Congenital or neonatal cytomegalovirus infection?.
Autor(a) principal: | |
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Data de Publicação: | 2004 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1090 |
Resumo: | Congenital Cytomegalovirus (CMV) infection occurs in about 1% of the newborns, but it is clinically unapparent in around 90% of the cases during the newborn period. This congenital infection may be the cause of neurological sequelae of variable severity, namely neuro-sensorial hearing loss. In most cases of hearing loss secondary to congenital CMV infection, the newborn was asymptomatic. The diagnosis of congenital CMV infection is made traditionally by culturing the virus from urine during the first three weeks of life. In the present case, the authors describe the situation of a two months old black female infant, admitted for irritability, vomiting and generalized convulsions. During investigation, the authors found lab results in favor of recent CMV infection. The imaging studies performed (cerebral ultrasound scan, computerized tomography and magnetic resonance imaging) were normal. As the infant was older than three weeks, it was not possible to make the diagnosis of congenital CMV infection by a positive urine sample. The diagnosis was made by a positive Polymerase Chain Reaction made on the Guthrie card, collected on the fifth day of life and archived in the national laboratory that centralizes the early diagnosis of phenylketonuria and hypothyroidism. The authors review the epidemiology, diagnosis, prognosis and prevention of the congenital CMV infection, giving a perspective of the magnitude of this disease, its sequelae and the new diagnostic methods available, even when the infection is clinically unapparent on the newborn period. |
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Congenital or neonatal cytomegalovirus infection?.Citomegalovirus. Infecção congénita ou neonatal?Congenital Cytomegalovirus (CMV) infection occurs in about 1% of the newborns, but it is clinically unapparent in around 90% of the cases during the newborn period. This congenital infection may be the cause of neurological sequelae of variable severity, namely neuro-sensorial hearing loss. In most cases of hearing loss secondary to congenital CMV infection, the newborn was asymptomatic. The diagnosis of congenital CMV infection is made traditionally by culturing the virus from urine during the first three weeks of life. In the present case, the authors describe the situation of a two months old black female infant, admitted for irritability, vomiting and generalized convulsions. During investigation, the authors found lab results in favor of recent CMV infection. The imaging studies performed (cerebral ultrasound scan, computerized tomography and magnetic resonance imaging) were normal. As the infant was older than three weeks, it was not possible to make the diagnosis of congenital CMV infection by a positive urine sample. The diagnosis was made by a positive Polymerase Chain Reaction made on the Guthrie card, collected on the fifth day of life and archived in the national laboratory that centralizes the early diagnosis of phenylketonuria and hypothyroidism. The authors review the epidemiology, diagnosis, prognosis and prevention of the congenital CMV infection, giving a perspective of the magnitude of this disease, its sequelae and the new diagnostic methods available, even when the infection is clinically unapparent on the newborn period.Congenital Cytomegalovirus (CMV) infection occurs in about 1% of the newborns, but it is clinically unapparent in around 90% of the cases during the newborn period. This congenital infection may be the cause of neurological sequelae of variable severity, namely neuro-sensorial hearing loss. In most cases of hearing loss secondary to congenital CMV infection, the newborn was asymptomatic. The diagnosis of congenital CMV infection is made traditionally by culturing the virus from urine during the first three weeks of life. In the present case, the authors describe the situation of a two months old black female infant, admitted for irritability, vomiting and generalized convulsions. During investigation, the authors found lab results in favor of recent CMV infection. The imaging studies performed (cerebral ultrasound scan, computerized tomography and magnetic resonance imaging) were normal. As the infant was older than three weeks, it was not possible to make the diagnosis of congenital CMV infection by a positive urine sample. The diagnosis was made by a positive Polymerase Chain Reaction made on the Guthrie card, collected on the fifth day of life and archived in the national laboratory that centralizes the early diagnosis of phenylketonuria and hypothyroidism. The authors review the epidemiology, diagnosis, prognosis and prevention of the congenital CMV infection, giving a perspective of the magnitude of this disease, its sequelae and the new diagnostic methods available, even when the infection is clinically unapparent on the newborn period.Ordem dos Médicos2004-08-31info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1090oai:ojs.www.actamedicaportuguesa.com:article/1090Acta Médica Portuguesa; Vol. 17 No. 4 (2004): July-August; 335-40Acta Médica Portuguesa; Vol. 17 N.