Dysphagia predicts poor outcome in late-stage Parkinson's disease

Detalhes bibliográficos
Autor(a) principal: Fabbri, Margherita
Data de Publicação: 2019
Outros Autores: Coelho, Miguel, Abreu, Daisy, Guedes, Leonor Correia, Rosa, Mario M., Godinho, Catarina, Cardoso, Rita, Guimarães, Isabel, Antonini, Angelo, Zibetti, Maurizio, Lopiano, Leonardo, Ferreira, Joaquim J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.26/29986
Resumo: Article under a CC-BY-NC-ND license.
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spelling Dysphagia predicts poor outcome in late-stage Parkinson's diseaseDementiaDysphagiaLate stageMortalityParkinson's diseaseArticle under a CC-BY-NC-ND license."BACKGROUND: Few data exist on the rate of clinical progression for Parkinson's disease (PD) patients who have entered a late stage of the disease. OBJECTIVE: Study the clinical progression of a late-stage PD (LSPD) population over one year follow-up. METHODS: 50 LSPD patients (Schwab and England ADL Scale <50 or Hoehn Yahr Stage >3 in MED ON) underwent an extensive clinical assessment at baseline and after one year and an acute levodopa test at baseline. RESULTS: Mean age of LSPD patients (female 46%) was 77.5 ± 5.9 years and mean disease duration was 15.5 ± 6.5 years. At baseline, 76% had levodopa-induced motor complications (MC), usually non-troublesome, 68% were demented, 54% had psychosis and 68% depression. Caregiver distress was high. l-dopa responsiveness was mild (18% ± 12 of improvement on MDS-UPDRS-III). After one-year, 20% of the patients were dead, institutionalized or HY 5. MDS-UPDRS-motor mean score worsened 7.2 ± 10.3 points although there was heterogeneity between patients, and there was a global worsening of non-motor symptoms, mostly in cognition/mood, urinary and gastrointestinal domains. Nevertheless, MC improved despite similar levodopa equivalent dose. Functional independence and quality of life worsened. Dysphagia severity at baseline predicted a poor outcome (death, institutionalization or HY 5) (Hazard ratio 2.3, 95% CI 1.12-4.4; p = 0.01), whereas magnitude of l-dopa response of LSPD patients did not. CONCLUSIONS: LSPD patients still present a significant, although heterogeneous, motor and non-motor progression over 1 year. Dysphagia severity predicts the occurrence of additional disease severity milestones and its management must be prioritized."ElsevierRepositório ComumFabbri, MargheritaCoelho, MiguelAbreu, DaisyGuedes, Leonor CorreiaRosa, Mario M.Godinho, CatarinaCardoso, RitaGuimarães, IsabelAntonini, AngeloZibetti, MaurizioLopiano, LeonardoFerreira, Joaquim J.2020-08-31T00:30:15Z2019-07-01T00:00:00Z2019-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.26/29986engFabbri M, Coelho M, Abreu D, Guedes LC, Rosa MM, Godinho C, Cardoso R, Guimaraes I, Antonini A, Zibetti M, Lopiano L, Ferreira JJ, Dysphagia predicts poor outcome in late- stage Parkinson's disease, Parkinsonism and Related Disorders (2019), doi: https://doi.org/10.1016/j.parkreldis.2019.02.0431353-802010.1016/ j.parkreldis.2019.02.043info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-10-06T14:53:47Zoai:comum.rcaap.pt:10400.26/29986Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:09:34.671486Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Dysphagia predicts poor outcome in late-stage Parkinson's disease
title Dysphagia predicts poor outcome in late-stage Parkinson's disease
spellingShingle Dysphagia predicts poor outcome in late-stage Parkinson's disease
Fabbri, Margherita
Dementia
Dysphagia
Late stage
Mortality
Parkinson's disease
title_short Dysphagia predicts poor outcome in late-stage Parkinson's disease
title_full Dysphagia predicts poor outcome in late-stage Parkinson's disease
title_fullStr Dysphagia predicts poor outcome in late-stage Parkinson's disease
title_full_unstemmed Dysphagia predicts poor outcome in late-stage Parkinson's disease
title_sort Dysphagia predicts poor outcome in late-stage Parkinson's disease
author Fabbri, Margherita
author_facet Fabbri, Margherita
Coelho, Miguel
Abreu, Daisy
Guedes, Leonor Correia
Rosa, Mario M.
Godinho, Catarina
Cardoso, Rita
Guimarães, Isabel
Antonini, Angelo
Zibetti, Maurizio
Lopiano, Leonardo
Ferreira, Joaquim J.
author_role author
author2 Coelho, Miguel
Abreu, Daisy
Guedes, Leonor Correia
Rosa, Mario M.
Godinho, Catarina
Cardoso, Rita
Guimarães, Isabel
Antonini, Angelo
Zibetti, Maurizio
Lopiano, Leonardo
Ferreira, Joaquim J.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Comum
dc.contributor.author.fl_str_mv Fabbri, Margherita
Coelho, Miguel
Abreu, Daisy
Guedes, Leonor Correia
Rosa, Mario M.
Godinho, Catarina
Cardoso, Rita
Guimarães, Isabel
Antonini, Angelo
Zibetti, Maurizio
Lopiano, Leonardo
Ferreira, Joaquim J.
dc.subject.por.fl_str_mv Dementia
Dysphagia
Late stage
Mortality
Parkinson's disease
topic Dementia
Dysphagia
Late stage
Mortality
Parkinson's disease
description Article under a CC-BY-NC-ND license.
publishDate 2019
dc.date.none.fl_str_mv 2019-07-01T00:00:00Z
2019-07-01T00:00:00Z
2020-08-31T00:30:15Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.26/29986
url http://hdl.handle.net/10400.26/29986
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Fabbri M, Coelho M, Abreu D, Guedes LC, Rosa MM, Godinho C, Cardoso R, Guimaraes I, Antonini A, Zibetti M, Lopiano L, Ferreira JJ, Dysphagia predicts poor outcome in late- stage Parkinson's disease, Parkinsonism and Related Disorders (2019), doi: https://doi.org/10.1016/j.parkreldis.2019.02.043
1353-8020
10.1016/ j.parkreldis.2019.02.043
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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