Congenital or neonatal cytomegalovirus infection?.

Detalhes bibliográficos
Autor(a) principal: Graça, André
Data de Publicação: 2004
Outros Autores: Silvério, Cristina, Ferreira, José P, Brito, Anabela, Almeida, Sofia, Paixão, Paulo, Pinheiro, Luís
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1090
Resumo: Congenital Cytomegalovirus (CMV) infection occurs in about 1% of the newborns, but it is clinically unapparent in around 90% of the cases during the newborn period. This congenital infection may be the cause of neurological sequelae of variable severity, namely neuro-sensorial hearing loss. In most cases of hearing loss secondary to congenital CMV infection, the newborn was asymptomatic. The diagnosis of congenital CMV infection is made traditionally by culturing the virus from urine during the first three weeks of life. In the present case, the authors describe the situation of a two months old black female infant, admitted for irritability, vomiting and generalized convulsions. During investigation, the authors found lab results in favor of recent CMV infection. The imaging studies performed (cerebral ultrasound scan, computerized tomography and magnetic resonance imaging) were normal. As the infant was older than three weeks, it was not possible to make the diagnosis of congenital CMV infection by a positive urine sample. The diagnosis was made by a positive Polymerase Chain Reaction made on the Guthrie card, collected on the fifth day of life and archived in the national laboratory that centralizes the early diagnosis of phenylketonuria and hypothyroidism. The authors review the epidemiology, diagnosis, prognosis and prevention of the congenital CMV infection, giving a perspective of the magnitude of this disease, its sequelae and the new diagnostic methods available, even when the infection is clinically unapparent on the newborn period.
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spelling Congenital or neonatal cytomegalovirus infection?.Citomegalovirus. Infecção congénita ou neonatal?Congenital Cytomegalovirus (CMV) infection occurs in about 1% of the newborns, but it is clinically unapparent in around 90% of the cases during the newborn period. This congenital infection may be the cause of neurological sequelae of variable severity, namely neuro-sensorial hearing loss. In most cases of hearing loss secondary to congenital CMV infection, the newborn was asymptomatic. The diagnosis of congenital CMV infection is made traditionally by culturing the virus from urine during the first three weeks of life. In the present case, the authors describe the situation of a two months old black female infant, admitted for irritability, vomiting and generalized convulsions. During investigation, the authors found lab results in favor of recent CMV infection. The imaging studies performed (cerebral ultrasound scan, computerized tomography and magnetic resonance imaging) were normal. As the infant was older than three weeks, it was not possible to make the diagnosis of congenital CMV infection by a positive urine sample. The diagnosis was made by a positive Polymerase Chain Reaction made on the Guthrie card, collected on the fifth day of life and archived in the national laboratory that centralizes the early diagnosis of phenylketonuria and hypothyroidism. The authors review the epidemiology, diagnosis, prognosis and prevention of the congenital CMV infection, giving a perspective of the magnitude of this disease, its sequelae and the new diagnostic methods available, even when the infection is clinically unapparent on the newborn period.Congenital Cytomegalovirus (CMV) infection occurs in about 1% of the newborns, but it is clinically unapparent in around 90% of the cases during the newborn period. This congenital infection may be the cause of neurological sequelae of variable severity, namely neuro-sensorial hearing loss. In most cases of hearing loss secondary to congenital CMV infection, the newborn was asymptomatic. The diagnosis of congenital CMV infection is made traditionally by culturing the virus from urine during the first three weeks of life. In the present case, the authors describe the situation of a two months old black female infant, admitted for irritability, vomiting and generalized convulsions. During investigation, the authors found lab results in favor of recent CMV infection. The imaging studies performed (cerebral ultrasound scan, computerized tomography and magnetic resonance imaging) were normal. As the infant was older than three weeks, it was not possible to make the diagnosis of congenital CMV infection by a positive urine sample. The diagnosis was made by a positive Polymerase Chain Reaction made on the Guthrie card, collected on the fifth day of life and archived in the national laboratory that centralizes the early diagnosis of phenylketonuria and hypothyroidism. The authors review the epidemiology, diagnosis, prognosis and prevention of the congenital CMV infection, giving a perspective of the magnitude of this disease, its sequelae and the new diagnostic methods available, even when the infection is clinically unapparent on the newborn period.Ordem dos Médicos2004-08-31info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1090oai:ojs.www.actamedicaportuguesa.com:article/1090Acta Médica Portuguesa; Vol. 17 No. 4 (2004): July-August; 335-40Acta Médica Portuguesa; Vol. 17 N.º 4 (2004): Julho-Agosto; 335-401646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1090https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1090/755Graça, AndréSilvério, CristinaFerreira, José PBrito, AnabelaAlmeida, SofiaPaixão, PauloPinheiro, Luísinfo:eu-repo/semantics/openAccess2022-12-20T10:57:26Zoai:ojs.www.actamedicaportuguesa.com:article/1090Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:16:57.422927Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Congenital or neonatal cytomegalovirus infection?.
