury thin film electrode and glassy carbon electrode, for the study of the electrochemical reduction of metronidazole is compared. All three electrodes showed a similar trend in the reduction mechanism for metronidazole, depenent on pH in the acid and neutral region and independent in alkaline media, although there was a shift in the peak potentials to more negative values when a bare glassy carbon electrode was used compared to the other two. Besides the advantage of using a solid electrode for the reduction of metronidazole, the DNA-modified galssy carbon electrode enables a lower detection limit of 1.0 muM owing to the preconecentration of the drug on the electrode surface, which is not the case for the mercury thin film or bare glassy carbon electrodes. |
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Comparison of the voltammetric behavior of metronidazole at a DNA-modified glassy carbon electrode, a mercury thin film electrode and a glassy carbon electrodeThe electroanalytical performance at three electrodes: DNA-modified galssy carbon electrode, mercury thin film electrode and glassy carbon electrode, for the study of the electrochemical reduction of metronidazole is compared. All three electrodes showed a similar trend in the reduction mechanism for metronidazole, depenent on pH in the acid and neutral region and independent in alkaline media, although there was a shift in the peak potentials to more negative values when a bare glassy carbon electrode was used compared to the other two. Besides the advantage of using a solid electrode for the reduction of metronidazole, the DNA-modified galssy carbon electrode enables a lower detection limit of 1.0 muM owing to the preconecentration of the drug on the electrode surface, which is not the case for the mercury thin film or bare glassy carbon electrodes.1997info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/8302http://hdl.handle.net/10316/8302https://doi.org/10.1002/elan.1140090204engElectroanalysis. 9:2 (1997) 110-114Brett, Ana Maria OliveiraSerrano, Sílvia H. P.Gutz, Ivano G. R.La-Scalea, Mauro A.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2021-10-26T13:12:00Zoai:estudogeral.uc.pt:10316/8302Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:01:39.012656Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Comparison of the voltammetric behavior of metronidazole at a DNA-modified glassy carbon electrode, a mercury thin film electrode and a glassy carbon electrode |
title |
Comparison of the voltammetric behavior of metronidazole at a DNA-modified glassy carbon electrode, a mercury thin film electrode and a glassy carbon electrode |
spellingShingle |
Comparison of the voltammetric behavior of metronidazole at a DNA-modified glassy carbon electrode, a mercury thin film electrode and a glassy carbon electrode Brett, Ana Maria Oliveira |
title_short |
Comparison of the voltammetric behavior of metronidazole at a DNA-modified glassy carbon electrode, a mercury thin film electrode and a glassy carbon electrode |
title_full |
Comparison of the voltammetric behavior of metronidazole at a DNA-modified glassy carbon electrode, a mercury thin film electrode and a glassy carbon electrode |
title_fullStr |
Comparison of the voltammetric behavior of metronidazole at a DNA-modified glassy carbon electrode, a mercury thin film electrode and a glassy carbon electrode |
title_full_unstemmed |
Comparison of the voltammetric behavior of metronidazole at a DNA-modified glassy carbon electrode, a mercury thin film electrode and a glassy carbon electrode |
title_sort |
Comparison of the voltammetric behavior of metronidazole at a DNA-modified glassy carbon electrode, a mercury thin film electrode and a glassy carbon electrode |
author |
Brett, Ana Maria Oliveira |
author_facet |
Brett, Ana Maria Oliveira Serrano, Sílvia H. P. Gutz, Ivano G. R. La-Scalea, Mauro A. |
author_role |
author |
author2 |
Serrano, Sílvia H. P. Gutz, Ivano G. R. La-Scalea, Mauro A. |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Brett, Ana Maria Oliveira Serrano, Sílvia H. P. Gutz, Ivano G. R. La-Scalea, Mauro A. |
description |
The electroanalytical performance at three electrodes: DNA-modified galssy carbon electrode, mercury thin film electrode and glassy carbon electrode, for the study of the electrochemical reduction of metronidazole is compared. All three electrodes showed a similar trend in the reduction mechanism for metronidazole, depenent on pH in the acid and neutral region and independent in alkaline media, although there was a shift in the peak potentials to more negative values when a bare glassy carbon electrode was used compared to the other two. Besides the advantage of using a solid electrode for the reduction of metronidazole, the DNA-modified galssy carbon electrode enables a lower detection limit of 1.0 muM owing to the preconecentration of the drug on the electrode surface, which is not the case for the mercury thin film or bare glassy carbon electrodes. |
publishDate |
1997 |
dc.date.none.fl_str_mv |
1997 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/8302 http://hdl.handle.net/10316/8302 https://doi.org/10.1002/elan.1140090204 |
url |
http://hdl.handle.net/10316/8302 https://doi.org/10.1002/elan.1140090204 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Electroanalysis. 9:2 (1997) 110-114 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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