Erythrocytic enzymatic systems and their antioxidative potential in pregnant women undergoing labor induction with intracervical PGE2.

Detalhes bibliográficos
Autor(a) principal: Cruz, Artur Silva
Data de Publicação: 1995
Outros Autores: Neves, Joaquim Silva, Cano, José, Arteaga, Maria Paula, Siqueira, Cíntia, Franco, Maria Helena, Bicho, Manuel Pires
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2728
Resumo: Our purpose is to correlate, the apgar score of the new-borns from induction of labour (IL) with Prostaglandin E2 (PGE2) endocervical gel, and the oxidative environment of the pregnant woman during labour, studying biochemical markers of the erythrocytes. PGE2 is responsible for the regulation of the vascular response in pregnancy, namely for the vasoconstriction caused by Angitensin II. The production of Prostaglandins in vivo depends on mechanisms related to free radicals of oxygen (FRO). The production of FRO is enhanced in normal pregnancy. We have studied two erythrocytic enzymes and plasmatic concentration of PGE2 before and after the IL. Those enzymes are oxireductases-the transmembrane reductase (RTM) and the metahemoglobin reductase (MHR). Their function is to prevent the effects of the FRO on cellular biomolecules namely the endothelium and the red blood cells. This prevention of oxidative stress can facilitate the deformability of the erythrocytes, so these cells can easily transpose the small vessels and bind the oxygen to the tissues. The activity of those enzymes can be modulated by PGE2 used in the IL. We have not found significant variations on the activity of RTM after IL. The activity of MHR was enhanced with statistical significance, 30 minutes after the induction. This enhancement of activity can be a mechanism to prevent the oxidative stress of the induction of labour.
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spelling Erythrocytic enzymatic systems and their antioxidative potential in pregnant women undergoing labor induction with intracervical PGE2.Sistemas enzimáticos eritrocitários e seu potencial antioxidante nas grávidas submetidas a indução do trabalho de parto com PGE2 intracervical.Our purpose is to correlate, the apgar score of the new-borns from induction of labour (IL) with Prostaglandin E2 (PGE2) endocervical gel, and the oxidative environment of the pregnant woman during labour, studying biochemical markers of the erythrocytes. PGE2 is responsible for the regulation of the vascular response in pregnancy, namely for the vasoconstriction caused by Angitensin II. The production of Prostaglandins in vivo depends on mechanisms related to free radicals of oxygen (FRO). The production of FRO is enhanced in normal pregnancy. We have studied two erythrocytic enzymes and plasmatic concentration of PGE2 before and after the IL. Those enzymes are oxireductases-the transmembrane reductase (RTM) and the metahemoglobin reductase (MHR). Their function is to prevent the effects of the FRO on cellular biomolecules namely the endothelium and the red blood cells. This prevention of oxidative stress can facilitate the deformability of the erythrocytes, so these cells can easily transpose the small vessels and bind the oxygen to the tissues. The activity of those enzymes can be modulated by PGE2 used in the IL. We have not found significant variations on the activity of RTM after IL. The activity of MHR was enhanced with statistical significance, 30 minutes after the induction. This enhancement of activity can be a mechanism to prevent the oxidative stress of the induction of labour.Our purpose is to correlate, the apgar score of the new-borns from induction of labour (IL) with Prostaglandin E2 (PGE2) endocervical gel, and the oxidative environment of the pregnant woman during labour, studying biochemical markers of the erythrocytes. PGE2 is responsible for the regulation of the vascular response in pregnancy, namely for the vasoconstriction caused by Angitensin II. The production of Prostaglandins in vivo depends on mechanisms related to free radicals of oxygen (FRO). The production of FRO is enhanced in normal pregnancy. We have studied two erythrocytic enzymes and plasmatic concentration of PGE2 before and after the IL. Those enzymes are oxireductases-the transmembrane reductase (RTM) and the metahemoglobin reductase (MHR). Their function is to prevent the effects of the FRO on cellular biomolecules namely the endothelium and the red blood cells. This prevention of oxidative stress can facilitate the deformability of the erythrocytes, so these cells can easily transpose the small vessels and bind the oxygen to the tissues. The activity of those enzymes can be modulated by PGE2 used in the IL. We have not found significant variations on the activity of RTM after IL. The activity of MHR was enhanced with statistical significance, 30 minutes after the induction. This enhancement of activity can be a mechanism to prevent the oxidative stress of the induction of labour.Ordem dos Médicos1995-08-30info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2728oai:ojs.www.actamedicaportuguesa.com:article/2728Acta Médica Portuguesa; Vol. 8 No. 7-8 (1995): Julho-Agosto; 415-8Acta Médica Portuguesa; Vol. 8 N.º 7-8 (1995): Julho-Agosto; 415-81646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2728https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2728/2118Direitos de Autor (c) 1995 Acta Médica Portuguesainfo:eu-repo/semantics/openAccessCruz, Artur SilvaNeves, Joaquim SilvaCano, JoséArteaga, Maria PaulaSiqueira, CíntiaFranco, Maria HelenaBicho, Manuel Pires2022-12-20T11:01:04Zoai:ojs.www.actamedicaportuguesa.com:article/2728Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:17:55.906010Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Erythrocytic enzymatic systems and their antioxidative potential in pregnant women undergoing labor induction with intracervical PGE2.
