Poly(DL-lactic acid) scaffolds as a bone targeting platform for the co-delivery of antimicrobial agents against S. aureus-C.albicans mixed biofilms

Detalhes bibliográficos
Autor(a) principal: Zegre, Miguel
Data de Publicação: 2022
Outros Autores: Barros, J., Ribeiro, I. A., Santos, C, Caetano, Liliana Aranha, Gonçalves, L., Monteiro, F. J., Ferraz, M. P., Bettencourt, A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.21/14652
Resumo: FCT_UIDB/05608/2020. FCT_UIDP/05608/2020.
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spelling Poly(DL-lactic acid) scaffolds as a bone targeting platform for the co-delivery of antimicrobial agents against S. aureus-C.albicans mixed biofilmsBone infectionPolymicrobial biofilmsMinocyclineVoriconazoleCo-deliveryLocalized antibiotic deliveryFCT_UIDB/05608/2020FCT_UIDP/05608/2020FCT_UIDB/05608/2020. FCT_UIDP/05608/2020.New strategies for the treatment of polymicrobial bone infections are required. In this study, the co-delivery of two antimicrobials by poly(D,L-lactic acid) (PDLLA) scaffolds was investigated in a polymicrobial biofilm model. PDLLA scaffolds were prepared by solvent casting/particulate leaching methodology, incorporating minocycline and voriconazole as clinically relevant antimicrobial agents. The scaffolds presented a sponge-like appearance, suitable to support cell proliferation and drug release. Single- and dual-species biofilm models of Staphylococcus aureus and Candida albicans were developed and characterized. S. aureus presented a higher ability to form single-species biofilms, compared to C. Albicans. Minocycline and voriconazole-loaded PDLLA scaffolds showed activity against S. aureus and C. Albicans single- and dual-biofilms. Ultimately, the cytocompatibility/functional activity of PDLLA scaffolds observed in human MG-63 osteosarcoma cells unveil their potential as a next-generation co-delivery system for antimicrobial therapy in bone infections.ElsevierRCIPLZegre, MiguelBarros, J.Ribeiro, I. A.Santos, CCaetano, Liliana AranhaGonçalves, L.Monteiro, F. J.Ferraz, M. P.Bettencourt, A.2022-062022-06-01T00:00:00Z2024-05-23T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/14652engZegre M, Barros J, Ribeiro IA, Santos C, Caetano LA, Gonçalves L, et al. Poly(DL-lactic acid) scaffolds as a bone targeting platform for the co-delivery of antimicrobial agents against S. aureus-C.albicans mixed biofilms. Int J Pharm. 2022;622:121832.10.1016/j.ijpharm.2022.121832info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T10:11:08Zoai:repositorio.ipl.pt:10400.21/14652Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:22:25.507874Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Poly(DL-lactic acid) scaffolds as a bone targeting platform for the co-delivery of antimicrobial agents against S. aureus-C.albicans mixed biofilms
title Poly(DL-lactic acid) scaffolds as a bone targeting platform for the co-delivery of antimicrobial agents against S. aureus-C.albicans mixed biofilms
spellingShingle Poly(DL-lactic acid) scaffolds as a bone targeting platform for the co-delivery of antimicrobial agents against S. aureus-C.albicans mixed biofilms
Zegre, Miguel
Bone infection
Polymicrobial biofilms
Minocycline
Voriconazole
Co-delivery
Localized antibiotic delivery
FCT_UIDB/05608/2020
FCT_UIDP/05608/2020
title_short Poly(DL-lactic acid) scaffolds as a bone targeting platform for the co-delivery of antimicrobial agents against S. aureus-C.albicans mixed biofilms
title_full Poly(DL-lactic acid) scaffolds as a bone targeting platform for the co-delivery of antimicrobial agents against S. aureus-C.albicans mixed biofilms
title_fullStr Poly(DL-lactic acid) scaffolds as a bone targeting platform for the co-delivery of antimicrobial agents against S. aureus-C.albicans mixed biofilms
title_full_unstemmed Poly(DL-lactic acid) scaffolds as a bone targeting platform for the co-delivery of antimicrobial agents against S. aureus-C.albicans mixed biofilms
title_sort Poly(DL-lactic acid) scaffolds as a bone targeting platform for the co-delivery of antimicrobial agents against S. aureus-C.albicans mixed biofilms
author Zegre, Miguel
author_facet Zegre, Miguel
Barros, J.
Ribeiro, I. A.
Santos, C
Caetano, Liliana Aranha
Gonçalves, L.
Monteiro, F. J.
Ferraz, M. P.
Bettencourt, A.
author_role author
author2 Barros, J.
Ribeiro, I. A.
Santos, C
Caetano, Liliana Aranha
Gonçalves, L.
Monteiro, F. J.
Ferraz, M. P.
Bettencourt, A.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv RCIPL
dc.contributor.author.fl_str_mv Zegre, Miguel
Barros, J.
Ribeiro, I. A.
Santos, C
Caetano, Liliana Aranha
Gonçalves, L.
Monteiro, F. J.
Ferraz, M. P.
Bettencourt, A.
dc.subject.por.fl_str_mv Bone infection
Polymicrobial biofilms
Minocycline
Voriconazole
Co-delivery
Localized antibiotic delivery
FCT_UIDB/05608/2020
FCT_UIDP/05608/2020
topic Bone infection
Polymicrobial biofilms
Minocycline
Voriconazole
Co-delivery
Localized antibiotic delivery
FCT_UIDB/05608/2020
FCT_UIDP/05608/2020
description FCT_UIDB/05608/2020. FCT_UIDP/05608/2020.
publishDate 2022
dc.date.none.fl_str_mv 2022-06
2022-06-01T00:00:00Z
2024-05-23T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.21/14652
url http://hdl.handle.net/10400.21/14652
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Zegre M, Barros J, Ribeiro IA, Santos C, Caetano LA, Gonçalves L, et al. Poly(DL-lactic acid) scaffolds as a bone targeting platform for the co-delivery of antimicrobial agents against S. aureus-C.albicans mixed biofilms. Int J Pharm. 2022;622:121832.
10.1016/j.ijpharm.2022.121832
dc.rights.driver.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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