In vivo, ex vivo and in vitro assessment of buccal permeation of drugs from delivery systems
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.14/29107 |
Resumo: | Introduction: Buccal mucosa has been described as an attractive site for local and systemic drug delivery, owing its accessibility, safety, and excellent blood supply. The absorption of drugs through buccal mucosa has been assessed by in vivo, ex vivo and in vitro permeability studies, using animal and cell-based models with close resemblance to the human buccal mucosa. Areas covered: This paper focuses on the current in vivo, ex vivo and in vitro permeability studies to analyze the absorption of compounds of interest through buccal mucosa, as well as their advantages and limitations in the preclinical studies of the drugs absorption profiles. The techniques for preparation and preservation of the animal buccal tissue are also discussed to evaluate their interference in the integrity and permeability of the tissues. Expert opinion: Overall, the permeability studies have been useful to evaluate the drugs absorption and to clarify the mechanism of transport of drugs across human buccal mucosa, as well as to explain the enhancement of permeability provided by certain dosage forms. Currently, several researchers have demonstrated particular interest in ex vivo permeability studies, due to their effectiveness in the evaluation of drug absorption and low costs in the acquisition of buccal mucosa samples. |
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In vivo, ex vivo and in vitro assessment of buccal permeation of drugs from delivery systemsOral cavityDrug delivery systemsPermeability studiesAnimal modelsEx vivo studiesIntroduction: Buccal mucosa has been described as an attractive site for local and systemic drug delivery, owing its accessibility, safety, and excellent blood supply. The absorption of drugs through buccal mucosa has been assessed by in vivo, ex vivo and in vitro permeability studies, using animal and cell-based models with close resemblance to the human buccal mucosa. Areas covered: This paper focuses on the current in vivo, ex vivo and in vitro permeability studies to analyze the absorption of compounds of interest through buccal mucosa, as well as their advantages and limitations in the preclinical studies of the drugs absorption profiles. The techniques for preparation and preservation of the animal buccal tissue are also discussed to evaluate their interference in the integrity and permeability of the tissues. Expert opinion: Overall, the permeability studies have been useful to evaluate the drugs absorption and to clarify the mechanism of transport of drugs across human buccal mucosa, as well as to explain the enhancement of permeability provided by certain dosage forms. Currently, several researchers have demonstrated particular interest in ex vivo permeability studies, due to their effectiveness in the evaluation of drug absorption and low costs in the acquisition of buccal mucosa samples.Taylor & FrancisVeritati - Repositório Institucional da Universidade Católica PortuguesaPinto, SoraiaPintado, Manuela E.Sarmento, Bruno2021-01-02T01:30:12Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.14/29107engPinto, S., Pintado, M. E., Sarmento, B. (2019). In vivo, ex vivo and in vitro assessment of buccal permeation of drugs from delivery systems. Expert Opinion on Drug Delivery1742-524710.1080/17425247.2020.16999131744-759331786958WOS:000500139600001info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-12T17:34:34Zoai:repositorio.ucp.pt:10400.14/29107Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:23:18.938650Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
In vivo, ex vivo and in vitro assessment of buccal permeation of drugs from delivery systems |
title |
In vivo, ex vivo and in vitro assessment of buccal permeation of drugs from delivery systems |
spellingShingle |
In vivo, ex vivo and in vitro assessment of buccal permeation of drugs from delivery systems Pinto, Soraia Oral cavity Drug delivery systems Permeability studies Animal models Ex vivo studies |
title_short |
In vivo, ex vivo and in vitro assessment of buccal permeation of drugs from delivery systems |
title_full |
In vivo, ex vivo and in vitro assessment of buccal permeation of drugs from delivery systems |
title_fullStr |
In vivo, ex vivo and in vitro assessment of buccal permeation of drugs from delivery systems |
title_full_unstemmed |
In vivo, ex vivo and in vitro assessment of buccal permeation of drugs from delivery systems |
title_sort |
In vivo, ex vivo and in vitro assessment of buccal permeation of drugs from delivery systems |
author |
Pinto, Soraia |
author_facet |
Pinto, Soraia Pintado, Manuela E. Sarmento, Bruno |
author_role |
author |
author2 |
Pintado, Manuela E. Sarmento, Bruno |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Veritati - Repositório Institucional da Universidade Católica Portuguesa |
dc.contributor.author.fl_str_mv |
Pinto, Soraia Pintado, Manuela E. Sarmento, Bruno |
dc.subject.por.fl_str_mv |
Oral cavity Drug delivery systems Permeability studies Animal models Ex vivo studies |
topic |
Oral cavity Drug delivery systems Permeability studies Animal models Ex vivo studies |
description |
Introduction: Buccal mucosa has been described as an attractive site for local and systemic drug delivery, owing its accessibility, safety, and excellent blood supply. The absorption of drugs through buccal mucosa has been assessed by in vivo, ex vivo and in vitro permeability studies, using animal and cell-based models with close resemblance to the human buccal mucosa. Areas covered: This paper focuses on the current in vivo, ex vivo and in vitro permeability studies to analyze the absorption of compounds of interest through buccal mucosa, as well as their advantages and limitations in the preclinical studies of the drugs absorption profiles. The techniques for preparation and preservation of the animal buccal tissue are also discussed to evaluate their interference in the integrity and permeability of the tissues. Expert opinion: Overall, the permeability studies have been useful to evaluate the drugs absorption and to clarify the mechanism of transport of drugs across human buccal mucosa, as well as to explain the enhancement of permeability provided by certain dosage forms. Currently, several researchers have demonstrated particular interest in ex vivo permeability studies, due to their effectiveness in the evaluation of drug absorption and low costs in the acquisition of buccal mucosa samples. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019 2019-01-01T00:00:00Z 2021-01-02T01:30:12Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.14/29107 |
url |
http://hdl.handle.net/10400.14/29107 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Pinto, S., Pintado, M. E., Sarmento, B. (2019). In vivo, ex vivo and in vitro assessment of buccal permeation of drugs from delivery systems. Expert Opinion on Drug Delivery 1742-5247 10.1080/17425247.2020.1699913 1744-7593 31786958 WOS:000500139600001 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Taylor & Francis |
publisher.none.fl_str_mv |
Taylor & Francis |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799131940313366528 |