Erythrocytic enzymatic systems and their antioxidative potential in pregnant women undergoing labor induction with intracervical PGE2.
Autor(a) principal: | |
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Data de Publicação: | 1995 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2728 |
Resumo: | Our purpose is to correlate, the apgar score of the new-borns from induction of labour (IL) with Prostaglandin E2 (PGE2) endocervical gel, and the oxidative environment of the pregnant woman during labour, studying biochemical markers of the erythrocytes. PGE2 is responsible for the regulation of the vascular response in pregnancy, namely for the vasoconstriction caused by Angitensin II. The production of Prostaglandins in vivo depends on mechanisms related to free radicals of oxygen (FRO). The production of FRO is enhanced in normal pregnancy. We have studied two erythrocytic enzymes and plasmatic concentration of PGE2 before and after the IL. Those enzymes are oxireductases-the transmembrane reductase (RTM) and the metahemoglobin reductase (MHR). Their function is to prevent the effects of the FRO on cellular biomolecules namely the endothelium and the red blood cells. This prevention of oxidative stress can facilitate the deformability of the erythrocytes, so these cells can easily transpose the small vessels and bind the oxygen to the tissues. The activity of those enzymes can be modulated by PGE2 used in the IL. We have not found significant variations on the activity of RTM after IL. The activity of MHR was enhanced with statistical significance, 30 minutes after the induction. This enhancement of activity can be a mechanism to prevent the oxidative stress of the induction of labour. |
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Erythrocytic enzymatic systems and their antioxidative potential in pregnant women undergoing labor induction with intracervical PGE2.Sistemas enzimáticos eritrocitários e seu potencial antioxidante nas grávidas submetidas a indução do trabalho de parto com PGE2 intracervical.Our purpose is to correlate, the apgar score of the new-borns from induction of labour (IL) with Prostaglandin E2 (PGE2) endocervical gel, and the oxidative environment of the pregnant woman during labour, studying biochemical markers of the erythrocytes. PGE2 is responsible for the regulation of the vascular response in pregnancy, namely for the vasoconstriction caused by Angitensin II. The production of Prostaglandins in vivo depends on mechanisms related to free radicals of oxygen (FRO). The production of FRO is enhanced in normal pregnancy. We have studied two erythrocytic enzymes and plasmatic concentration of PGE2 before and after the IL. Those enzymes are oxireductases-the transmembrane reductase (RTM) and the metahemoglobin reductase (MHR). Their function is to prevent the effects of the FRO on cellular biomolecules namely the endothelium and the red blood cells. This prevention of oxidative stress can facilitate the deformability of the erythrocytes, so these cells can easily transpose the small vessels and bind the oxygen to the tissues. The activity of those enzymes can be modulated by PGE2 used in the IL. We have not found significant variations on the activity of RTM after IL. The activity of MHR was enhanced with statistical significance, 30 minutes after the induction. This enhancement of activity can be a mechanism to prevent the oxidative stress of the induction of labour.Our purpose is to correlate, the apgar score of the new-borns from induction of labour (IL) with Prostaglandin E2 (PGE2) endocervical gel, and the oxidative environment of the pregnant woman during labour, studying biochemical markers of the erythrocytes. PGE2 is responsible for the regulation of the vascular response in pregnancy, namely for the vasoconstriction caused by Angitensin II. The production of Prostaglandins in vivo depends on mechanisms related to free radicals of oxygen (FRO). The production of FRO is enhanced in normal pregnancy. We have studied two erythrocytic enzymes and plasmatic concentration of PGE2 before and after the IL. Those enzymes are oxireductases-the transmembrane reductase (RTM) and the metahemoglobin reductase (MHR). Their function is to prevent the effects of the FRO on cellular biomolecules namely the endothelium and the red blood cells. This prevention of oxidative stress can facilitate the deformability of the erythrocytes, so these cells can easily transpose the small vessels and bind the oxygen to the tissues. The activity of those enzymes can be modulated by PGE2 used in the IL. We have not found significant variations on the activity of RTM after IL. The activity of MHR was enhanced with statistical significance, 30 minutes after the induction. This enhancement of activity can be a mechanism to prevent the oxidative stress of the induction of labour.Ordem dos Médicos1995-08-30info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2728oai:ojs.www.actamedicaportuguesa.com:article/2728Acta Médica Portuguesa; Vol. 8 No. 7-8 (1995): Julho-Agosto; 415-8Acta Médica Portuguesa; Vol. 8 N.