The diagnostic and prognostic role of liquid-based cytology: are we ready to monitor therapy and resistance?
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/40521 |
Resumo: | Here, we evaluate the diagnostic and prognostic role of liquid-based cytology (LBC) in different body lesions, including thyroid, lung, effusions and malignant breast lesions. LBC has gained consensus after being applied to both non-gynecologic and fine-needle aspiration cytology. Although some remain sceptical regarding the diagnostic efficacy of LBC, mainly when used alone, in recent years, good results have been obtained as long as it showed a high diagnostic accuracy. Here, we discuss the additional possibility of storing material for the application of ancillary techniques (immunocytochemistry–molecular analysis) with several diagnostic and prognostic advantages, which may pave the way for the challenging evaluation of both monitoring responses to treatment and resistance to targeted therapies in thyroid, lung, breast carcinoma or malignant effusions. Furthermore, it provides the use of several molecular spots as specific targets for personalized therapy. |
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The diagnostic and prognostic role of liquid-based cytology: are we ready to monitor therapy and resistance?EffusionsImmunocytochemistryLiquid-based cytologyMalignancyMolecular analysisNodular lesionstargeted therapiesScience & TechnologyHere, we evaluate the diagnostic and prognostic role of liquid-based cytology (LBC) in different body lesions, including thyroid, lung, effusions and malignant breast lesions. LBC has gained consensus after being applied to both non-gynecologic and fine-needle aspiration cytology. Although some remain sceptical regarding the diagnostic efficacy of LBC, mainly when used alone, in recent years, good results have been obtained as long as it showed a high diagnostic accuracy. Here, we discuss the additional possibility of storing material for the application of ancillary techniques (immunocytochemistry–molecular analysis) with several diagnostic and prognostic advantages, which may pave the way for the challenging evaluation of both monitoring responses to treatment and resistance to targeted therapies in thyroid, lung, breast carcinoma or malignant effusions. Furthermore, it provides the use of several molecular spots as specific targets for personalized therapy.Taylor and FrancisUniversidade do MinhoRossi, Esther DianaBizzarro, TommasoLongatto Filho, AdhemarGerhard, ReneSchmitt, Fernando20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/40521engRossi, E. D., Bizzarro, T., Longatto-Filho, A., Gerhard, R., & Schmitt, F. (2015). The diagnostic and prognostic role of liquid-based cytology: are we ready to monitor therapy and resistance? Expert Review of Anticancer Therapy, 15(8), 911-921. doi: 10.1586/14737140.2015.10538741473-714010.1586/14737140.2015.105387426204907http://www.tandfonline.com/doi/abs/10.1586/14737140.2015.1053874?journalCode=iery20info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:36:47Zoai:repositorium.sdum.uminho.pt:1822/40521Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:32:57.572308Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The diagnostic and prognostic role of liquid-based cytology: are we ready to monitor therapy and resistance? |
title |
The diagnostic and prognostic role of liquid-based cytology: are we ready to monitor therapy and resistance? |
spellingShingle |
The diagnostic and prognostic role of liquid-based cytology: are we ready to monitor therapy and resistance? Rossi, Esther Diana Effusions Immunocytochemistry Liquid-based cytology Malignancy Molecular analysis Nodular lesions targeted therapies Science & Technology |
title_short |
The diagnostic and prognostic role of liquid-based cytology: are we ready to monitor therapy and resistance? |
title_full |
The diagnostic and prognostic role of liquid-based cytology: are we ready to monitor therapy and resistance? |
title_fullStr |
The diagnostic and prognostic role of liquid-based cytology: are we ready to monitor therapy and resistance? |
title_full_unstemmed |
The diagnostic and prognostic role of liquid-based cytology: are we ready to monitor therapy and resistance? |
title_sort |
The diagnostic and prognostic role of liquid-based cytology: are we ready to monitor therapy and resistance? |
author |
Rossi, Esther Diana |
author_facet |
Rossi, Esther Diana Bizzarro, Tommaso Longatto Filho, Adhemar Gerhard, Rene Schmitt, Fernando |
author_role |
author |
author2 |
Bizzarro, Tommaso Longatto Filho, Adhemar Gerhard, Rene Schmitt, Fernando |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Rossi, Esther Diana Bizzarro, Tommaso Longatto Filho, Adhemar Gerhard, Rene Schmitt, Fernando |
dc.subject.por.fl_str_mv |
Effusions Immunocytochemistry Liquid-based cytology Malignancy Molecular analysis Nodular lesions targeted therapies Science & Technology |
topic |
Effusions Immunocytochemistry Liquid-based cytology Malignancy Molecular analysis Nodular lesions targeted therapies Science & Technology |
description |
Here, we evaluate the diagnostic and prognostic role of liquid-based cytology (LBC) in different body lesions, including thyroid, lung, effusions and malignant breast lesions. LBC has gained consensus after being applied to both non-gynecologic and fine-needle aspiration cytology. Although some remain sceptical regarding the diagnostic efficacy of LBC, mainly when used alone, in recent years, good results have been obtained as long as it showed a high diagnostic accuracy. Here, we discuss the additional possibility of storing material for the application of ancillary techniques (immunocytochemistry–molecular analysis) with several diagnostic and prognostic advantages, which may pave the way for the challenging evaluation of both monitoring responses to treatment and resistance to targeted therapies in thyroid, lung, breast carcinoma or malignant effusions. Furthermore, it provides the use of several molecular spots as specific targets for personalized therapy. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015 2015-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/40521 |
url |
http://hdl.handle.net/1822/40521 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Rossi, E. D., Bizzarro, T., Longatto-Filho, A., Gerhard, R., & Schmitt, F. (2015). The diagnostic and prognostic role of liquid-based cytology: are we ready to monitor therapy and resistance? Expert Review of Anticancer Therapy, 15(8), 911-921. doi: 10.1586/14737140.2015.1053874 1473-7140 10.1586/14737140.2015.1053874 26204907 http://www.tandfonline.com/doi/abs/10.1586/14737140.2015.1053874?journalCode=iery20 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Taylor and Francis |
publisher.none.fl_str_mv |
Taylor and Francis |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
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1799132845341409280 |