Research progress on biodegradable polymeric platforms for targeting antibiotics to the bone

Detalhes bibliográficos
Autor(a) principal: Zegre, Miguel
Data de Publicação: 2023
Outros Autores: Poljańska, E., Caetano, Liliana Aranha, Gonçalves, L., Bettencourt, A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.21/16637
Resumo: FCT_UIDB/05608/2020. FCT_UIDP/05608/2020.
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spelling Research progress on biodegradable polymeric platforms for targeting antibiotics to the bonePolymersBiodegradableBone infectionAntibioticsDrug delivery systemsFCT_UIDP/05608/2020FCT_UIDP/05608/2020FCT_UIDB/05608/2020. FCT_UIDP/05608/2020.The treatment of bone infections still involves systemic or local antibiotic therapy in high doses for prolonged periods. Current research focuses on the application of different drug delivery systems to the bone, aiming at a targeted local administration that will decrease the number of drugs used and their toxicity, compared to the systemic route. The gold standard in clinical practice is currently poly(methyl methacrylate) (PMMA) cement. The main drawback of PMMA, however, is that it is non-biodegradable, requiring a second follow-up surgery to remove the implant. Biodegradable delivery systems, on the other hand, are easily resorbable within the organism, and less invasive alternative with better patient compliance. Among biodegradable materials, natural and synthetic polymers are being studied as local drug delivery systems due to their excellent biocompatibility, sustained effect, and antibiotic release with high penetrability to infected bone and soft tissue. In this review, we focus on biodegradable polymeric platforms, such as micro- and nanoparticles, scaffolds, and hydrogels, as well as multi-delivery systems for targeting antibiotics to the bone. Additionally, we discuss the reported drug release profiles that provide important information about the systems’ functionality.RCIPLZegre, MiguelPoljańska, E.Caetano, Liliana AranhaGonçalves, L.Bettencourt, A.2023-122023-12-01T00:00:00Z2025-12-07T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/16637engZegre M, Poljańska E, Caetano LA, Gonçalves L, Bettencourt A. Research progress on biodegradable polymeric platforms for targeting antibiotics to the bone. Int J Pharm. 2023;648:123584.10.1016/j.ijpharm.2023.123584info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-13T02:18:23Zoai:repositorio.ipl.pt:10400.21/16637Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:42:23.829350Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Research progress on biodegradable polymeric platforms for targeting antibiotics to the bone
title Research progress on biodegradable polymeric platforms for targeting antibiotics to the bone
spellingShingle Research progress on biodegradable polymeric platforms for targeting antibiotics to the bone
Zegre, Miguel
Polymers
Biodegradable
Bone infection
Antibiotics
Drug delivery systems
FCT_UIDP/05608/2020
FCT_UIDP/05608/2020
title_short Research progress on biodegradable polymeric platforms for targeting antibiotics to the bone
title_full Research progress on biodegradable polymeric platforms for targeting antibiotics to the bone
title_fullStr Research progress on biodegradable polymeric platforms for targeting antibiotics to the bone
title_full_unstemmed Research progress on biodegradable polymeric platforms for targeting antibiotics to the bone
title_sort Research progress on biodegradable polymeric platforms for targeting antibiotics to the bone
author Zegre, Miguel
author_facet Zegre, Miguel
Poljańska, E.
Caetano, Liliana Aranha
Gonçalves, L.
Bettencourt, A.
author_role author
author2 Poljańska, E.
Caetano, Liliana Aranha
Gonçalves, L.
Bettencourt, A.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv RCIPL
dc.contributor.author.fl_str_mv Zegre, Miguel
Poljańska, E.
Caetano, Liliana Aranha
Gonçalves, L.
Bettencourt, A.
dc.subject.por.fl_str_mv Polymers
Biodegradable
Bone infection
Antibiotics
Drug delivery systems
FCT_UIDP/05608/2020
FCT_UIDP/05608/2020
topic Polymers
Biodegradable
Bone infection
Antibiotics
Drug delivery systems
FCT_UIDP/05608/2020
FCT_UIDP/05608/2020
description FCT_UIDB/05608/2020. FCT_UIDP/05608/2020.
publishDate 2023
dc.date.none.fl_str_mv 2023-12
2023-12-01T00:00:00Z
2025-12-07T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.21/16637
url http://hdl.handle.net/10400.21/16637
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Zegre M, Poljańska E, Caetano LA, Gonçalves L, Bettencourt A. Research progress on biodegradable polymeric platforms for targeting antibiotics to the bone. Int J Pharm. 2023;648:123584.
10.1016/j.ijpharm.2023.123584
dc.rights.driver.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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