Profile of cognitive impairment in late-stage Parkinson's disease

Detalhes bibliográficos
Autor(a) principal: Sousa, Catarina Severiano e
Data de Publicação: 2022
Outros Autores: Fabbri, Margherita, Godinho, Catarina, Simões, Rita Moiron, Chendo, Inês, Coelho, Miguel, Martins, Isabel Pavão, Ferreira, Joaquim J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.26/40487
Resumo: Introduction: The profile of cognitive impairment associated with the late stages of Parkinson's disease (LSPD) is rarely reported. Its characterization is necessary to better understand the cognitive changes that occur as the disease progresses and to better contribute to its management.
id RCAP_59f7492401914f9366c79c06ba64f2ba
oai_identifier_str oai:comum.rcaap.pt:10400.26/40487
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Profile of cognitive impairment in late-stage Parkinson's diseaseCognitive impairmentLate-stageParkinson’s diseaseIntroduction: The profile of cognitive impairment associated with the late stages of Parkinson's disease (LSPD) is rarely reported. Its characterization is necessary to better understand the cognitive changes that occur as the disease progresses and to better contribute to its management.Methods: In this cross-sectional study, we characterized the cognitive profile of LSPD patients using the comprehensive assessment methodology proposed by the International Parkinson and Movement Disorders Society Task Force. The association of clinical and demographic variables with dementia diagnosis was also investigated using binary logistic regression analysis.Results: Eighty-four LSPD patients were included (age 75.4 ± 6.9; disease duration 16.9 ± 7.5). Fifty-four (64.3%) were classified as demented and presented a global impairment cognitive profile. In the nondemented group (N = 30), 25 (83.3%) LSPD patients met the diagnostic criteria for mild cognitive impairment, mostly with multiple domain impairment (96.0%) and a heterogeneous profile. Memory was the most frequent and severely impaired cognitive domain in both groups. Disease disability, orientation, complex order comprehension, verbal learning, and visuoconstructive abilities were significantly associated with dementia diagnosis (p < .05).Conclusions: Cognitive impairment in multiple domains was common in LSPD patients. The most frequent and prominent deficits were in the memory domain, with a strong interference from attention impairment. Disease disability, orientation, complex order comprehension, verbal learning, and visuoconstructive abilities proved to be important determinants for dementia diagnosis.WileyRepositório ComumSousa, Catarina Severiano eFabbri, MargheritaGodinho, CatarinaSimões, Rita MoironChendo, InêsCoelho, MiguelMartins, Isabel PavãoFerreira, Joaquim J.2022-05-10T15:00:27Z2022-04-01T00:00:00Z2022-04-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.26/40487engSeveriano e Sousa, C., Fabbri, M., Godinho, C., Moiron Simões, R., Chendo, I., Coelho, M., Pavão Martins, I., & Ferreira, J. J. (2022). Profile of cognitive impairment in late-stage Parkinson's disease. Brain and Behavior, 12, e2537. https://doi.org/10.1002/brb3.25372162-327910.1002/brb3.2537info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-10-06T14:54:47Zoai:comum.rcaap.pt:10400.26/40487Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:10:26.190120Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Profile of cognitive impairment in late-stage Parkinson's disease
title Profile of cognitive impairment in late-stage Parkinson's disease
spellingShingle Profile of cognitive impairment in late-stage Parkinson's disease
Sousa, Catarina Severiano e
Cognitive impairment
Late-stage
Parkinson’s disease
title_short Profile of cognitive impairment in late-stage Parkinson's disease
title_full Profile of cognitive impairment in late-stage Parkinson's disease
title_fullStr Profile of cognitive impairment in late-stage Parkinson's disease
title_full_unstemmed Profile of cognitive impairment in late-stage Parkinson's disease
title_sort Profile of cognitive impairment in late-stage Parkinson's disease
author Sousa, Catarina Severiano e
author_facet Sousa, Catarina Severiano e
Fabbri, Margherita
Godinho, Catarina
Simões, Rita Moiron
Chendo, Inês
Coelho, Miguel
Martins, Isabel Pavão
Ferreira, Joaquim J.
author_role author
author2 Fabbri, Margherita
Godinho, Catarina
Simões, Rita Moiron
Chendo, Inês
Coelho, Miguel
Martins, Isabel Pavão
Ferreira, Joaquim J.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Comum
dc.contributor.author.fl_str_mv Sousa, Catarina Severiano e
Fabbri, Margherita
Godinho, Catarina
Simões, Rita Moiron
Chendo, Inês
Coelho, Miguel
Martins, Isabel Pavão
Ferreira, Joaquim J.
dc.subject.por.fl_str_mv Cognitive impairment
Late-stage
Parkinson’s disease
topic Cognitive impairment
Late-stage
Parkinson’s disease
description Introduction: The profile of cognitive impairment associated with the late stages of Parkinson's disease (LSPD) is rarely reported. Its characterization is necessary to better understand the cognitive changes that occur as the disease progresses and to better contribute to its management.
publishDate 2022
dc.date.none.fl_str_mv 2022-05-10T15:00:27Z
2022-04-01T00:00:00Z
2022-04-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.26/40487
url http://hdl.handle.net/10400.26/40487
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Severiano e Sousa, C., Fabbri, M., Godinho, C., Moiron Simões, R., Chendo, I., Coelho, M., Pavão Martins, I., & Ferreira, J. J. (2022). Profile of cognitive impairment in late-stage Parkinson's disease. Brain and Behavior, 12, e2537. https://doi.org/10.1002/brb3.2537
2162-3279
10.1002/brb3.2537
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799129975552475136

Registros relacionados