Polymerizable matrix metalloproteinases’ inhibitors with potential application for dental restorations
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/145949 |
Resumo: | Funding Information: This research was funded by A Molecular View of Dental Restoration, grant number PTDC/SAU-BMA/122444/2010 and by Molecular Design for Dental Restauration, grant number SAICT-POL/24288/2016. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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7160 |
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Polymerizable matrix metalloproteinases’ inhibitors with potential application for dental restorationsCytotoxicityInhibitors of matrix metalloproteinasesMatrixMetalloproteinasesMedicine (miscellaneous)Biochemistry, Genetics and Molecular Biology(all)Funding Information: This research was funded by A Molecular View of Dental Restoration, grant number PTDC/SAU-BMA/122444/2010 and by Molecular Design for Dental Restauration, grant number SAICT-POL/24288/2016. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.Collagen cleavage by matrix metalloproteinase (MMP) is considered a major cause of dental resins long term failure. Most MMP inhibitors display significant toxicity and are unsuitable for dental resins’ applications. Here we report a study of a new class of inhibitors that display the unique property of being co-polymerizable with other vinyl compounds present in commercial dental resins, limiting their release and potential toxicity. Computational affinity towards the active site of different MMP-1;-2;-8;-9 and-13 of several compounds showed interesting properties and were synthesized. These free compounds were tested concerning their toxicity upon contact with two different cell types, with no substantial decrease in cell viability at high concentrations. Even so, compound’s safety can be further improved upon copolymerization with commercial dental resins, limiting their release.UCIBIO - Applied Molecular Biosciences UnitLAQV@REQUIMTERUNLaronha, HelenaCarpinteiro, InêsPortugal, JaimeAzul, AnaPolido, MárioPetrova, Krasimira T.Salema-Oom, MadalenaBarahona, IsabelCaldeira, Jorge2022-12-02T22:14:06Z2021-03-312021-03-31T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article20application/pdfhttp://hdl.handle.net/10362/145949eng2227-9059PURE: 45575058https://doi.org/10.3390/biomedicines9040366info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:26:48Zoai:run.unl.pt:10362/145949Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:52:21.682055Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Polymerizable matrix metalloproteinases’ inhibitors with potential application for dental restorations |
title |
Polymerizable matrix metalloproteinases’ inhibitors with potential application for dental restorations |
spellingShingle |
Polymerizable matrix metalloproteinases’ inhibitors with potential application for dental restorations Laronha, Helena Cytotoxicity Inhibitors of matrix metalloproteinases Matrix Metalloproteinases Medicine (miscellaneous) Biochemistry, Genetics and Molecular Biology(all) |
title_short |
Polymerizable matrix metalloproteinases’ inhibitors with potential application for dental restorations |
title_full |
Polymerizable matrix metalloproteinases’ inhibitors with potential application for dental restorations |
title_fullStr |
Polymerizable matrix metalloproteinases’ inhibitors with potential application for dental restorations |
title_full_unstemmed |
Polymerizable matrix metalloproteinases’ inhibitors with potential application for dental restorations |
title_sort |
Polymerizable matrix metalloproteinases’ inhibitors with potential application for dental restorations |
author |
Laronha, Helena |
author_facet |
Laronha, Helena Carpinteiro, Inês Portugal, Jaime Azul, Ana Polido, Mário Petrova, Krasimira T. Salema-Oom, Madalena Barahona, Isabel Caldeira, Jorge |
author_role |
author |
author2 |
Carpinteiro, Inês Portugal, Jaime Azul, Ana Polido, Mário Petrova, Krasimira T. Salema-Oom, Madalena Barahona, Isabel Caldeira, Jorge |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
UCIBIO - Applied Molecular Biosciences Unit LAQV@REQUIMTE RUN |
dc.contributor.author.fl_str_mv |
Laronha, Helena Carpinteiro, Inês Portugal, Jaime Azul, Ana Polido, Mário Petrova, Krasimira T. Salema-Oom, Madalena Barahona, Isabel Caldeira, Jorge |
dc.subject.por.fl_str_mv |
Cytotoxicity Inhibitors of matrix metalloproteinases Matrix Metalloproteinases Medicine (miscellaneous) Biochemistry, Genetics and Molecular Biology(all) |
topic |
Cytotoxicity Inhibitors of matrix metalloproteinases Matrix Metalloproteinases Medicine (miscellaneous) Biochemistry, Genetics and Molecular Biology(all) |
description |
Funding Information: This research was funded by A Molecular View of Dental Restoration, grant number PTDC/SAU-BMA/122444/2010 and by Molecular Design for Dental Restauration, grant number SAICT-POL/24288/2016. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-03-31 2021-03-31T00:00:00Z 2022-12-02T22:14:06Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/145949 |
url |
http://hdl.handle.net/10362/145949 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2227-9059 PURE: 45575058 https://doi.org/10.3390/biomedicines9040366 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
20 application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799138115120529408 |