Defensins: antifungal lessons from eukaryotes

Detalhes bibliográficos
Autor(a) principal: Silva, Patrícia M.
Data de Publicação: 2014
Outros Autores: Gonçalves, Sónia, Santos, Nuno C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/23599
Resumo: © 2014 Silva, Gonçalves and Santos. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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spelling Defensins: antifungal lessons from eukaryotesAntimicrobial peptidesDefensinsAntifungalResistanceHost defense peptides© 2014 Silva, Gonçalves and Santos. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Over the last years, antimicrobial peptides (AMPs) have been the focus of intense research toward the finding of a viable alternative to current antifungal drugs. Defensins are one of the major families of AMPs and the most represented among all eukaryotic groups, providing an important first line of host defense against pathogenic microorganisms. Several of these cysteine-stabilized peptides present a relevant effect against fungi. Defensins are the AMPs with the broader distribution across all eukaryotic kingdoms, namely, Fungi, Plantae, and Animalia, and were recently shown to have an ancestor in a bacterial organism. As a part of the host defense, defensins act as an important vehicle of information between innate and adaptive immune system and have a role in immunomodulation. This multidimensionality represents a powerful host shield, hard for microorganisms to overcome using single approach resistance strategies. Pathogenic fungi resistance to conventional antimycotic drugs is becoming a major problem. Defensins, as other AMPs, have shown to be an effective alternative to the current antimycotic therapies, demonstrating potential as novel therapeutic agents or drug leads. In this review, we summarize the current knowledge on some eukaryotic defensins with antifungal action. An overview of the main targets in the fungal cell and the mechanism of action of these AMPs (namely, the selectivity for some fungal membrane components) are presented. Additionally, recent works on antifungal defensins structure, activity, and cytotoxicity are also reviewed.This work was partially supported by Fundação para aCiência e Tecnologia–Ministério da Educação e Ciência (FCT-MEC, Portugal) and by the European Union FP7-IRSES project MEM-PEPACROSS.Frontiers MediaRepositório da Universidade de LisboaSilva, Patrícia M.Gonçalves, SóniaSantos, Nuno C.2016-05-04T14:49:38Z20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/23599engFrontiers in Microbiology | Antimicrobials, Resistance and Chemotherapy | March 2014 | Volume5 | Article 97 | 11664-302X10.3389/fmicb.2014.00097info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:11:43Zoai:repositorio.ul.pt:10451/23599Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:40:55.137869Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Defensins: antifungal lessons from eukaryotes
title Defensins: antifungal lessons from eukaryotes
spellingShingle Defensins: antifungal lessons from eukaryotes
Silva, Patrícia M.
Antimicrobial peptides
Defensins
Antifungal
Resistance
Host defense peptides
title_short Defensins: antifungal lessons from eukaryotes
title_full Defensins: antifungal lessons from eukaryotes
title_fullStr Defensins: antifungal lessons from eukaryotes
title_full_unstemmed Defensins: antifungal lessons from eukaryotes
title_sort Defensins: antifungal lessons from eukaryotes
author Silva, Patrícia M.
author_facet Silva, Patrícia M.
Gonçalves, Sónia
Santos, Nuno C.
author_role author
author2 Gonçalves, Sónia
Santos, Nuno C.
author2_role author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Silva, Patrícia M.
Gonçalves, Sónia
Santos, Nuno C.
dc.subject.por.fl_str_mv Antimicrobial peptides
Defensins
Antifungal
Resistance
Host defense peptides
topic Antimicrobial peptides
Defensins
Antifungal
Resistance
Host defense peptides
description © 2014 Silva, Gonçalves and Santos. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-01-01T00:00:00Z
2016-05-04T14:49:38Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/23599
url http://hdl.handle.net/10451/23599
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Frontiers in Microbiology | Antimicrobials, Resistance and Chemotherapy | March 2014 | Volume5 | Article 97 | 1
1664-302X
10.3389/fmicb.2014.00097
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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