High frequency of psychosis in late-stage Parkinson’s disease

Detalhes bibliográficos
Autor(a) principal: Chendo, Inês
Data de Publicação: 2021
Outros Autores: Fabbri, Margherita, Godinho, Catarina, Simões, Rita Moiron, Sousa, Catarina Severiano, Coelho, Miguel, Voon, Valerie, Ferreira, Joaquim J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.26/40006
Resumo: This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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spelling High frequency of psychosis in late-stage Parkinson’s diseaseParkinson’s diseaseLate-stagePsychosisPsychiatric comorbiditiesThis is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).Background Psychosis is a frequent non-motor symptom in Parkinson’s disease (PD). Estimates of the frequency of Parkinsońs disease psychosis (PDP) vary widely. Knowledge about the frequency and phenomenology of psychosis in late-stage (LS) PD patients is limited. This study aimed to determine the frequency of psychosis in LSPD patients through clinical diagnostic interview (CDI) (gold standard), according to NINDS/NIMH diagnostic criteria for PDP. The secondary objectives were to characterize the phenomenology, to test selected instruments and assess their adequacy in comparison to CDI, and to assess the psychiatric comorbidities.Methods A cross-sectional study including LSPD patients (patients with ≥ 7 years from symptoms onset and Hoehn and Yahr scale score > 3 or a Schwab and England scale score < 50% in the ON condition) was conducted. Patients were subjected to psychiatric, neurological, and neuropsychological evaluations. Each patient was interviewed by a psychiatrist who performed a CDI.Results 92 LSPD patients were included. 55.4% experienced psychotic symptoms according to NINDS/NIMH diagnostic criteria for PDP. Hallucinations were present in 94.1% and delusions in 29.4% of the psychotic patients. Visual hallucinations were the most common (88.23%) psychotic symptom. 72.5% of LSPD patients with psychotic symptoms had at least one comorbid psychiatric diagnosis. Lower frequency of psychosis was found when the assessment was performed only through selected instruments rather than CDI.Conclusions A high frequency (55.4%) of psychotic symptoms and comorbid psychiatric (72.5%) diagnosis were found in LSPD patients. The use of CDI, in addition to structured scales may increase the sensitivity of detecting psychotic symptoms.ElsevierRepositório ComumChendo, InêsFabbri, MargheritaGodinho, CatarinaSimões, Rita MoironSousa, Catarina SeverianoCoelho, MiguelVoon, ValerieFerreira, Joaquim J.2022-04-01T12:58:59Z2021-01-01T00:00:00Z2021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.26/40006engnês Chendo, Margherita Fabbri, Catarina Godinho, Rita Moiron Simões, Catarina Severiano Sousa, Miguel Coelho, Valerie Voon, Joaquim J. Ferreira, High frequency of psychosis in late-stage Parkinsońs disease, Clinical Parkinsonism & Related Disorders, 5 (2021) 100119. https://doi.org/10.1016/j.prdoa.2021.1001192590-112510.1016/j.prdoa.2021.100119info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-10-06T14:54:44Zoai:comum.rcaap.pt:10400.26/40006Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:10:23.826864Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv High frequency of psychosis in late-stage Parkinson’s disease
title High frequency of psychosis in late-stage Parkinson’s disease
spellingShingle High frequency of psychosis in late-stage Parkinson’s disease
Chendo, Inês
Parkinson’s disease
Late-stage
Psychosis
Psychiatric comorbidities
title_short High frequency of psychosis in late-stage Parkinson’s disease
title_full High frequency of psychosis in late-stage Parkinson’s disease
title_fullStr High frequency of psychosis in late-stage Parkinson’s disease
title_full_unstemmed High frequency of psychosis in late-stage Parkinson’s disease
title_sort High frequency of psychosis in late-stage Parkinson’s disease
author Chendo, Inês
author_facet Chendo, Inês
Fabbri, Margherita
Godinho, Catarina
Simões, Rita Moiron
Sousa, Catarina Severiano
Coelho, Miguel
Voon, Valerie
Ferreira, Joaquim J.
author_role author
author2 Fabbri, Margherita
Godinho, Catarina
Simões, Rita Moiron
Sousa, Catarina Severiano
Coelho, Miguel
Voon, Valerie
Ferreira, Joaquim J.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Comum
dc.contributor.author.fl_str_mv Chendo, Inês
Fabbri, Margherita
Godinho, Catarina
Simões, Rita Moiron
Sousa, Catarina Severiano
Coelho, Miguel
Voon, Valerie
Ferreira, Joaquim J.
dc.subject.por.fl_str_mv Parkinson’s disease
Late-stage
Psychosis
Psychiatric comorbidities
topic Parkinson’s disease
Late-stage
Psychosis
Psychiatric comorbidities
description This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
publishDate 2021
dc.date.none.fl_str_mv 2021-01-01T00:00:00Z
2021-01-01T00:00:00Z
2022-04-01T12:58:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.26/40006
url http://hdl.handle.net/10400.26/40006
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv nês Chendo, Margherita Fabbri, Catarina Godinho, Rita Moiron Simões, Catarina Severiano Sousa, Miguel Coelho, Valerie Voon, Joaquim J. Ferreira, High frequency of psychosis in late-stage Parkinsońs disease, Clinical Parkinsonism & Related Disorders, 5 (2021) 100119. https://doi.org/10.1016/j.prdoa.2021.100119
2590-1125
10.1016/j.prdoa.2021.100119
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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