Citomegalovirus. Infecção congénita ou neonatal?
title Congenital or neonatal cytomegalovirus infection?.
spellingShingle Congenital or neonatal cytomegalovirus infection?.
Graça, André
title_short Congenital or neonatal cytomegalovirus infection?.
title_full Congenital or neonatal cytomegalovirus infection?.
title_fullStr Congenital or neonatal cytomegalovirus infection?.
title_full_unstemmed Congenital or neonatal cytomegalovirus infection?.
title_sort Congenital or neonatal cytomegalovirus infection?.
author Graça, André
author_facet Graça, André
Silvério, Cristina
Ferreira, José P
Brito, Anabela
Almeida, Sofia
Paixão, Paulo
Pinheiro, Luís
author_role author
author2 Silvério, Cristina
Ferreira, José P
Brito, Anabela
Almeida, Sofia
Paixão, Paulo
Pinheiro, Luís
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Graça, André
Silvério, Cristina
Ferreira, José P
Brito, Anabela
Almeida, Sofia
Paixão, Paulo
Pinheiro, Luís
description Congenital Cytomegalovirus (CMV) infection occurs in about 1% of the newborns, but it is clinically unapparent in around 90% of the cases during the newborn period. This congenital infection may be the cause of neurological sequelae of variable severity, namely neuro-sensorial hearing loss. In most cases of hearing loss secondary to congenital CMV infection, the newborn was asymptomatic. The diagnosis of congenital CMV infection is made traditionally by culturing the virus from urine during the first three weeks of life. In the present case, the authors describe the situation of a two months old black female infant, admitted for irritability, vomiting and generalized convulsions. During investigation, the authors found lab results in favor of recent CMV infection. The imaging studies performed (cerebral ultrasound scan, computerized tomography and magnetic resonance imaging) were normal. As the infant was older than three weeks, it was not possible to make the diagnosis of congenital CMV infection by a positive urine sample. The diagnosis was made by a positive Polymerase Chain Reaction made on the Guthrie card, collected on the fifth day of life and archived in the national laboratory that centralizes the early diagnosis of phenylketonuria and hypothyroidism. The authors review the epidemiology, diagnosis, prognosis and prevention of the congenital CMV infection, giving a perspective of the magnitude of this disease, its sequelae and the new diagnostic methods available, even when the infection is clinically unapparent on the newborn period.
publishDate 2004
dc.date.none.fl_str_mv 2004-08-31
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1090/755
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dc.publisher.none.fl_str_mv Ordem dos Médicos
publisher.none.fl_str_mv Ordem dos Médicos
dc.source.none.fl_str_mv Acta Médica Portuguesa; Vol. 17 No. 4 (2004): July-August; 335-40
Acta Médica Portuguesa; Vol. 17 N.º 4 (2004): Julho-Agosto; 335-40
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0870-399X
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