Electrochemical determination of dihydrocodeine in pharmaceuticals

Detalhes bibliográficos
Autor(a) principal: Garrido, Jorge
Data de Publicação: 2003
Outros Autores: Delerue-Matos, Cristina, Borges, F., Macedo, Tice R. A., Oliveira-Brett, A. M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.22/2978
Resumo: Two analytical methods for the quality control of dihydrocodeine in commercial pharmaceutical formulations have been developed and compared with reference methods: a square wave voltammetric (SWV) method and a flow injection analysis system with electrochemical detection (FIA-EC). The electrochemical methods proposed were successfully applied to the determination of dihydrocodeine in pharmaceutical tablets and in oral solutions. These methods do not require any pretreatment of the samples, the formulation only being dissolved in a suitable electrolyte. Validation of the methods showed it to be precise, accurate and linear over the concentration range of analysis. The automatic procedure based on a flow injection analysis manifold allows a sampling rate of 115 determinations per hour.
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spelling Electrochemical determination of dihydrocodeine in pharmaceuticalsDihydrocodeineSquare wave voltammetryFlow injection analysis with electrochemical detectionFIATwo analytical methods for the quality control of dihydrocodeine in commercial pharmaceutical formulations have been developed and compared with reference methods: a square wave voltammetric (SWV) method and a flow injection analysis system with electrochemical detection (FIA-EC). The electrochemical methods proposed were successfully applied to the determination of dihydrocodeine in pharmaceutical tablets and in oral solutions. These methods do not require any pretreatment of the samples, the formulation only being dissolved in a suitable electrolyte. Validation of the methods showed it to be precise, accurate and linear over the concentration range of analysis. The automatic procedure based on a flow injection analysis manifold allows a sampling rate of 115 determinations per hour.Taylor & FrancisRepositório Científico do Instituto Politécnico do PortoGarrido, JorgeDelerue-Matos, CristinaBorges, F.Macedo, Tice R. A.Oliveira-Brett, A. M.2013-11-27T11:57:23Z20032003-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/2978eng0003-271910.1081/AL-120018246info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-13T12:42:40Zoai:recipp.ipp.pt:10400.22/2978Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:24:00.729629Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Electrochemical determination of dihydrocodeine in pharmaceuticals
title Electrochemical determination of dihydrocodeine in pharmaceuticals
spellingShingle Electrochemical determination of dihydrocodeine in pharmaceuticals
Garrido, Jorge
Dihydrocodeine
Square wave voltammetry
Flow injection analysis with electrochemical detection
FIA
title_short Electrochemical determination of dihydrocodeine in pharmaceuticals
title_full Electrochemical determination of dihydrocodeine in pharmaceuticals
title_fullStr Electrochemical determination of dihydrocodeine in pharmaceuticals
title_full_unstemmed Electrochemical determination of dihydrocodeine in pharmaceuticals
title_sort Electrochemical determination of dihydrocodeine in pharmaceuticals
author Garrido, Jorge
author_facet Garrido, Jorge
Delerue-Matos, Cristina
Borges, F.
Macedo, Tice R. A.
Oliveira-Brett, A. M.
author_role author
author2 Delerue-Matos, Cristina
Borges, F.
Macedo, Tice R. A.
Oliveira-Brett, A. M.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Politécnico do Porto
dc.contributor.author.fl_str_mv Garrido, Jorge
Delerue-Matos, Cristina
Borges, F.
Macedo, Tice R. A.
Oliveira-Brett, A. M.
dc.subject.por.fl_str_mv Dihydrocodeine
Square wave voltammetry
Flow injection analysis with electrochemical detection
FIA
topic Dihydrocodeine
Square wave voltammetry
Flow injection analysis with electrochemical detection
FIA
description Two analytical methods for the quality control of dihydrocodeine in commercial pharmaceutical formulations have been developed and compared with reference methods: a square wave voltammetric (SWV) method and a flow injection analysis system with electrochemical detection (FIA-EC). The electrochemical methods proposed were successfully applied to the determination of dihydrocodeine in pharmaceutical tablets and in oral solutions. These methods do not require any pretreatment of the samples, the formulation only being dissolved in a suitable electrolyte. Validation of the methods showed it to be precise, accurate and linear over the concentration range of analysis. The automatic procedure based on a flow injection analysis manifold allows a sampling rate of 115 determinations per hour.
publishDate 2003
dc.date.none.fl_str_mv 2003
2003-01-01T00:00:00Z
2013-11-27T11:57:23Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.22/2978
url http://hdl.handle.net/10400.22/2978
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0003-2719
10.1081/AL-120018246
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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