The antitumor activity of a lead thioxanthone is associated with alterations in cholesterol localization

• Autor(a) principal: Lima, Raquel T.
• Data de Publicação: 2018
• Outros Autores: Sousa, Diana, Gomes, Ana Sara, Mendes, Nuno, Matthiesen, Rune, Pedro, Madalena, Marques, Franklim, Pinto, Madalena M., Sousa, Emília, Helena Vasconcelos, M.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: https://doi.org/10.3390/molecules23123301
• topic: Antitumor activity; Cholesterol localization; Non-small cell lung cancer; Rags; Thioxanthones; Tumor xenografts; Analytical Chemistry; Chemistry (miscellaneous); Molecular Medicine; Pharmaceutical Science; Drug Discovery; Physical and Theoretical Chemistry; Organic Chemistry; SDG 3 - Good Health and Well-being

IPATIMUP integrates the i3S Research Unit, which is partially supported by FCT, the Portuguese Foundation for Science and Technology. This work is funded by FEDER funds through the Operational Programme for Competitiveness Factors-COMPETE and National Funds through the FCT-Foundation for Science and Technology, under the projects "PEst-C/SAU/LA0003/2013", ERDF, programme PT2020-Contributos para o reforco da capacidade do IPATIMUP enquanto actor do sistema regional de inovacao" and NORTE-07-0162-FEDER-000067-Reforco e consolidacao da capacidade infraestrutural do IPATIMUP para o sistema regional de inovacao", both supported by Programa Operacional Regional do Norte (ON.2-O Novo Norte), through FEDER funds under the Quadro de Referencia Estrategico Nacional (QREN). This work was also financed by FEDER-Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020-Operacional Programme for Competitiveness and Internationalisation (POCI), Portugal 2020, and by Portuguese funds through FCT-Fundacao para a Ciencia e a Tecnologia/Ministerio da Ciencia, Tecnologia e Inovacao in the framework of the project "Institute for Research and Innovation in Health Sciences" (POCI-01-0145-FEDER-007274). This work was also supported through national funds provided by FCT/MCTES-Foundation for Science and Technology from the Minister of Science, Technology and Higher Education (PIDDAC) and European Regional Development Fund (ERDF) through the COMPETE-Programa Operacional Factores de Competitividade (POFC) programme, under the Strategic Funding UID/Multi/04423/2013, in the framework of the programme PT2020.