A new approach based on injection moulding to produce biodegradable starch-based polymeric scaffolds: morphology, mechanical and degradation behaviour

Detalhes bibliográficos
Autor(a) principal: Gomes, Manuela E.
Data de Publicação: 2001
Outros Autores: Ribeiro, A. S., Malafaya, P. B., Reis, R. L., Cunha, A. M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/277
Resumo: http://www.sciencedirect.com/science/journal/01429612
id RCAP_649cbbd78ab8f89a3d4b2098e855a556
oai_identifier_str oai:repositorium.sdum.uminho.pt:1822/277
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling A new approach based on injection moulding to produce biodegradable starch-based polymeric scaffolds: morphology, mechanical and degradation behaviourBiodegradable polymersHard-tissue engineeringStarch-based biomaterialsScaffold processingScience & Technologyhttp://www.sciencedirect.com/science/journal/01429612One of the present challenges in polymer sca!old processing is the fabrication of three-dimensional (3D) architectures with an adequate mechanical performance to be used in the tissue engineering of hard tissues. This paper describes a preliminary study on the development of a new method to produce biodegradable sca!olds from a range of corn-starch-based polymers. In some cases, hydroxlapatite was also used as a einforcement of the biodegradable polymers. The developed methodology consists of a standard conventional injection moulding process, on which a solid blowing agent based on carboxylic acids is used to generate the foaming of the bulk of the moulded part. The proposed route allows for the production of sca!olds with a compact skin and a porous core, with promising mechanical properties. By using the developed method it is possible to manufacture biodegradable polymer sca!olds in an easy (melt-based processing) and reproducible manner. The sca!olds can be moulded into complex shapes, and the blowing additives do not a!ect the non-cytotoxic behaviour of the starch-based materials. The materials produced using this method were evaluated with respect to the morphology of the porous structure, and the respective mechanical properties and degradation behaviour. It was demonstrated that it is possible to obtain, by a standard melt based processing route, 3D sca!olds with complex shapes that exhibit an appropriate morphology, without decreasing signi"cantly the mechanical properties of the materials. It is believed that the optimisation of the proposed processing methodology may lead to the production of sca!olds that might be used on the regeneration of load-bearing tissues.Elsevier ScienceUniversidade do MinhoGomes, Manuela E.Ribeiro, A. S.Malafaya, P. B.Reis, R. L.Cunha, A. M.20012001-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/277eng"Biomaterials". 22:9 (2001) 883-889.0142-961210.1016/S0142-9612(00)00211-811311006info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:27:50Zoai:repositorium.sdum.uminho.pt:1822/277Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:22:32.021557Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv A new approach based on injection moulding to produce biodegradable starch-based polymeric scaffolds: morphology, mechanical and degradation behaviour
title A new approach based on injection moulding to produce biodegradable starch-based polymeric scaffolds: morphology, mechanical and degradation behaviour
spellingShingle A new approach based on injection moulding to produce biodegradable starch-based polymeric scaffolds: morphology, mechanical and degradation behaviour
Gomes, Manuela E.
Biodegradable polymers
Hard-tissue engineering
Starch-based biomaterials
Scaffold processing
Science & Technology
title_short A new approach based on injection moulding to produce biodegradable starch-based polymeric scaffolds: morphology, mechanical and degradation behaviour
title_full A new approach based on injection moulding to produce biodegradable starch-based polymeric scaffolds: morphology, mechanical and degradation behaviour
title_fullStr A new approach based on injection moulding to produce biodegradable starch-based polymeric scaffolds: morphology, mechanical and degradation behaviour
title_full_unstemmed A new approach based on injection moulding to produce biodegradable starch-based polymeric scaffolds: morphology, mechanical and degradation behaviour
title_sort A new approach based on injection moulding to produce biodegradable starch-based polymeric scaffolds: morphology, mechanical and degradation behaviour
author Gomes, Manuela E.
author_facet Gomes, Manuela E.
Ribeiro, A. S.
Malafaya, P. B.
Reis, R. L.
Cunha, A. M.
author_role author
author2 Ribeiro, A. S.
Malafaya, P. B.
Reis, R. L.
Cunha, A. M.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Gomes, Manuela E.
Ribeiro, A. S.
Malafaya, P. B.
Reis, R. L.
Cunha, A. M.
dc.subject.por.fl_str_mv Biodegradable polymers
Hard-tissue engineering
Starch-based biomaterials
Scaffold processing
Science & Technology
topic Biodegradable polymers
Hard-tissue engineering
Starch-based biomaterials
Scaffold processing
Science & Technology
description http://www.sciencedirect.com/science/journal/01429612
publishDate 2001
dc.date.none.fl_str_mv 2001
2001-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/277
url http://hdl.handle.net/1822/277
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv "Biomaterials". 22:9 (2001) 883-889.
0142-9612
10.1016/S0142-9612(00)00211-8
11311006
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799132695942397952

Registros relacionados