Magnetic field dynamic strategies for the improved control of the angiogenic effect of mesenchymal stromal cells
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/144657 |
Resumo: | project PTDC/EDM-EDM/30828/2017 SFRH/BD/114043/2015 co-financed by the ERDF under the PT2020 Partnership Agreement (POVI-01-0145-FEDER-007265), as well as from POR Lisboa 2020 grant PRECISE (Project N. 16394). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
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Magnetic field dynamic strategies for the improved control of the angiogenic effect of mesenchymal stromal cellsAngiogenesisEndothelial cellsMagnetic fieldMagnetic-responsive hydrogelMesenchymal stromal cellsVEGFChemistry(all)Polymers and PlasticsSDG 3 - Good Health and Well-beingproject PTDC/EDM-EDM/30828/2017 SFRH/BD/114043/2015 co-financed by the ERDF under the PT2020 Partnership Agreement (POVI-01-0145-FEDER-007265), as well as from POR Lisboa 2020 grant PRECISE (Project N. 16394). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.This work shows the ability to remotely control the paracrine performance of mesenchymal stromal cells (MSCs) in producing an angiogenesis key molecule, vascular endothelial growth factor (VEGF-A), by modulation of an external magnetic field. This work compares for the first time the application of static and dynamic magnetic fields in angiogenesis in vitro model, exploring the effect of magnetic field intensity and dynamic regimes on the VEGF-A secretion potential of MSCs. Tissue scaffolds of gelatin doped with iron oxide nanoparticles (MNPs) were used as a platform for MSC proliferation. Dynamic magnetic field regimes were imposed by cyclic variation of the magnetic field intensity in different frequencies. The effect of the magnetic field intensity on cell behavior showed that higher intensity of 0.45 T was associated with increased cell death and a poor angiogenic effect. It was observed that static and dynamic magnetic stimulation with higher frequencies led to improved angiogenic performance on endothelial cells in comparison with a lower frequency regime. This work showed the possibility to control VEGF-A secretion by MSCs through modulation of the magnetic field, offering attractive perspectives of a non-invasive therapeutic option for several diseases by revascularizing damaged tissues or inhibiting metastasis formation during cancer progression.LAQV@REQUIMTEDQ - Departamento de QuímicaRUNManjua, Ana C.Cabral, Joaquim M.S.Ferreira, Frederico CasteloPortugal, Carla A.M.2022-10-12T22:15:25Z2021-06-012021-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/144657engPURE: 45610266https://doi.org/10.3390/polym13111883info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:24:25Zoai:run.unl.pt:10362/144657Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:51:40.666810Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Magnetic field dynamic strategies for the improved control of the angiogenic effect of mesenchymal stromal cells |
| title |
Magnetic field dynamic strategies for the improved control of the angiogenic effect of mesenchymal stromal cells |
| spellingShingle |
Magnetic field dynamic strategies for the improved control of the angiogenic effect of mesenchymal stromal cells Manjua, Ana C. Angiogenesis Endothelial cells Magnetic field Magnetic-responsive hydrogel Mesenchymal stromal cells VEGF Chemistry(all) Polymers and Plastics SDG 3 - Good Health and Well-being |
| title_short |
Magnetic field dynamic strategies for the improved control of the angiogenic effect of mesenchymal stromal cells |
| title_full |
Magnetic field dynamic strategies for the improved control of the angiogenic effect of mesenchymal stromal cells |
| title_fullStr |
Magnetic field dynamic strategies for the improved control of the angiogenic effect of mesenchymal stromal cells |
| title_full_unstemmed |
Magnetic field dynamic strategies for the improved control of the angiogenic effect of mesenchymal stromal cells |
| title_sort |
Magnetic field dynamic strategies for the improved control of the angiogenic effect of mesenchymal stromal cells |
| author |
Manjua, Ana C. |
| author_facet |
Manjua, Ana C. Cabral, Joaquim M.S. Ferreira, Frederico Castelo Portugal, Carla A.M. |
| author_role |
author |
| author2 |
Cabral, Joaquim M.S. Ferreira, Frederico Castelo Portugal, Carla A.M. |
| author2_role |
author author author |
| dc.contributor.none.fl_str_mv |
LAQV@REQUIMTE DQ - Departamento de Química RUN |
| dc.contributor.author.fl_str_mv |
Manjua, Ana C. Cabral, Joaquim M.S. Ferreira, Frederico Castelo Portugal, Carla A.M. |
| dc.subject.por.fl_str_mv |
Angiogenesis Endothelial cells Magnetic field Magnetic-responsive hydrogel Mesenchymal stromal cells VEGF Chemistry(all) Polymers and Plastics SDG 3 - Good Health and Well-being |
| topic |
Angiogenesis Endothelial cells Magnetic field Magnetic-responsive hydrogel Mesenchymal stromal cells VEGF Chemistry(all) Polymers and Plastics SDG 3 - Good Health and Well-being |
| description |
project PTDC/EDM-EDM/30828/2017 SFRH/BD/114043/2015 co-financed by the ERDF under the PT2020 Partnership Agreement (POVI-01-0145-FEDER-007265), as well as from POR Lisboa 2020 grant PRECISE (Project N. 16394). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021-06-01 2021-06-01T00:00:00Z 2022-10-12T22:15:25Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/144657 |
| url |
http://hdl.handle.net/10362/144657 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
PURE: 45610266 https://doi.org/10.3390/polym13111883 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
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application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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