Fucoidan from Fucus vesiculosus inhibits new blood vessel formation and breast tumor growth in vivo
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/61319 |
Resumo: | Fucoidan is a marine-origin sulfated polysaccharide that can show anticancer activity, to which both pro- and anti-angiogenic responses have been reported. Due to this unpredictability, the angiogenic potential of an effective anticancer crude fucoidan (CF), at a concentration of 0.5 mg mL−1 , was evaluated. Tube formation assays demonstrated that CF, either administered while endothelial cells seeding or after their adhesion, migration and organization, inhibited or disrupted the formation of tubular-like structures, respectively. Although CF did not significantly reduced vascular endothelial growth factor (VEGF) secretion, it significantly reduced the expression of platelet-derived growth factor (PDGF), compromising the blood vessels maturation. Two chicken embryo chorioallantoic membrane (CAM) assays were performed: one without tumor (CAM I) and the other with an onplanted tumor mass (CAM II); the CF injection reduced the number of blood of vessels and significantly decreased the tumor size, respectively. In vitro and in vivo results support the effectiveness of fucoidan as a natural antitumor therapeutic agent. |
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Fucoidan from Fucus vesiculosus inhibits new blood vessel formation and breast tumor growth in vivoAngiogenesisFucoidanTumorAnticancerScience & TechnologyFucoidan is a marine-origin sulfated polysaccharide that can show anticancer activity, to which both pro- and anti-angiogenic responses have been reported. Due to this unpredictability, the angiogenic potential of an effective anticancer crude fucoidan (CF), at a concentration of 0.5 mg mL−1 , was evaluated. Tube formation assays demonstrated that CF, either administered while endothelial cells seeding or after their adhesion, migration and organization, inhibited or disrupted the formation of tubular-like structures, respectively. Although CF did not significantly reduced vascular endothelial growth factor (VEGF) secretion, it significantly reduced the expression of platelet-derived growth factor (PDGF), compromising the blood vessels maturation. Two chicken embryo chorioallantoic membrane (CAM) assays were performed: one without tumor (CAM I) and the other with an onplanted tumor mass (CAM II); the CF injection reduced the number of blood of vessels and significantly decreased the tumor size, respectively. In vitro and in vivo results support the effectiveness of fucoidan as a natural antitumor therapeutic agent.This work was developed under the scope of the Structured projects for R&D&I NORTE-01-0145-FEDER-000013, NORTE-01-0145-FEDER000021 and NORTE-01-0145-FEDER-000023, supported by the Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER), and through the Competitiveness Factors Operational Programme (COMPETE), and by National funds, through the Portuguese Foundation for Science and Technology (FCT), under the scope of the project POCI-01-0145-FEDER-007038. The authors would like also to thank NORTE 2020, for financing the PhD scholarship of C.O. “Norte-08-5369-000037” and FCT for the grant of S.G. (SFRH/BPD/117858/2016) and the Investigator grant of A.M. (IF/ 00376/2014).ElsevierUniversidade do MinhoOliveira, Ana Catarina Freitas SalazarGranja, Sara CostaNeves, N. M.Reis, R. L.Baltazar, FátimaSilva, Tiago José Quinteiros Lopes HenriquesMartins, Albino20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/61319engOliveira C., Granja S., Neves N. M., Reis R. L., Baltazar F., Silva T. H., Martins A. Fucoidan from Fucus vesiculosus inhibits new blood vessel formation and breast tumor growth in vivo, Carbohydrate Polymers, Vol. 223, doi:10.1016/j.carbpol.2019.115034, 20190144-86171879-134410.1016/j.carbpol.2019.11503431426965https://www.sciencedirect.com/science/article/pii/S0144861719307015info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T11:57:03Zoai:repositorium.sdum.uminho.pt:1822/61319Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:46:44.164062Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Fucoidan from Fucus vesiculosus inhibits new blood vessel formation and breast tumor growth in vivo |
title |
Fucoidan from Fucus vesiculosus inhibits new blood vessel formation and breast tumor growth in vivo |
spellingShingle |
Fucoidan from Fucus vesiculosus inhibits new blood vessel formation and breast tumor growth in vivo Oliveira, Ana Catarina Freitas Salazar Angiogenesis Fucoidan Tumor Anticancer Science & Technology |
title_short |
Fucoidan from Fucus vesiculosus inhibits new blood vessel formation and breast tumor growth in vivo |
title_full |
Fucoidan from Fucus vesiculosus inhibits new blood vessel formation and breast tumor growth in vivo |
title_fullStr |
Fucoidan from Fucus vesiculosus inhibits new blood vessel formation and breast tumor growth in vivo |
title_full_unstemmed |
Fucoidan from Fucus vesiculosus inhibits new blood vessel formation and breast tumor growth in vivo |
title_sort |
Fucoidan from Fucus vesiculosus inhibits new blood vessel formation and breast tumor growth in vivo |
author |
Oliveira, Ana Catarina Freitas Salazar |
author_facet |
Oliveira, Ana Catarina Freitas Salazar Granja, Sara Costa Neves, N. M. Reis, R. L. Baltazar, Fátima Silva, Tiago José Quinteiros Lopes Henriques Martins, Albino |
author_role |
author |
author2 |
Granja, Sara Costa Neves, N. M. Reis, R. L. Baltazar, Fátima Silva, Tiago José Quinteiros Lopes Henriques Martins, Albino |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Oliveira, Ana Catarina Freitas Salazar Granja, Sara Costa Neves, N. M. Reis, R. L. Baltazar, Fátima Silva, Tiago José Quinteiros Lopes Henriques Martins, Albino |
dc.subject.por.fl_str_mv |
Angiogenesis Fucoidan Tumor Anticancer Science & Technology |
topic |
Angiogenesis Fucoidan Tumor Anticancer Science & Technology |
description |
Fucoidan is a marine-origin sulfated polysaccharide that can show anticancer activity, to which both pro- and anti-angiogenic responses have been reported. Due to this unpredictability, the angiogenic potential of an effective anticancer crude fucoidan (CF), at a concentration of 0.5 mg mL−1 , was evaluated. Tube formation assays demonstrated that CF, either administered while endothelial cells seeding or after their adhesion, migration and organization, inhibited or disrupted the formation of tubular-like structures, respectively. Although CF did not significantly reduced vascular endothelial growth factor (VEGF) secretion, it significantly reduced the expression of platelet-derived growth factor (PDGF), compromising the blood vessels maturation. Two chicken embryo chorioallantoic membrane (CAM) assays were performed: one without tumor (CAM I) and the other with an onplanted tumor mass (CAM II); the CF injection reduced the number of blood of vessels and significantly decreased the tumor size, respectively. In vitro and in vivo results support the effectiveness of fucoidan as a natural antitumor therapeutic agent. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019 2019-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/61319 |
url |
http://hdl.handle.net/1822/61319 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Oliveira C., Granja S., Neves N. M., Reis R. L., Baltazar F., Silva T. H., Martins A. Fucoidan from Fucus vesiculosus inhibits new blood vessel formation and breast tumor growth in vivo, Carbohydrate Polymers, Vol. 223, doi:10.1016/j.carbpol.2019.115034, 2019 0144-8617 1879-1344 10.1016/j.carbpol.2019.115034 31426965 https://www.sciencedirect.com/science/article/pii/S0144861719307015 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132223254822912 |