Sistemas enzimáticos eritrocitários e seu potencial antioxidante nas grávidas submetidas a indução do trabalho de parto com PGE2 intracervical.
title Erythrocytic enzymatic systems and their antioxidative potential in pregnant women undergoing labor induction with intracervical PGE2.
spellingShingle Erythrocytic enzymatic systems and their antioxidative potential in pregnant women undergoing labor induction with intracervical PGE2.
Cruz, Artur Silva
title_short Erythrocytic enzymatic systems and their antioxidative potential in pregnant women undergoing labor induction with intracervical PGE2.
title_full Erythrocytic enzymatic systems and their antioxidative potential in pregnant women undergoing labor induction with intracervical PGE2.
title_fullStr Erythrocytic enzymatic systems and their antioxidative potential in pregnant women undergoing labor induction with intracervical PGE2.
title_full_unstemmed Erythrocytic enzymatic systems and their antioxidative potential in pregnant women undergoing labor induction with intracervical PGE2.
title_sort Erythrocytic enzymatic systems and their antioxidative potential in pregnant women undergoing labor induction with intracervical PGE2.
author Cruz, Artur Silva
author_facet Cruz, Artur Silva
Neves, Joaquim Silva
Cano, José
Arteaga, Maria Paula
Siqueira, Cíntia
Franco, Maria Helena
Bicho, Manuel Pires
author_role author
author2 Neves, Joaquim Silva
Cano, José
Arteaga, Maria Paula
Siqueira, Cíntia
Franco, Maria Helena
Bicho, Manuel Pires
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cruz, Artur Silva
Neves, Joaquim Silva
Cano, José
Arteaga, Maria Paula
Siqueira, Cíntia
Franco, Maria Helena
Bicho, Manuel Pires
description Our purpose is to correlate, the apgar score of the new-borns from induction of labour (IL) with Prostaglandin E2 (PGE2) endocervical gel, and the oxidative environment of the pregnant woman during labour, studying biochemical markers of the erythrocytes. PGE2 is responsible for the regulation of the vascular response in pregnancy, namely for the vasoconstriction caused by Angitensin II. The production of Prostaglandins in vivo depends on mechanisms related to free radicals of oxygen (FRO). The production of FRO is enhanced in normal pregnancy. We have studied two erythrocytic enzymes and plasmatic concentration of PGE2 before and after the IL. Those enzymes are oxireductases-the transmembrane reductase (RTM) and the metahemoglobin reductase (MHR). Their function is to prevent the effects of the FRO on cellular biomolecules namely the endothelium and the red blood cells. This prevention of oxidative stress can facilitate the deformability of the erythrocytes, so these cells can easily transpose the small vessels and bind the oxygen to the tissues. The activity of those enzymes can be modulated by PGE2 used in the IL. We have not found significant variations on the activity of RTM after IL. The activity of MHR was enhanced with statistical significance, 30 minutes after the induction. This enhancement of activity can be a mechanism to prevent the oxidative stress of the induction of labour.
publishDate 1995
dc.date.none.fl_str_mv 1995-08-30
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2728/2118
dc.rights.driver.fl_str_mv Direitos de Autor (c) 1995 Acta Médica Portuguesa
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Direitos de Autor (c) 1995 Acta Médica Portuguesa
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dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Ordem dos Médicos
publisher.none.fl_str_mv Ordem dos Médicos
dc.source.none.fl_str_mv Acta Médica Portuguesa; Vol. 8 No. 7-8 (1995): Julho-Agosto; 415-8
Acta Médica Portuguesa; Vol. 8 N.º 7-8 (1995): Julho-Agosto; 415-8
1646-0758
0870-399X
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