The relation between the erythrocyte nitric oxide and hemorheological parameters

Detalhes bibliográficos
Autor(a) principal: Carvalho, F. A.
Data de Publicação: 2006
Outros Autores: Maria, A. V., Nogueira, J. M. Braz, Guerra, J., Martins-Silva, J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/20173
Resumo: © 2006 – IOS Press and the authors. All rights reserved
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spelling The relation between the erythrocyte nitric oxide and hemorheological parametersNitric oxideHemorheologyAcetylcholineHypertensionHypercholesterolemiaRenal transplantation© 2006 – IOS Press and the authors. All rights reservedWe stimulated human erythrocytes obtained from patients with hypercholesterolemia (HC; n = 42), renal transplantation (RT; n = 18) and hypertension (HT; n = 10) with acetylcholine (ACh 10 μM) and measured the amperometric NO production, comparing with the NO levels achieved on erythrocytes of healthy persons (n = 27). We also measured the hemoglobin, hematocrit, erythrocyte aggregation, erythrocyte deformability, plasma viscosity and fibrinogen concentration from human blood samples. The erythrocytes NO levels were of 2.5 ± 0.7 nM (P = 0.038, HC), 2.4 ± 1.1 nM (RT) and 2.2 ± 0.8 nM (HT) against the 2.0 ± 0.8 nM for the control groups. For each group and at each shear stress value, the erythrocytes deformability decreases with the increase of the NO concentration after ACh stimulation. We observed a significant increase of the control values on the erythrocyte aggregation results on each patient group. Besides the lower erythrocyte deformability obtained on HC, RT and HT blood samples, the erythrocytes produced higher NO levels after ACh stimulation than the healthy ones. The power of erythrocyte hemorheological behaviour could be compensated by the NO production at the presence of acetylcholine. We can hypothesises that cholinergic drugs could be used as co-adjuvants of specific therapeutics compounds on these studied diseases.This work was supported by “Fundação para a Ciência e Tecnologia”, Portugal.IOS PressRepositório da Universidade de LisboaCarvalho, F. A.Maria, A. V.Nogueira, J. M. BrazGuerra, J.Martins-Silva, J.2015-09-30T14:14:51Z20062006-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/20173engClinical Hemorheology and Microcirculation 35 (2006) 341–3471386-0291http://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch950info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:05:23Zoai:repositorio.ul.pt:10451/20173Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:38:16.638478Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The relation between the erythrocyte nitric oxide and hemorheological parameters
title The relation between the erythrocyte nitric oxide and hemorheological parameters
spellingShingle The relation between the erythrocyte nitric oxide and hemorheological parameters
Carvalho, F. A.
Nitric oxide
Hemorheology
Acetylcholine
Hypertension
Hypercholesterolemia
Renal transplantation
title_short The relation between the erythrocyte nitric oxide and hemorheological parameters
title_full The relation between the erythrocyte nitric oxide and hemorheological parameters
title_fullStr The relation between the erythrocyte nitric oxide and hemorheological parameters
title_full_unstemmed The relation between the erythrocyte nitric oxide and hemorheological parameters
title_sort The relation between the erythrocyte nitric oxide and hemorheological parameters
author Carvalho, F. A.
author_facet Carvalho, F. A.
Maria, A. V.
Nogueira, J. M. Braz
Guerra, J.
Martins-Silva, J.
author_role author
author2 Maria, A. V.
Nogueira, J. M. Braz
Guerra, J.
Martins-Silva, J.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Carvalho, F. A.
Maria, A. V.
Nogueira, J. M. Braz
Guerra, J.
Martins-Silva, J.
dc.subject.por.fl_str_mv Nitric oxide
Hemorheology
Acetylcholine
Hypertension
Hypercholesterolemia
Renal transplantation
topic Nitric oxide
Hemorheology
Acetylcholine
Hypertension
Hypercholesterolemia
Renal transplantation
description © 2006 – IOS Press and the authors. All rights reserved
publishDate 2006
dc.date.none.fl_str_mv 2006
2006-01-01T00:00:00Z
2015-09-30T14:14:51Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/20173
url http://hdl.handle.net/10451/20173
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Clinical Hemorheology and Microcirculation 35 (2006) 341–347
1386-0291
http://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch950
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv IOS Press
publisher.none.fl_str_mv IOS Press
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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