Gold@mesoporous silica nanocarriers for the effective delivery of antibiotics and by-passing of β-lactam resistance

Detalhes bibliográficos
Autor(a) principal: Marcelo, Gonçalo A.
Data de Publicação: 2020
Outros Autores: Duarte, Maria Paula, Oliveira, Elisabete
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/116764
Resumo: POCI-01-0145-FEDER-007265 PD/BD/142865/2018 CEECIND/00648/2017 UIDB/04077/2020 Sem PDF conforme despacho.
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spelling Gold@mesoporous silica nanocarriers for the effective delivery of antibiotics and by-passing of β-lactam resistanceAmoxicillinAntimicrobial resistanceBacteriaGold nanoparticlesMesoporous silica nanoparticlesOfloxacinEngineering(all)Environmental Science(all)Materials Science(all)Physics and Astronomy(all)Chemical Engineering(all)Earth and Planetary Sciences(all)POCI-01-0145-FEDER-007265 PD/BD/142865/2018 CEECIND/00648/2017 UIDB/04077/2020 Sem PDF conforme despacho.Current antibiotics effectiveness relies on higher doses and administration frequency, which are responsible for the growth of antimicrobial resistance (AMR). AMR is one of the major threatening issues of the century with last-line antibiotics already failing. To overcome such problems associated with bacterial infections, nanoparticles combined with antibiotics emerged as a promising strategy. In this work, nanocarriers comprising of gold–silica core–shell mesoporous nanoparticles (Au@MNs) and silica mesoporous nanoparticles (MNs) were synthesized, loaded with amoxicillin (Amox) and ofloxacin and investigated regarding its antibacterial activity towards S. aureus, methicillin-resistant S. aureus (MRSA), E. coli and P. aeruginosa. Both nanocarriers showed a beneficial role in the effective delivery of amoxicillin against MRSA and the well-known β-lactam resistant P. aeruginosa. Reductions of 10-fold (Amox@MNs) and 20-fold (Amox@Au@MNs) in the amount of antibiotic to treat P. aeruginosa; and a reduction of 20-fold (Amox@MNs) towards MRSA allied to a full reversion of resistance, strongly supports the promising potential of these nanocarriers to tackle antibiotics resistance.LAQV@REQUIMTEMEtRICS - Centro de Engenharia Mecânica e Sustentabilidade de RecursosDCTB - Departamento de Ciências e Tecnologia da Biomassa (ex-GDEH)RUNMarcelo, Gonçalo A.Duarte, Maria PaulaOliveira, Elisabete2021-05-02T22:52:20Z2020-07-082020-07-08T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/116764engPURE: 28484296https://doi.org/10.1007/s42452-020-3023-6info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:59:31Zoai:run.unl.pt:10362/116764Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:43:16.392875Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Gold@mesoporous silica nanocarriers for the effective delivery of antibiotics and by-passing of β-lactam resistance
title Gold@mesoporous silica nanocarriers for the effective delivery of antibiotics and by-passing of β-lactam resistance
spellingShingle Gold@mesoporous silica nanocarriers for the effective delivery of antibiotics and by-passing of β-lactam resistance
Marcelo, Gonçalo A.
Amoxicillin
Antimicrobial resistance
Bacteria
Gold nanoparticles
Mesoporous silica nanoparticles
Ofloxacin
Engineering(all)
Environmental Science(all)
Materials Science(all)
Physics and Astronomy(all)
Chemical Engineering(all)
Earth and Planetary Sciences(all)
title_short Gold@mesoporous silica nanocarriers for the effective delivery of antibiotics and by-passing of β-lactam resistance
title_full Gold@mesoporous silica nanocarriers for the effective delivery of antibiotics and by-passing of β-lactam resistance
title_fullStr Gold@mesoporous silica nanocarriers for the effective delivery of antibiotics and by-passing of β-lactam resistance
title_full_unstemmed Gold@mesoporous silica nanocarriers for the effective delivery of antibiotics and by-passing of β-lactam resistance
title_sort Gold@mesoporous silica nanocarriers for the effective delivery of antibiotics and by-passing of β-lactam resistance
author Marcelo, Gonçalo A.
author_facet Marcelo, Gonçalo A.
Duarte, Maria Paula
Oliveira, Elisabete
author_role author
author2 Duarte, Maria Paula
Oliveira, Elisabete
author2_role author
author
dc.contributor.none.fl_str_mv LAQV@REQUIMTE
MEtRICS - Centro de Engenharia Mecânica e Sustentabilidade de Recursos
DCTB - Departamento de Ciências e Tecnologia da Biomassa (ex-GDEH)
RUN
dc.contributor.author.fl_str_mv Marcelo, Gonçalo A.
Duarte, Maria Paula
Oliveira, Elisabete
dc.subject.por.fl_str_mv Amoxicillin
Antimicrobial resistance
Bacteria
Gold nanoparticles
Mesoporous silica nanoparticles
Ofloxacin
Engineering(all)
Environmental Science(all)
Materials Science(all)
Physics and Astronomy(all)
Chemical Engineering(all)
Earth and Planetary Sciences(all)
topic Amoxicillin
Antimicrobial resistance
Bacteria
Gold nanoparticles
Mesoporous silica nanoparticles
Ofloxacin
Engineering(all)
Environmental Science(all)
Materials Science(all)
Physics and Astronomy(all)
Chemical Engineering(all)
Earth and Planetary Sciences(all)
description POCI-01-0145-FEDER-007265 PD/BD/142865/2018 CEECIND/00648/2017 UIDB/04077/2020 Sem PDF conforme despacho.
publishDate 2020
dc.date.none.fl_str_mv 2020-07-08
2020-07-08T00:00:00Z
2021-05-02T22:52:20Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/116764
url http://hdl.handle.net/10362/116764
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv PURE: 28484296
https://doi.org/10.1007/s42452-020-3023-6
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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