º 4 (2004): Julho-Agosto; 335-401646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1090https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1090/755Graça, AndréSilvério, CristinaFerreira, José PBrito, AnabelaAlmeida, SofiaPaixão, PauloPinheiro, Luísinfo:eu-repo/semantics/openAccess2022-12-20T10:57:26Zoai:ojs.www.actamedicaportuguesa.com:article/1090Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:16:57.422927Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Congenital or neonatal cytomegalovirus infection?. Citomegalovirus. Infecção congénita ou neonatal? |
title |
Congenital or neonatal cytomegalovirus infection?. |
spellingShingle |
Congenital or neonatal cytomegalovirus infection?. Graça, André |
title_short |
Congenital or neonatal cytomegalovirus infection?. |
title_full |
Congenital or neonatal cytomegalovirus infection?. |
title_fullStr |
Congenital or neonatal cytomegalovirus infection?. |
title_full_unstemmed |
Congenital or neonatal cytomegalovirus infection?. |
title_sort |
Congenital or neonatal cytomegalovirus infection?. |
author |
Graça, André |
author_facet |
Graça, André Silvério, Cristina Ferreira, José P Brito, Anabela Almeida, Sofia Paixão, Paulo Pinheiro, Luís |
author_role |
author |
author2 |
Silvério, Cristina Ferreira, José P Brito, Anabela Almeida, Sofia Paixão, Paulo Pinheiro, Luís |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Graça, André Silvério, Cristina Ferreira, José P Brito, Anabela Almeida, Sofia Paixão, Paulo Pinheiro, Luís |
description |
Congenital Cytomegalovirus (CMV) infection occurs in about 1% of the newborns, but it is clinically unapparent in around 90% of the cases during the newborn period. This congenital infection may be the cause of neurological sequelae of variable severity, namely neuro-sensorial hearing loss. In most cases of hearing loss secondary to congenital CMV infection, the newborn was asymptomatic. The diagnosis of congenital CMV infection is made traditionally by culturing the virus from urine during the first three weeks of life. In the present case, the authors describe the situation of a two months old black female infant, admitted for irritability, vomiting and generalized convulsions. During investigation, the authors found lab results in favor of recent CMV infection. The imaging studies performed (cerebral ultrasound scan, computerized tomography and magnetic resonance imaging) were normal. As the infant was older than three weeks, it was not possible to make the diagnosis of congenital CMV infection by a positive urine sample. The diagnosis was made by a positive Polymerase Chain Reaction made on the Guthrie card, collected on the fifth day of life and archived in the national laboratory that centralizes the early diagnosis of phenylketonuria and hypothyroidism. The authors review the epidemiology, diagnosis, prognosis and prevention of the congenital CMV infection, giving a perspective of the magnitude of this disease, its sequelae and the new diagnostic methods available, even when the infection is clinically unapparent on the newborn period. |
publishDate |
2004 |
dc.date.none.fl_str_mv |
2004-08-31 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1090 oai:ojs.www.actamedicaportuguesa.com:article/1090 |
url |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1090 |
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oai:ojs.www.actamedicaportuguesa.com:article/1090 |
dc.language.iso.fl_str_mv |
por |
language |
por |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1090 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1090/755 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Ordem dos Médicos |
publisher.none.fl_str_mv |
Ordem dos Médicos |
dc.source.none.fl_str_mv |
Acta Médica Portuguesa; Vol. 17 No. 4 (2004): July-August; 335-40 Acta Médica Portuguesa; Vol. 17 N.º 4 (2004): Julho-Agosto; 335-40 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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