Synthesis of organometallic Ruthenium(II) complexes with strong activity against several human canceer cell lines
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.21/5127 |
Resumo: | A new family of "RuCp" (Cp=eta(5)-C5H5) derivatives with bidentate N,O and N,N'-heteroaromatic ligands revealed outstanding cytotoxic properties against several human cell lines namely, A2780, A2780CisR, HT29, MCF7, MDAMB231, and PD. IC50 values were much lower than those found for cisplatin. Crystal structure of compound 4 was determined by X-ray diffraction studies. Density functional theory (DFT) calculations performed for compound 1 showed electronic flow from the ruthenium center to the coordinated bidentate ligand, in agreement with the electrochemical studies and the existence of a metal-to-ligand charge-transfer (MLCT) band evidenced by spectroscopic data. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Synthesis of organometallic Ruthenium(II) complexes with strong activity against several human canceer cell linesRuthenium(II)CyclopentadienylHeteroaromatic ligandOrganometallicEffective core potentialsCyclopentadiennyl derivative complexesMolecular calculationsHeteroaromatic ligandsAnticancer agentsInhibitionGrowthCytotoxicityChemistryElementsA new family of "RuCp" (Cp=eta(5)-C5H5) derivatives with bidentate N,O and N,N'-heteroaromatic ligands revealed outstanding cytotoxic properties against several human cell lines namely, A2780, A2780CisR, HT29, MCF7, MDAMB231, and PD. IC50 values were much lower than those found for cisplatin. Crystal structure of compound 4 was determined by X-ray diffraction studies. Density functional theory (DFT) calculations performed for compound 1 showed electronic flow from the ruthenium center to the coordinated bidentate ligand, in agreement with the electrochemical studies and the existence of a metal-to-ligand charge-transfer (MLCT) band evidenced by spectroscopic data.Elsevier Science INCRCIPLMorais, Tânia S.Silva, Tiago J. L.Marques, FernandaRobalo, Maria PaulaAvecilla, FernandoMadeira, Paulo J. AmorimMendes, Paulo J. G.Santos, IsabelGarcia, M. Helena2015-09-08T15:45:59Z2012-092012-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfhttp://hdl.handle.net/10400.21/5127eng0162-013410.1016/j.jinorgbio.2012.04.014metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T09:48:06Zoai:repositorio.ipl.pt:10400.21/5127Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:14:27.071649Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Synthesis of organometallic Ruthenium(II) complexes with strong activity against several human canceer cell lines |
title |
Synthesis of organometallic Ruthenium(II) complexes with strong activity against several human canceer cell lines |
spellingShingle |
Synthesis of organometallic Ruthenium(II) complexes with strong activity against several human canceer cell lines Morais, Tânia S. Ruthenium(II) Cyclopentadienyl Heteroaromatic ligand Organometallic Effective core potentials Cyclopentadiennyl derivative complexes Molecular calculations Heteroaromatic ligands Anticancer agents Inhibition Growth Cytotoxicity Chemistry Elements |
title_short |
Synthesis of organometallic Ruthenium(II) complexes with strong activity against several human canceer cell lines |
title_full |
Synthesis of organometallic Ruthenium(II) complexes with strong activity against several human canceer cell lines |
title_fullStr |
Synthesis of organometallic Ruthenium(II) complexes with strong activity against several human canceer cell lines |
title_full_unstemmed |
Synthesis of organometallic Ruthenium(II) complexes with strong activity against several human canceer cell lines |
title_sort |
Synthesis of organometallic Ruthenium(II) complexes with strong activity against several human canceer cell lines |
author |
Morais, Tânia S. |
author_facet |
Morais, Tânia S. Silva, Tiago J. L. Marques, Fernanda Robalo, Maria Paula Avecilla, Fernando Madeira, Paulo J. Amorim Mendes, Paulo J. G. Santos, Isabel Garcia, M. Helena |
author_role |
author |
author2 |
Silva, Tiago J. L. Marques, Fernanda Robalo, Maria Paula Avecilla, Fernando Madeira, Paulo J. Amorim Mendes, Paulo J. G. Santos, Isabel Garcia, M. Helena |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
RCIPL |
dc.contributor.author.fl_str_mv |
Morais, Tânia S. Silva, Tiago J. L. Marques, Fernanda Robalo, Maria Paula Avecilla, Fernando Madeira, Paulo J. Amorim Mendes, Paulo J. G. Santos, Isabel Garcia, M. Helena |
dc.subject.por.fl_str_mv |
Ruthenium(II) Cyclopentadienyl Heteroaromatic ligand Organometallic Effective core potentials Cyclopentadiennyl derivative complexes Molecular calculations Heteroaromatic ligands Anticancer agents Inhibition Growth Cytotoxicity Chemistry Elements |
topic |
Ruthenium(II) Cyclopentadienyl Heteroaromatic ligand Organometallic Effective core potentials Cyclopentadiennyl derivative complexes Molecular calculations Heteroaromatic ligands Anticancer agents Inhibition Growth Cytotoxicity Chemistry Elements |
description |
A new family of "RuCp" (Cp=eta(5)-C5H5) derivatives with bidentate N,O and N,N'-heteroaromatic ligands revealed outstanding cytotoxic properties against several human cell lines namely, A2780, A2780CisR, HT29, MCF7, MDAMB231, and PD. IC50 values were much lower than those found for cisplatin. Crystal structure of compound 4 was determined by X-ray diffraction studies. Density functional theory (DFT) calculations performed for compound 1 showed electronic flow from the ruthenium center to the coordinated bidentate ligand, in agreement with the electrochemical studies and the existence of a metal-to-ligand charge-transfer (MLCT) band evidenced by spectroscopic data. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-09 2012-09-01T00:00:00Z 2015-09-08T15:45:59Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.21/5127 |
url |
http://hdl.handle.net/10400.21/5127 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0162-0134 10.1016/j.jinorgbio.2012.04.014 |
dc.rights.driver.fl_str_mv |
metadata only access info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
metadata only access |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Science INC |
publisher.none.fl_str_mv |
Elsevier Science INC |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799133402432012288 |