Longitudinal evaluation of hemorheological markers in acute inflammatory diseases

Detalhes bibliográficos
Autor(a) principal: Potapova, Ekaterina Sergueevna
Data de Publicação: 2014
Tipo de documento: Dissertação
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/12310
Resumo: Dissertação para obtenção do Grau de Mestre em Genética Molecular e Biomedicina
id RCAP_46c8310a8f5f1430e5c787f5691e3615
oai_identifier_str oai:run.unl.pt:10362/12310
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Longitudinal evaluation of hemorheological markers in acute inflammatory diseasesInflammationErythrocytesNitric oxideHemorheologyDissertação para obtenção do Grau de Mestre em Genética Molecular e BiomedicinaAcute myocardial infarction (AMI), sepsis and rheumatoid arthritis (RA) are part of the inflammatory diseases’ group. Every year millions of people are affected and die because of them, all around the globe. In the past years our knowledge of these diseases has increased and a light on their pathophysiology has been shed, but there is still much more to be discovered. Biological markers that would make pre-disease diagnosis possible would change many of the outcomes for patients suffering from them. The aim of this study was to access the evolution of four hemorheological markers (erythrocyte deformability, erythrocyte aggregation, nitric oxide – NO and S-nitrosoglutathione – GSNO) in order to understand their behaviour in three types of inflammatory diseases. Four study groups were created: ST-elevation myocardial infarction (STEMI) group (15 patients), RA (25 patients), sepsis (14 patients) and the control group (CTR; 15 healthy volunteers). In STEMI group two different measurements were taken, one at time of hospital admission and the other after a month. In the sepsis group four measurements were taken throughout the internment in the Intensive Care Unit (ICU): admission, 24 hours, 72 hours after and discharge. Significant difference was observed in the 10s erythrocyte aggregation marker between the STEMI patients at hospital admission and CTR group. Significant differences of deformability, aggregation and GSNO were obtained upon comparison of sepsis patients (at all time-points) and CTR. In addition to this, the longitudinal changes of GSNO erythrocyte concentrations were significant. In conclusion, abnormal values for some of the studied hemorheological parameters were verified in inflammatory diseases, namely myocardial infarction (STEMI), sepsis and rheumatoid arthritis. The results seem to point out to a relation between inflammation and the hemorheological alterations.Faculdade de Ciências e TecnologiaNapoleão, PatríciaSaldanha, CarlotaRUNPotapova, Ekaterina Sergueevna2014-07-02T10:04:21Z20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10362/12310enginfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T03:47:14Zoai:run.unl.pt:10362/12310Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:20:51.376209Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Longitudinal evaluation of hemorheological markers in acute inflammatory diseases
title Longitudinal evaluation of hemorheological markers in acute inflammatory diseases
spellingShingle Longitudinal evaluation of hemorheological markers in acute inflammatory diseases
Potapova, Ekaterina Sergueevna
Inflammation
Erythrocytes
Nitric oxide
Hemorheology
title_short Longitudinal evaluation of hemorheological markers in acute inflammatory diseases
title_full Longitudinal evaluation of hemorheological markers in acute inflammatory diseases
title_fullStr Longitudinal evaluation of hemorheological markers in acute inflammatory diseases
title_full_unstemmed Longitudinal evaluation of hemorheological markers in acute inflammatory diseases
title_sort Longitudinal evaluation of hemorheological markers in acute inflammatory diseases
author Potapova, Ekaterina Sergueevna
author_facet Potapova, Ekaterina Sergueevna
author_role author
dc.contributor.none.fl_str_mv Napoleão, Patrícia
Saldanha, Carlota
RUN
dc.contributor.author.fl_str_mv Potapova, Ekaterina Sergueevna
dc.subject.por.fl_str_mv Inflammation
Erythrocytes
Nitric oxide
Hemorheology
topic Inflammation
Erythrocytes
Nitric oxide
Hemorheology
description Dissertação para obtenção do Grau de Mestre em Genética Molecular e Biomedicina
publishDate 2014
dc.date.none.fl_str_mv 2014-07-02T10:04:21Z
2014
2014-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/12310
url http://hdl.handle.net/10362/12310
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Faculdade de Ciências e Tecnologia
publisher.none.fl_str_mv Faculdade de Ciências e Tecnologia
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799137849771032576

Registros relacionados