Uterine Adenocarcinoma in pet rabbits: a review
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Tipo de documento: | Dissertação |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.26/16794 |
Resumo: | The uterine adenocarcinoma is a slow growing malignant tumour that affects 50-80% of pet rabbits over 4 years old, having age as its major risk factor. The mechanisms underlying the development of this tumour are not completely understood and some of the existing studies presented contradictory results. In fact, in rabbits there is not an adequate classification of these tumours and until now the cellular and molecular features were not fully investigated. Regarding treatment and until today, ovariohysterectomy is the only effective treatment. Without it, this neoplasia leads to the female rabbit’s death within 1 to 2 years after the appearance of symptoms and metastasis. In spite of the fact that these tumours could in other species be treated by chemotherapy, radiotherapy and hormonal therapy, in rabbits these treatments were mainly used in laboratory animals and therefore, there is no data regarding the adequate protocol. The limited studies available and the existing doubts around the development of the uterine adenocarcinoma in rabbits show that further investigation is necessary to provide other ways to make an accurate diagnosis, to establish an adequate treatment protocol and to determine the prognosis. |
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Uterine Adenocarcinoma in pet rabbits: a reviewRabbitFemaleUterine adenocarcinomaTumourCoelhaFêmeaAdenocarcinoma uterinoTumorThe uterine adenocarcinoma is a slow growing malignant tumour that affects 50-80% of pet rabbits over 4 years old, having age as its major risk factor. The mechanisms underlying the development of this tumour are not completely understood and some of the existing studies presented contradictory results. In fact, in rabbits there is not an adequate classification of these tumours and until now the cellular and molecular features were not fully investigated. Regarding treatment and until today, ovariohysterectomy is the only effective treatment. Without it, this neoplasia leads to the female rabbit’s death within 1 to 2 years after the appearance of symptoms and metastasis. In spite of the fact that these tumours could in other species be treated by chemotherapy, radiotherapy and hormonal therapy, in rabbits these treatments were mainly used in laboratory animals and therefore, there is no data regarding the adequate protocol. The limited studies available and the existing doubts around the development of the uterine adenocarcinoma in rabbits show that further investigation is necessary to provide other ways to make an accurate diagnosis, to establish an adequate treatment protocol and to determine the prognosis.O adenocarcinoma uterino é um tumor maligno de crescimento lento que afecta 50-80% dos coelhos com mais de 4 anos, sendo a idade o principal factor de risco para esta neoplasia. Os mecanismos que envolvem o desenvolvimento deste tumor não estão totalmente clarificados e alguns estudos apresentam resultados contraditórios. Actualmente, a classificação bem como a caracterização celular e molecular do adenocarcinoma uterino nesta espécie permanece pouco aprofundada. Até à data, a ovariohisterectomia é o único tratamento eficaz e, na sua ausência, o adenocarcinoma provoca a morte num período de 1 a 2 anos após o aparecimento de sintomas e metástases. Em diferentes espécies, a quimioterapia, a radioterapia e a terapia hormonal são outras opções de tratamento, no entanto nos coelhos a sua aplicação é apenas experimental e associada a animais de biotério, não existindo informação suficiente para o estabelecimento de protocolos adequados à espécie. O número limitado de estudos e as permanentes dúvidas associadas ao desenvolvimento desta patologia em coelhos evidencia a necessidade de investimento na investigação, a qual poderá revelar novas formas de diagnóstico e tratamento e, consequentemente, alterar o prognóstico.Carmo, Anália Georgina VitalVieira, Ana Luísa Nobre de Matos PereiraRepositório Comume Silva, Carolina Salgueiro Costa2016-12-14T16:53:49Z2015-06-30T00:00:00Z2015-06-30T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10400.26/16794201098512enginfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-05T13:56:47Zoai:comum.rcaap.pt:10400.26/16794Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:11:19.634737Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Uterine Adenocarcinoma in pet rabbits: a review |
title |
Uterine Adenocarcinoma in pet rabbits: a review |
spellingShingle |
Uterine Adenocarcinoma in pet rabbits: a review e Silva, Carolina Salgueiro Costa Rabbit Female Uterine adenocarcinoma Tumour Coelha Fêmea Adenocarcinoma uterino Tumor |
title_short |
Uterine Adenocarcinoma in pet rabbits: a review |
title_full |
Uterine Adenocarcinoma in pet rabbits: a review |
title_fullStr |
Uterine Adenocarcinoma in pet rabbits: a review |
title_full_unstemmed |
Uterine Adenocarcinoma in pet rabbits: a review |
title_sort |
Uterine Adenocarcinoma in pet rabbits: a review |
author |
e Silva, Carolina Salgueiro Costa |
author_facet |
e Silva, Carolina Salgueiro Costa |
author_role |
author |
dc.contributor.none.fl_str_mv |
Carmo, Anália Georgina Vital Vieira, Ana Luísa Nobre de Matos Pereira Repositório Comum |
dc.contributor.author.fl_str_mv |
e Silva, Carolina Salgueiro Costa |
dc.subject.por.fl_str_mv |
Rabbit Female Uterine adenocarcinoma Tumour Coelha Fêmea Adenocarcinoma uterino Tumor |
topic |
Rabbit Female Uterine adenocarcinoma Tumour Coelha Fêmea Adenocarcinoma uterino Tumor |
description |
The uterine adenocarcinoma is a slow growing malignant tumour that affects 50-80% of pet rabbits over 4 years old, having age as its major risk factor. The mechanisms underlying the development of this tumour are not completely understood and some of the existing studies presented contradictory results. In fact, in rabbits there is not an adequate classification of these tumours and until now the cellular and molecular features were not fully investigated. Regarding treatment and until today, ovariohysterectomy is the only effective treatment. Without it, this neoplasia leads to the female rabbit’s death within 1 to 2 years after the appearance of symptoms and metastasis. In spite of the fact that these tumours could in other species be treated by chemotherapy, radiotherapy and hormonal therapy, in rabbits these treatments were mainly used in laboratory animals and therefore, there is no data regarding the adequate protocol. The limited studies available and the existing doubts around the development of the uterine adenocarcinoma in rabbits show that further investigation is necessary to provide other ways to make an accurate diagnosis, to establish an adequate treatment protocol and to determine the prognosis. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-06-30T00:00:00Z 2015-06-30T00:00:00Z 2016-12-14T16:53:49Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.26/16794 201098512 |
url |
http://hdl.handle.net/10400.26/16794 |
identifier_str_mv |
201098512 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799129983533187072 |