Current approach to endometriosis: pathogenic and therapeutic implications

• Autor(a) principal: Victor Santos Brito, Paulo
• Data de Publicação: 2024
• Outros Autores: Lavinas Lúcio da Silva, Caroline, Genielly Camilo Bezerra, Evelyn, Wolbeck Jungermann, Priscila, Vytor Cardoso Nobre, Paulo, Clemente Costa d’Oliveira , Ruane, Andrade Brandão , Camila, Vitória Sousa Gois, Yasmin, da Silva Santos , Lorena, Carolina Dória de Melo, Ana, da Silva Peixoto, Morgan, Antônio Gomes de Oliveira , Marcos
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Brazilian Journal of Implantology and Health Sciences
• DOI: 10.36557/2674-8169.2024v6n4p1730-1742
• Texto Completo: https://bjihs.emnuvens.com.br/bjihs/article/view/1933
• topic: endometriose; patogênese; tratamento; manejo.; endometriosis; pathogenesis; treatment; management.

Introduction: Endometriosis is a condition characterized by the ectopic presence of functional endometrial tissue, that is, similar to the endometrium, outside the uterine cavity. These implants can be found in various regions of the pelvis, such as the ovaries, uterosacral ligaments, pelvic peritoneum and other adjacent organs. Objective: To evaluate the pathogenesis and management of endometriosis. Methodology: This is a bibliographic review that included original articles and systematic reviews in English and Portuguese, which addressed the pathogenic and therapeutic aspects of endometriosis, published between 2012 and 2024, selected from the PubMed, Scopus and SciELO databases. After careful selection, 26 articles were chosen to compose this bibliographic review. Results: Understanding the pathogenesis of endometriosis is essential, the most recognized theory is retrograde menstruation, other theories include coelomic metaplasia and Müllerian vestiges. The inflammatory and angiogenic interaction is also significant. Management can be pharmacological or surgical, with pharmacological options ranging from anti-inflammatories, progestins to GnRH agonists. Surgical treatment, preferably laparoscopic, is beneficial for cases of infertility, but preserving ovarian function is crucial for women who wish to become pregnant. Considerations: Endometriosis presents a complex pathogenesis with several theories about its origin, including genetic influences. Management involves pharmacological and surgical options, focusing on reducing estrogen levels and controlling symptoms. Understanding these mechanisms is crucial to developing more effective therapies and improving patients' quality of life.