Electrochemical determination of carboplatin in serum using a DNA-modified glassy carbon electrode

Detalhes bibliográficos
Autor(a) principal: Brett, Ana Maria Oliveira
Data de Publicação: 1996
Outros Autores: Serrano, Sílvia H. P., Macedo, Tice A., Raimundo, Dulce, Marques, M. Helena, La-Scalea, Mauro A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/8305
https://doi.org/10.1002/elan.1140081104
Resumo: An electrochemical method for the determination of the anticancer platinum drug carboplatin using a DNA-modified electrode was developed. This electrode was successfully used for the electrochemical determination of carboplatin in serum samples of patients with ovarian cancer undergoing treatment. The electrochemical results clearly demonstrated that, for low concentrations, carboplatin interacts preferentially with adenine rather than guanine groups in the DNA and they can contribute to clarifying the mechanisms of interaction of platinum anticancer drugs with DNA. The pharmacokinetics corresponding to the administration of the drug was followed electrochemically and the detection limit in serum samples was 5.7 × 10 -6M. Due to a similar mechanism of reaction with DNA other platinum anticancer drugs can be determined by this method.
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spelling Electrochemical determination of carboplatin in serum using a DNA-modified glassy carbon electrodeAn electrochemical method for the determination of the anticancer platinum drug carboplatin using a DNA-modified electrode was developed. This electrode was successfully used for the electrochemical determination of carboplatin in serum samples of patients with ovarian cancer undergoing treatment. The electrochemical results clearly demonstrated that, for low concentrations, carboplatin interacts preferentially with adenine rather than guanine groups in the DNA and they can contribute to clarifying the mechanisms of interaction of platinum anticancer drugs with DNA. The pharmacokinetics corresponding to the administration of the drug was followed electrochemically and the detection limit in serum samples was 5.7 × 10 -6M. Due to a similar mechanism of reaction with DNA other platinum anticancer drugs can be determined by this method.1996info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/8305http://hdl.handle.net/10316/8305https://doi.org/10.1002/elan.1140081104engElectroanalysis. 8:11 (1996) 992-995Brett, Ana Maria OliveiraSerrano, Sílvia H. P.Macedo, Tice A.Raimundo, DulceMarques, M. HelenaLa-Scalea, Mauro A.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2021-09-22T09:27:07Zoai:estudogeral.uc.pt:10316/8305Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:01:26.510475Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Electrochemical determination of carboplatin in serum using a DNA-modified glassy carbon electrode
title Electrochemical determination of carboplatin in serum using a DNA-modified glassy carbon electrode
spellingShingle Electrochemical determination of carboplatin in serum using a DNA-modified glassy carbon electrode
Brett, Ana Maria Oliveira
title_short Electrochemical determination of carboplatin in serum using a DNA-modified glassy carbon electrode
title_full Electrochemical determination of carboplatin in serum using a DNA-modified glassy carbon electrode
title_fullStr Electrochemical determination of carboplatin in serum using a DNA-modified glassy carbon electrode
title_full_unstemmed Electrochemical determination of carboplatin in serum using a DNA-modified glassy carbon electrode
title_sort Electrochemical determination of carboplatin in serum using a DNA-modified glassy carbon electrode
author Brett, Ana Maria Oliveira
author_facet Brett, Ana Maria Oliveira
Serrano, Sílvia H. P.
Macedo, Tice A.
Raimundo, Dulce
Marques, M. Helena
La-Scalea, Mauro A.
author_role author
author2 Serrano, Sílvia H. P.
Macedo, Tice A.
Raimundo, Dulce
Marques, M. Helena
La-Scalea, Mauro A.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Brett, Ana Maria Oliveira
Serrano, Sílvia H. P.
Macedo, Tice A.
Raimundo, Dulce
Marques, M. Helena
La-Scalea, Mauro A.
description An electrochemical method for the determination of the anticancer platinum drug carboplatin using a DNA-modified electrode was developed. This electrode was successfully used for the electrochemical determination of carboplatin in serum samples of patients with ovarian cancer undergoing treatment. The electrochemical results clearly demonstrated that, for low concentrations, carboplatin interacts preferentially with adenine rather than guanine groups in the DNA and they can contribute to clarifying the mechanisms of interaction of platinum anticancer drugs with DNA. The pharmacokinetics corresponding to the administration of the drug was followed electrochemically and the detection limit in serum samples was 5.7 × 10 -6M. Due to a similar mechanism of reaction with DNA other platinum anticancer drugs can be determined by this method.
publishDate 1996
dc.date.none.fl_str_mv 1996
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/8305
http://hdl.handle.net/10316/8305
https://doi.org/10.1002/elan.1140081104
url http://hdl.handle.net/10316/8305
https://doi.org/10.1002/elan.1140081104
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Electroanalysis. 8:11 (1996) 992-995
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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