Effects of choline on hemorheological properties and NO metabolism of human erythrocytes

Detalhes bibliográficos
Autor(a) principal: Santos, Tiago
Data de Publicação: 2003
Outros Autores: Mesquita, Rui, Martins e Silva, João, Saldanha, Carlota
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/17741
Resumo: © 2003 – IOS Press. All rights reserved
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spelling Effects of choline on hemorheological properties and NO metabolism of human erythrocytesCholineHemorheologyNONitrites© 2003 – IOS Press. All rights reservedPurpose of the study: To determine the effects of choline on red blood cell membrane properties and NO metabolism. Material and methods: Aliquots of venous blood from eleven healthy subjects were incubated in vitro with choline concentrations 10−10 to 10−3 M. The following parameters were determined: erythrocyte deformability, aggregation and membrane lipid fluidity, plasma K+, Na+, Ca2+, total blood haemoglobin and methemoglobin concentrations. Additionally, plasma and intra-erythrocyte nitrites concentrations were measured. Results: Choline increases erythrocyte deformability at lower shear stresses, decreases erythrocyte aggregation, increases membrane lipid fluidity, and decreases of Na+ plasma concentrations. We also find an increase of nitrites concentration both in the plasma and in the intra-erythrocyte compartment. Conclusion: Choline induces changes on erythrocyte membrane properties, Na+ plasma concentration, and NO metabolites concentrations.This study has been supported by a grant of the GAPIC (Department of Scientific Research, of the Faculty of Medicine of Lisbon).IOS PressRepositório da Universidade de LisboaSantos, TiagoMesquita, RuiMartins e Silva, JoãoSaldanha, Carlota2015-03-18T11:58:46Z20032003-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/17741engClinical Hemorheology and Microcirculation 29 (2003) 41–511386-0291http://iospress.metapress.com/content/y1p34rf38jjf49kr/?p=c84fcbaf339c48f996b15e7c4a71cffe&pi=6info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:03:32Zoai:repositorio.ul.pt:10451/17741Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:37:30.765217Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Effects of choline on hemorheological properties and NO metabolism of human erythrocytes
title Effects of choline on hemorheological properties and NO metabolism of human erythrocytes
spellingShingle Effects of choline on hemorheological properties and NO metabolism of human erythrocytes
Santos, Tiago
Choline
Hemorheology
NO
Nitrites
title_short Effects of choline on hemorheological properties and NO metabolism of human erythrocytes
title_full Effects of choline on hemorheological properties and NO metabolism of human erythrocytes
title_fullStr Effects of choline on hemorheological properties and NO metabolism of human erythrocytes
title_full_unstemmed Effects of choline on hemorheological properties and NO metabolism of human erythrocytes
title_sort Effects of choline on hemorheological properties and NO metabolism of human erythrocytes
author Santos, Tiago
author_facet Santos, Tiago
Mesquita, Rui
Martins e Silva, João
Saldanha, Carlota
author_role author
author2 Mesquita, Rui
Martins e Silva, João
Saldanha, Carlota
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Santos, Tiago
Mesquita, Rui
Martins e Silva, João
Saldanha, Carlota
dc.subject.por.fl_str_mv Choline
Hemorheology
NO
Nitrites
topic Choline
Hemorheology
NO
Nitrites
description © 2003 – IOS Press. All rights reserved
publishDate 2003
dc.date.none.fl_str_mv 2003
2003-01-01T00:00:00Z
2015-03-18T11:58:46Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/17741
url http://hdl.handle.net/10451/17741
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Clinical Hemorheology and Microcirculation 29 (2003) 41–51
1386-0291
http://iospress.metapress.com/content/y1p34rf38jjf49kr/?p=c84fcbaf339c48f996b15e7c4a71cffe&pi=6
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv IOS Press
publisher.none.fl_str_mv IOS Press
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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