Host AMPK Is a modulator of Plasmodium liver infection

Detalhes bibliográficos
Autor(a) principal: Ruivo, Margarida
Data de Publicação: 2016
Outros Autores: Vera, Iset, Sales Dias, Joana, Meireles, Patricia, Gural, Nil, Bhatia, Sangeeta N., Mota, Maria M., Mancio-Silva, Liliana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/53069
Resumo: © 2016 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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spelling Host AMPK Is a modulator of Plasmodium liver infection© 2016 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).Manipulation of the master regulator of energy homeostasis AMP-activated protein kinase (AMPK) activity is a strategy used by many intracellular pathogens for successful replication. Infection by most pathogens leads to an activation of host AMPK activity due to the energetic demands placed on the infected cell. Here, we demonstrate that the opposite is observed in cells infected with rodent malaria parasites. Indeed, AMPK activity upon the infection of hepatic cells is suppressed and dispensable for successful infection. By contrast, an overactive AMPK is deleterious to intracellular growth and replication of different Plasmodium spp., including the human malaria parasite, P. falciparum. The negative impact of host AMPK activity on infection was further confirmed in mice under conditions that activate its function. Overall, this work establishes the role of host AMPK signaling as a suppressive pathway of Plasmodium hepatic infection and as a potential target for host-based antimalarial interventions.This work was supported by European Commission (FP7/2007-2013) grant agreement No. 242095 (EVIMalaR) to L.M.-S. and M.M.M.; and Fundação para a Ciência e Tecnologia (Portugal) through grants PTDC/SAU-MET/118199/2010 and EXCL/IMI-MIC/0056/2012 to L.M.-S. and M.M.M., respectively. M.M.M. was also supported by the ERC (agreement No. 311502). I.M.V. was sponsored by EMBO LTF 712-2012 and NIH NRSA 5F32AI104252 fellowships.ElsevierRepositório da Universidade de LisboaRuivo, MargaridaVera, IsetSales Dias, JoanaMeireles, PatriciaGural, NilBhatia, Sangeeta N.Mota, Maria M.Mancio-Silva, Liliana2022-05-19T14:22:30Z20162016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/53069engCell Rep. 2016 Sep 6;16(10):2539-25452639-185610.1016/j.celrep.2016.08.0012211-1247info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-20T18:14:28Zoai:repositorio.ul.pt:10451/53069Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-20T18:14:28Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Host AMPK Is a modulator of Plasmodium liver infection
title Host AMPK Is a modulator of Plasmodium liver infection
spellingShingle Host AMPK Is a modulator of Plasmodium liver infection
Ruivo, Margarida
title_short Host AMPK Is a modulator of Plasmodium liver infection
title_full Host AMPK Is a modulator of Plasmodium liver infection
title_fullStr Host AMPK Is a modulator of Plasmodium liver infection
title_full_unstemmed Host AMPK Is a modulator of Plasmodium liver infection
title_sort Host AMPK Is a modulator of Plasmodium liver infection
author Ruivo, Margarida
author_facet Ruivo, Margarida
Vera, Iset
Sales Dias, Joana
Meireles, Patricia
Gural, Nil
Bhatia, Sangeeta N.
Mota, Maria M.
Mancio-Silva, Liliana
author_role author
author2 Vera, Iset
Sales Dias, Joana
Meireles, Patricia
Gural, Nil
Bhatia, Sangeeta N.
Mota, Maria M.
Mancio-Silva, Liliana
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Ruivo, Margarida
Vera, Iset
Sales Dias, Joana
Meireles, Patricia
Gural, Nil
Bhatia, Sangeeta N.
Mota, Maria M.
Mancio-Silva, Liliana
description © 2016 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-01-01T00:00:00Z
2022-05-19T14:22:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/53069
url http://hdl.handle.net/10451/53069
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Cell Rep. 2016 Sep 6;16(10):2539-2545
2639-1856
10.1016/j.celrep.2016.08.001
2211-1247
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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