Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2014-2015
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.18/4549 |
Resumo: | The World Health Organization (WHO) Collaborating Centres for Reference and Research on Influenza (WHO CCs) tested 13,312 viruses collected by WHO recognized National Influenza Centres between May 2014 and May 2015 to determine 50% inhibitory concentration (IC50) data for neuraminidase inhibitors (NAIs) oseltamivir, zanamivir, peramivir and laninamivir. Ninety-four per cent of the viruses tested by the WHO CCs were from three WHO regions: Western Pacific, the Americas and Europe. Approximately 0.5% (n = 68) of viruses showed either highly reduced inhibition (HRI) or reduced inhibition (RI) (n = 56) against at least one of the four NAIs. Of the twelve viruses with HRI, six were A(H1N1)pdm09 viruses, three were A(H3N2) viruses and three were B/Yamagata-lineage viruses. The overall frequency of viruses with RI or HRI by the NAIs was lower than that observed in 2013-14 (1.9%), but similar to the 2012-13 period (0.6%). Based on the current analysis, the NAIs remain an appropriate choice for the treatment and prophylaxis of influenza virus infections. |
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Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2014-2015Antiviral ResistanceGlobal AnalysisInfluenza VirusNeuraminidase InhibitorsOseltamivirReduced SusceptibilityResistência aos AntimicrobianosThe World Health Organization (WHO) Collaborating Centres for Reference and Research on Influenza (WHO CCs) tested 13,312 viruses collected by WHO recognized National Influenza Centres between May 2014 and May 2015 to determine 50% inhibitory concentration (IC50) data for neuraminidase inhibitors (NAIs) oseltamivir, zanamivir, peramivir and laninamivir. Ninety-four per cent of the viruses tested by the WHO CCs were from three WHO regions: Western Pacific, the Americas and Europe. Approximately 0.5% (n = 68) of viruses showed either highly reduced inhibition (HRI) or reduced inhibition (RI) (n = 56) against at least one of the four NAIs. Of the twelve viruses with HRI, six were A(H1N1)pdm09 viruses, three were A(H3N2) viruses and three were B/Yamagata-lineage viruses. The overall frequency of viruses with RI or HRI by the NAIs was lower than that observed in 2013-14 (1.9%), but similar to the 2012-13 period (0.6%). Based on the current analysis, the NAIs remain an appropriate choice for the treatment and prophylaxis of influenza virus infections.Elsevier Masson/ International Society for Antiviral ResearchRepositório Científico do Instituto Nacional de SaúdeHurt, Aeron C.Besselaar, Terry G.Daniels, Rod S.Ermetal, BurcuFry, AliciaGubareva, LarisaHuang, WeijuanLackenby, AngieLee, Raphael T.C.Lo, JaniceMaurer-Stroh, SebastianNguyen, Ha T.Pereyaslov, DmitriyRebelo-de-Andrade, HelenaSiqueira, Marilda M.Takashita, EmiTashiro, MasatoTilmanis, DanielleWang, DayanZhang, WenqingMeijer, Adam2016-082016-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/4549engAntiviral Res. 2016 Aug;132:178-85. doi: 10.1016/j.antiviral.2016.06.001. Epub 2016 Jun 30166-354210.1016/j.antiviral.2016.06.001info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:40:23Zoai:repositorio.insa.pt:10400.18/4549Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:39:20.054415Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2014-2015 |
title |
Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2014-2015 |
spellingShingle |
Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2014-2015 Hurt, Aeron C. Antiviral Resistance Global Analysis Influenza Virus Neuraminidase Inhibitors Oseltamivir Reduced Susceptibility Resistência aos Antimicrobianos |
title_short |
Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2014-2015 |
title_full |
Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2014-2015 |
title_fullStr |
Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2014-2015 |
title_full_unstemmed |
Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2014-2015 |
title_sort |
Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2014-2015 |
author |
Hurt, Aeron C. |
author_facet |
Hurt, Aeron C. Besselaar, Terry G. Daniels, Rod S. Ermetal, Burcu Fry, Alicia Gubareva, Larisa Huang, Weijuan Lackenby, Angie Lee, Raphael T.C. Lo, Janice Maurer-Stroh, Sebastian Nguyen, Ha T. Pereyaslov, Dmitriy Rebelo-de-Andrade, Helena Siqueira, Marilda M. Takashita, Emi Tashiro, Masato Tilmanis, Danielle Wang, Dayan Zhang, Wenqing Meijer, Adam |
author_role |
author |
author2 |
Besselaar, Terry G. Daniels, Rod S. Ermetal, Burcu Fry, Alicia Gubareva, Larisa Huang, Weijuan Lackenby, Angie Lee, Raphael T.C. Lo, Janice Maurer-Stroh, Sebastian Nguyen, Ha T. Pereyaslov, Dmitriy Rebelo-de-Andrade, Helena Siqueira, Marilda M. Takashita, Emi Tashiro, Masato Tilmanis, Danielle Wang, Dayan Zhang, Wenqing Meijer, Adam |
author2_role |
author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
dc.contributor.author.fl_str_mv |
Hurt, Aeron C. Besselaar, Terry G. Daniels, Rod S. Ermetal, Burcu Fry, Alicia Gubareva, Larisa Huang, Weijuan Lackenby, Angie Lee, Raphael T.C. Lo, Janice Maurer-Stroh, Sebastian Nguyen, Ha T. Pereyaslov, Dmitriy Rebelo-de-Andrade, Helena Siqueira, Marilda M. Takashita, Emi Tashiro, Masato Tilmanis, Danielle Wang, Dayan Zhang, Wenqing Meijer, Adam |
dc.subject.por.fl_str_mv |
Antiviral Resistance Global Analysis Influenza Virus Neuraminidase Inhibitors Oseltamivir Reduced Susceptibility Resistência aos Antimicrobianos |
topic |
Antiviral Resistance Global Analysis Influenza Virus Neuraminidase Inhibitors Oseltamivir Reduced Susceptibility Resistência aos Antimicrobianos |
description |
The World Health Organization (WHO) Collaborating Centres for Reference and Research on Influenza (WHO CCs) tested 13,312 viruses collected by WHO recognized National Influenza Centres between May 2014 and May 2015 to determine 50% inhibitory concentration (IC50) data for neuraminidase inhibitors (NAIs) oseltamivir, zanamivir, peramivir and laninamivir. Ninety-four per cent of the viruses tested by the WHO CCs were from three WHO regions: Western Pacific, the Americas and Europe. Approximately 0.5% (n = 68) of viruses showed either highly reduced inhibition (HRI) or reduced inhibition (RI) (n = 56) against at least one of the four NAIs. Of the twelve viruses with HRI, six were A(H1N1)pdm09 viruses, three were A(H3N2) viruses and three were B/Yamagata-lineage viruses. The overall frequency of viruses with RI or HRI by the NAIs was lower than that observed in 2013-14 (1.9%), but similar to the 2012-13 period (0.6%). Based on the current analysis, the NAIs remain an appropriate choice for the treatment and prophylaxis of influenza virus infections. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-08 2016-08-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/4549 |
url |
http://hdl.handle.net/10400.18/4549 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Antiviral Res. 2016 Aug;132:178-85. doi: 10.1016/j.antiviral.2016.06.001. Epub 2016 Jun 3 0166-3542 10.1016/j.antiviral.2016.06.001 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Masson/ International Society for Antiviral Research |
publisher.none.fl_str_mv |
Elsevier Masson/ International Society for Antiviral Research |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132131997253632 |