º 7-8 (1995): Julho-Agosto; 415-81646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2728https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2728/2118Direitos de Autor (c) 1995 Acta Médica Portuguesainfo:eu-repo/semantics/openAccessCruz, Artur SilvaNeves, Joaquim SilvaCano, JoséArteaga, Maria PaulaSiqueira, CíntiaFranco, Maria HelenaBicho, Manuel Pires2022-12-20T11:01:04Zoai:ojs.www.actamedicaportuguesa.com:article/2728Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:17:55.906010Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Erythrocytic enzymatic systems and their antioxidative potential in pregnant women undergoing labor induction with intracervical PGE2. Sistemas enzimáticos eritrocitários e seu potencial antioxidante nas grávidas submetidas a indução do trabalho de parto com PGE2 intracervical. |
title |
Erythrocytic enzymatic systems and their antioxidative potential in pregnant women undergoing labor induction with intracervical PGE2. |
spellingShingle |
Erythrocytic enzymatic systems and their antioxidative potential in pregnant women undergoing labor induction with intracervical PGE2. Cruz, Artur Silva |
title_short |
Erythrocytic enzymatic systems and their antioxidative potential in pregnant women undergoing labor induction with intracervical PGE2. |
title_full |
Erythrocytic enzymatic systems and their antioxidative potential in pregnant women undergoing labor induction with intracervical PGE2. |
title_fullStr |
Erythrocytic enzymatic systems and their antioxidative potential in pregnant women undergoing labor induction with intracervical PGE2. |
title_full_unstemmed |
Erythrocytic enzymatic systems and their antioxidative potential in pregnant women undergoing labor induction with intracervical PGE2. |
title_sort |
Erythrocytic enzymatic systems and their antioxidative potential in pregnant women undergoing labor induction with intracervical PGE2. |
author |
Cruz, Artur Silva |
author_facet |
Cruz, Artur Silva Neves, Joaquim Silva Cano, José Arteaga, Maria Paula Siqueira, Cíntia Franco, Maria Helena Bicho, Manuel Pires |
author_role |
author |
author2 |
Neves, Joaquim Silva Cano, José Arteaga, Maria Paula Siqueira, Cíntia Franco, Maria Helena Bicho, Manuel Pires |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Cruz, Artur Silva Neves, Joaquim Silva Cano, José Arteaga, Maria Paula Siqueira, Cíntia Franco, Maria Helena Bicho, Manuel Pires |
description |
Our purpose is to correlate, the apgar score of the new-borns from induction of labour (IL) with Prostaglandin E2 (PGE2) endocervical gel, and the oxidative environment of the pregnant woman during labour, studying biochemical markers of the erythrocytes. PGE2 is responsible for the regulation of the vascular response in pregnancy, namely for the vasoconstriction caused by Angitensin II. The production of Prostaglandins in vivo depends on mechanisms related to free radicals of oxygen (FRO). The production of FRO is enhanced in normal pregnancy. We have studied two erythrocytic enzymes and plasmatic concentration of PGE2 before and after the IL. Those enzymes are oxireductases-the transmembrane reductase (RTM) and the metahemoglobin reductase (MHR). Their function is to prevent the effects of the FRO on cellular biomolecules namely the endothelium and the red blood cells. This prevention of oxidative stress can facilitate the deformability of the erythrocytes, so these cells can easily transpose the small vessels and bind the oxygen to the tissues. The activity of those enzymes can be modulated by PGE2 used in the IL. We have not found significant variations on the activity of RTM after IL. The activity of MHR was enhanced with statistical significance, 30 minutes after the induction. This enhancement of activity can be a mechanism to prevent the oxidative stress of the induction of labour. |
publishDate |
1995 |
dc.date.none.fl_str_mv |
1995-08-30 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2728 oai:ojs.www.actamedicaportuguesa.com:article/2728 |
url |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2728 |
identifier_str_mv |
oai:ojs.www.actamedicaportuguesa.com:article/2728 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2728 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2728/2118 |
dc.rights.driver.fl_str_mv |
Direitos de Autor (c) 1995 Acta Médica Portuguesa info:eu-repo/semantics/openAccess |
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Direitos de Autor (c) 1995 Acta Médica Portuguesa |
eu_rights_str_mv |
openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Ordem dos Médicos |
publisher.none.fl_str_mv |
Ordem dos Médicos |
dc.source.none.fl_str_mv |
Acta Médica Portuguesa; Vol. 8 No. 7-8 (1995): Julho-Agosto; 415-8 Acta Médica Portuguesa; Vol. 8 N.º 7-8 (1995): Julho-Agosto; 415-8 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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