A look beyond dietary (poly)phenols

Detalhes bibliográficos
Autor(a) principal: Carregosa, Diogo
Data de Publicação: 2022
Outros Autores: Pinto, Catarina, Ávila-Gálvez, María Ángeles, Bastos, Paulo, Berry, David, Santos, Cláudia Nunes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/143990
Resumo: Funding Information: European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme under grant agreement No 804229. iNOVA4Health Research Unit (LISBOA‐01‐0145‐FEDER‐007344), which is cofunded by Fundação para a Ciência e Tecnologia (FCT) / Ministério da Ciéncia e do Ensino Superior, through national funds, and by FEDER under the PT2020 Partnership Agreement, European Research Council (Starting Grant: FunKeyGut 741623). FCT (2020.04630.BD). Funding Information: This work has received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme under grant agreement No 804229. iNOVA4Health Research Unit (LISBOA‐01‐0145‐FEDER‐007344), which is cofunded by Fundação para a Ciência e Tecnologia (FCT) / Ministério da Ciência e do Ensino Superior, through national funds, and by FEDER under the PT2020 Partnership Agreement, is acknowledged. D.B. acknowledges funding by the European Research Council (Starting Grant: FunKeyGut 741623). Authors would like to acknowledge FCT for financial support of D.C. (2020.04630.BD). Publisher Copyright: © 2022 The Authors. Comprehensive Reviews in Food Science and Food Safety published by Wiley Periodicals LLC on behalf of Institute of Food Technologists.
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spelling A look beyond dietary (poly)phenolsThe low molecular weight phenolic metabolites and their concentrations in human circulationmetabolismmicrobiotapolyphenolsFood ScienceSDG 3 - Good Health and Well-beingFunding Information: European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme under grant agreement No 804229. iNOVA4Health Research Unit (LISBOA‐01‐0145‐FEDER‐007344), which is cofunded by Fundação para a Ciência e Tecnologia (FCT) / Ministério da Ciéncia e do Ensino Superior, through national funds, and by FEDER under the PT2020 Partnership Agreement, European Research Council (Starting Grant: FunKeyGut 741623). FCT (2020.04630.BD). Funding Information: This work has received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme under grant agreement No 804229. iNOVA4Health Research Unit (LISBOA‐01‐0145‐FEDER‐007344), which is cofunded by Fundação para a Ciência e Tecnologia (FCT) / Ministério da Ciência e do Ensino Superior, through national funds, and by FEDER under the PT2020 Partnership Agreement, is acknowledged. D.B. acknowledges funding by the European Research Council (Starting Grant: FunKeyGut 741623). Authors would like to acknowledge FCT for financial support of D.C. (2020.04630.BD). Publisher Copyright: © 2022 The Authors. Comprehensive Reviews in Food Science and Food Safety published by Wiley Periodicals LLC on behalf of Institute of Food Technologists.A large number of epidemiological studies have shown that consumption of fruits, vegetables, and beverages rich in (poly)phenols promote numerous health benefits from cardiovascular to neurological diseases. Evidence on (poly)phenols has been applied mainly to flavonoids, yet the role of phenolic acids has been largely overlooked. Such phenolics present in food combine with those resulting from gut microbiota catabolism of flavonoids and chlorogenic acids and those produced by endogenous pathways, resulting in large concentrations of low molecular weight phenolic metabolites in human circulation. Independently of the origin, in human intervention studies using diets rich in (poly)phenols, a total of 137 low molecular weight phenolic metabolites have been detected and quantified in human circulation with largely unknown biological function. In this review, we will pinpoint two main aspects of the low molecular weight phenolic metabolites: (i) the microbiota responsible for their generation, and (ii) the analysis (quali- and quantitative) in human circulation and their respective pharmacokinetics. In doing so, we aim to drive scientific advances regarding the ubiquitous roles of low molecular weight phenolic metabolites using physiologically relevant concentrations and under (patho)physiologically relevant conditions in humans.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)iNOVA4Health - pólo NMSRUNCarregosa, DiogoPinto, CatarinaÁvila-Gálvez, María ÁngelesBastos, PauloBerry, DavidSantos, Cláudia Nunes2022-09-23T22:18:18Z2022-092022-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/143990eng1541-4337PURE: 46516140https://doi.org/10.1111/1541-4337.13006info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:23:03Zoai:run.unl.pt:10362/143990Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:51:15.658965Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv A look beyond dietary (poly)phenols
The low molecular weight phenolic metabolites and their concentrations in human circulation
title A look beyond dietary (poly)phenols
spellingShingle A look beyond dietary (poly)phenols
Carregosa, Diogo
metabolism
microbiota
polyphenols
Food Science
SDG 3 - Good Health and Well-being
title_short A look beyond dietary (poly)phenols
title_full A look beyond dietary (poly)phenols
title_fullStr A look beyond dietary (poly)phenols
title_full_unstemmed A look beyond dietary (poly)phenols
title_sort A look beyond dietary (poly)phenols
author Carregosa, Diogo
author_facet Carregosa, Diogo
Pinto, Catarina
Ávila-Gálvez, María Ángeles
Bastos, Paulo
Berry, David
Santos, Cláudia Nunes
author_role author
author2 Pinto, Catarina
Ávila-Gálvez, María Ángeles
Bastos, Paulo
Berry, David
Santos, Cláudia Nunes
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
iNOVA4Health - pólo NMS
RUN
dc.contributor.author.fl_str_mv Carregosa, Diogo
Pinto, Catarina
Ávila-Gálvez, María Ángeles
Bastos, Paulo
Berry, David
Santos, Cláudia Nunes
dc.subject.por.fl_str_mv metabolism
microbiota
polyphenols
Food Science
SDG 3 - Good Health and Well-being
topic metabolism
microbiota
polyphenols
Food Science
SDG 3 - Good Health and Well-being
description Funding Information: European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme under grant agreement No 804229. iNOVA4Health Research Unit (LISBOA‐01‐0145‐FEDER‐007344), which is cofunded by Fundação para a Ciência e Tecnologia (FCT) / Ministério da Ciéncia e do Ensino Superior, through national funds, and by FEDER under the PT2020 Partnership Agreement, European Research Council (Starting Grant: FunKeyGut 741623). FCT (2020.04630.BD). Funding Information: This work has received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme under grant agreement No 804229. iNOVA4Health Research Unit (LISBOA‐01‐0145‐FEDER‐007344), which is cofunded by Fundação para a Ciência e Tecnologia (FCT) / Ministério da Ciência e do Ensino Superior, through national funds, and by FEDER under the PT2020 Partnership Agreement, is acknowledged. D.B. acknowledges funding by the European Research Council (Starting Grant: FunKeyGut 741623). Authors would like to acknowledge FCT for financial support of D.C. (2020.04630.BD). Publisher Copyright: © 2022 The Authors. Comprehensive Reviews in Food Science and Food Safety published by Wiley Periodicals LLC on behalf of Institute of Food Technologists.
publishDate 2022
dc.date.none.fl_str_mv 2022-09-23T22:18:18Z
2022-09
2022-09-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/143990
url http://hdl.handle.net/10362/143990
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1541-4337
PURE: 46516140
https://doi.org/10.1111/1541-4337.13006
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eu_rights_str_mv openAccess
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dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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