Fabrication of calcium phosphates with controlled properties using a modular oscillatory flow reactor
Autor(a) principal: | |
---|---|
Data de Publicação: | 2022 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.14/41301 |
Resumo: | Several technologies and synthesis routes have been implemented to produce calcium phosphates (CaPs) with distinct characteristics for biomedical applications. However, produce CaPs in a controlled way still represents a challenge. Oscillatory flow reactors (OFRs) are a technology ready to deliver in terms of mixing intensification in multiphase systems. In particular, continuous processes in OFRs improve control over the reaction conditions and can be implemented at an industrial scale. The aim of this work was to study for the first time the influence of the oscillation amplitude (x0: 4, 8 and 18 mm) and frequency (f: 1.9, 4 and 6 Hz) as well as residence time (τ: 3.3, 6.6 min) on the final CaP particles’ physicochemical properties using a continuous precipitation process in a novel modular oscillatory flow plate reactor (MOFPR). Furthermore, other parameters such as the initial reagents concentration, initial Ca/P molar ratio (Ca/P = 1.67, 1.33) and temperature (T = 37, 54 ºC) were also assessed. The synthesized particles and overall process were compared with particles obtained using the same methodology in conventional reactors, evidencing the potential of this technology to fabricate CaPs with tailored properties for potential application as nano or microcarriers for biomedical applications. |
id |
RCAP_655d6ec8976037d2963008b0325200b5 |
---|---|
oai_identifier_str |
oai:repositorio.ucp.pt:10400.14/41301 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Fabrication of calcium phosphates with controlled properties using a modular oscillatory flow reactorCalcium phosphatesContinuous processNano and microcarriersOscillatory flow reactorsPrecipitationSeveral technologies and synthesis routes have been implemented to produce calcium phosphates (CaPs) with distinct characteristics for biomedical applications. However, produce CaPs in a controlled way still represents a challenge. Oscillatory flow reactors (OFRs) are a technology ready to deliver in terms of mixing intensification in multiphase systems. In particular, continuous processes in OFRs improve control over the reaction conditions and can be implemented at an industrial scale. The aim of this work was to study for the first time the influence of the oscillation amplitude (x0: 4, 8 and 18 mm) and frequency (f: 1.9, 4 and 6 Hz) as well as residence time (τ: 3.3, 6.6 min) on the final CaP particles’ physicochemical properties using a continuous precipitation process in a novel modular oscillatory flow plate reactor (MOFPR). Furthermore, other parameters such as the initial reagents concentration, initial Ca/P molar ratio (Ca/P = 1.67, 1.33) and temperature (T = 37, 54 ºC) were also assessed. The synthesized particles and overall process were compared with particles obtained using the same methodology in conventional reactors, evidencing the potential of this technology to fabricate CaPs with tailored properties for potential application as nano or microcarriers for biomedical applications.Veritati - Repositório Institucional da Universidade Católica PortuguesaVeiga, AnabelaCastro, FilipaFerreira, AntónioOliveira, Ana L.Rocha, Fernando2023-06-02T11:40:45Z2022-072022-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.14/41301eng0263-876210.1016/j.cherd.2022.04.03685130067254000802674800001info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-16T01:45:06Zoai:repositorio.ucp.pt:10400.14/41301Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:33:57.533785Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Fabrication of calcium phosphates with controlled properties using a modular oscillatory flow reactor |
title |
Fabrication of calcium phosphates with controlled properties using a modular oscillatory flow reactor |
spellingShingle |
Fabrication of calcium phosphates with controlled properties using a modular oscillatory flow reactor Veiga, Anabela Calcium phosphates Continuous process Nano and microcarriers Oscillatory flow reactors Precipitation |
title_short |
Fabrication of calcium phosphates with controlled properties using a modular oscillatory flow reactor |
title_full |
Fabrication of calcium phosphates with controlled properties using a modular oscillatory flow reactor |
title_fullStr |
Fabrication of calcium phosphates with controlled properties using a modular oscillatory flow reactor |
title_full_unstemmed |
Fabrication of calcium phosphates with controlled properties using a modular oscillatory flow reactor |
title_sort |
Fabrication of calcium phosphates with controlled properties using a modular oscillatory flow reactor |
author |
Veiga, Anabela |
author_facet |
Veiga, Anabela Castro, Filipa Ferreira, António Oliveira, Ana L. Rocha, Fernando |
author_role |
author |
author2 |
Castro, Filipa Ferreira, António Oliveira, Ana L. Rocha, Fernando |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Veritati - Repositório Institucional da Universidade Católica Portuguesa |
dc.contributor.author.fl_str_mv |
Veiga, Anabela Castro, Filipa Ferreira, António Oliveira, Ana L. Rocha, Fernando |
dc.subject.por.fl_str_mv |
Calcium phosphates Continuous process Nano and microcarriers Oscillatory flow reactors Precipitation |
topic |
Calcium phosphates Continuous process Nano and microcarriers Oscillatory flow reactors Precipitation |
description |
Several technologies and synthesis routes have been implemented to produce calcium phosphates (CaPs) with distinct characteristics for biomedical applications. However, produce CaPs in a controlled way still represents a challenge. Oscillatory flow reactors (OFRs) are a technology ready to deliver in terms of mixing intensification in multiphase systems. In particular, continuous processes in OFRs improve control over the reaction conditions and can be implemented at an industrial scale. The aim of this work was to study for the first time the influence of the oscillation amplitude (x0: 4, 8 and 18 mm) and frequency (f: 1.9, 4 and 6 Hz) as well as residence time (τ: 3.3, 6.6 min) on the final CaP particles’ physicochemical properties using a continuous precipitation process in a novel modular oscillatory flow plate reactor (MOFPR). Furthermore, other parameters such as the initial reagents concentration, initial Ca/P molar ratio (Ca/P = 1.67, 1.33) and temperature (T = 37, 54 ºC) were also assessed. The synthesized particles and overall process were compared with particles obtained using the same methodology in conventional reactors, evidencing the potential of this technology to fabricate CaPs with tailored properties for potential application as nano or microcarriers for biomedical applications. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-07 2022-07-01T00:00:00Z 2023-06-02T11:40:45Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.14/41301 |
url |
http://hdl.handle.net/10400.14/41301 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0263-8762 10.1016/j.cherd.2022.04.036 85130067254 000802674800001 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799132066435039232 |