Circulating low density neutrophils of breast cancer patients are associated with their worse prognosis due to the impairment of T cell responses

Detalhes bibliográficos
Autor(a) principal: Saraiva, Diana P
Data de Publicação: 2021
Outros Autores: Correia, Bruna F, Salvador, Rute, de Sousa, Nídia, Jacinto, António, Braga, Sofia, Cabral, M Guadalupe
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/135676
Resumo: Funding: This work was supported by Liga Portuguesa Contra o Cancro; Fundação para a Ciência e Tecnologia (PD/BD/114023/2015, SFRH/BD/148422/2019 and 2021.08031.BD); and iNOVA4Health (UIDB/04462/2020 and DAI/2019/46).
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spelling Circulating low density neutrophils of breast cancer patients are associated with their worse prognosis due to the impairment of T cell responsesSDG 3 - Good Health and Well-beingFunding: This work was supported by Liga Portuguesa Contra o Cancro; Fundação para a Ciência e Tecnologia (PD/BD/114023/2015, SFRH/BD/148422/2019 and 2021.08031.BD); and iNOVA4Health (UIDB/04462/2020 and DAI/2019/46).Neutrophils are prominent immune components of tumors, having either anti-tumor (N1) or pro-tumor activity (N2). Circulating neutrophils, divided into high density neutrophils (HDN) and low density neutrophils (LDN), functionally mirror those N1 and N2 cells, respectively. LDN are rare in non-pathological conditions, but frequent in cancer, exhibiting a pro-tumor phenotype. These findings have been mainly demonstrated in animal models, thus proper validation in humans is still imperative. Here, we observed that LDN were increased in the blood of breast cancer (BC) patients, particularly with metastatic disease. Within the population of non-metastatic patients, LDN were more prevalent in patients with poor response to neoadjuvant chemotherapy than patients with a good response. The higher incidence of LDN in BC patients with severe disease or resistance to treatment can be explained by their pro-tumor/immunosuppressive characteristics. Moreover, the percentage of LDN in BC patients' blood was negatively correlated with activated cytotoxic T lymphocytes and positively correlated with immunosuppressive regulatory T cells. The ability of LDN to spoil anti-tumor immune responses was further demonstrated ex vivo. Hence, this study reveals the potential of LDN as a biomarker of BC response to treatment and opens new avenues for developing new immunotherapies.iNOVA4Health - pólo NMSCentro de Estudos de Doenças Crónicas (CEDOC)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNSaraiva, Diana PCorreia, Bruna FSalvador, Rutede Sousa, NídiaJacinto, AntónioBraga, SofiaCabral, M Guadalupe2022-04-01T15:38:41Z2021-11-232021-11-23T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article16application/pdfhttp://hdl.handle.net/10362/135676eng1949-2553PURE: 42844165https://doi.org/10.18632/oncotarget.28135info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:14:01Zoai:run.unl.pt:10362/135676Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:48:29.185697Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Circulating low density neutrophils of breast cancer patients are associated with their worse prognosis due to the impairment of T cell responses
title Circulating low density neutrophils of breast cancer patients are associated with their worse prognosis due to the impairment of T cell responses
spellingShingle Circulating low density neutrophils of breast cancer patients are associated with their worse prognosis due to the impairment of T cell responses
Saraiva, Diana P
SDG 3 - Good Health and Well-being
title_short Circulating low density neutrophils of breast cancer patients are associated with their worse prognosis due to the impairment of T cell responses
title_full Circulating low density neutrophils of breast cancer patients are associated with their worse prognosis due to the impairment of T cell responses
title_fullStr Circulating low density neutrophils of breast cancer patients are associated with their worse prognosis due to the impairment of T cell responses
title_full_unstemmed Circulating low density neutrophils of breast cancer patients are associated with their worse prognosis due to the impairment of T cell responses
title_sort Circulating low density neutrophils of breast cancer patients are associated with their worse prognosis due to the impairment of T cell responses
author Saraiva, Diana P
author_facet Saraiva, Diana P
Correia, Bruna F
Salvador, Rute
de Sousa, Nídia
Jacinto, António
Braga, Sofia
Cabral, M Guadalupe
author_role author
author2 Correia, Bruna F
Salvador, Rute
de Sousa, Nídia
Jacinto, António
Braga, Sofia
Cabral, M Guadalupe
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv iNOVA4Health - pólo NMS
Centro de Estudos de Doenças Crónicas (CEDOC)
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Saraiva, Diana P
Correia, Bruna F
Salvador, Rute
de Sousa, Nídia
Jacinto, António
Braga, Sofia
Cabral, M Guadalupe
dc.subject.por.fl_str_mv SDG 3 - Good Health and Well-being
topic SDG 3 - Good Health and Well-being
description Funding: This work was supported by Liga Portuguesa Contra o Cancro; Fundação para a Ciência e Tecnologia (PD/BD/114023/2015, SFRH/BD/148422/2019 and 2021.08031.BD); and iNOVA4Health (UIDB/04462/2020 and DAI/2019/46).
publishDate 2021
dc.date.none.fl_str_mv 2021-11-23
2021-11-23T00:00:00Z
2022-04-01T15:38:41Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/135676
url http://hdl.handle.net/10362/135676
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1949-2553
PURE: 42844165
https://doi.org/10.18632/oncotarget.28135
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 16
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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