Microfluidic Organ/Body-on-a-Chip Devices at the Convergence of Biology and Microengineering
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.1/11205 |
Resumo: | Recent advances in biomedical technologies are mostly related to the convergence of biology with microengineering. For instance, microfluidic devices are now commonly found in most research centers, clinics and hospitals, contributing to more accurate studies and therapies as powerful tools for drug delivery, monitoring of specific analytes, and medical diagnostics. Most remarkably, integration of cellularized constructs within microengineered platforms has enabled the recapitulation of the physiological and pathological conditions of complex tissues and organs. The so-called organ-on-a-chip technology, which represents a new avenue in the field of advanced in vitro models, with the potential to revolutionize current approaches to drug screening and toxicology studies. This review aims to highlight recent advances of microfluidic-based devices towards a body-on-a-chip concept, exploring their technology and broad applications in the biomedical field. |
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Microfluidic Organ/Body-on-a-Chip Devices at the Convergence of Biology and MicroengineeringCirculating tumor-cellsIn-Vitro modelReal-time PcrStem-cellsCancer patientsBreast-cancerGene-expressionLabel-freeCapillary-ElectrophoresisEpithelial-cellsRecent advances in biomedical technologies are mostly related to the convergence of biology with microengineering. For instance, microfluidic devices are now commonly found in most research centers, clinics and hospitals, contributing to more accurate studies and therapies as powerful tools for drug delivery, monitoring of specific analytes, and medical diagnostics. Most remarkably, integration of cellularized constructs within microengineered platforms has enabled the recapitulation of the physiological and pathological conditions of complex tissues and organs. The so-called organ-on-a-chip technology, which represents a new avenue in the field of advanced in vitro models, with the potential to revolutionize current approaches to drug screening and toxicology studies. This review aims to highlight recent advances of microfluidic-based devices towards a body-on-a-chip concept, exploring their technology and broad applications in the biomedical field.European Regional Development Fund-Project FNUSA-ICRC [CZ.1.05/1.1.00/02.0123]; Fundacao para a Ciencia e a Tecnologia (FCT), Portugal [UID/BIM/04773/2013]; Internal Research Grant Program, Universita Campus Bio-Medico di RomaMDPI AgSapientiaPerestrelo, Ana RubinaÁguas, Ana C. P.Rainer, AlbertoForte, Giancarlo2018-12-07T14:52:46Z2015-122015-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.1/11205eng1424-822010.3390/s151229848info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-24T10:22:58Zoai:sapientia.ualg.pt:10400.1/11205Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:02:42.918262Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Microfluidic Organ/Body-on-a-Chip Devices at the Convergence of Biology and Microengineering |
title |
Microfluidic Organ/Body-on-a-Chip Devices at the Convergence of Biology and Microengineering |
spellingShingle |
Microfluidic Organ/Body-on-a-Chip Devices at the Convergence of Biology and Microengineering Perestrelo, Ana Rubina Circulating tumor-cells In-Vitro model Real-time Pcr Stem-cells Cancer patients Breast-cancer Gene-expression Label-free Capillary-Electrophoresis Epithelial-cells |
title_short |
Microfluidic Organ/Body-on-a-Chip Devices at the Convergence of Biology and Microengineering |
title_full |
Microfluidic Organ/Body-on-a-Chip Devices at the Convergence of Biology and Microengineering |
title_fullStr |
Microfluidic Organ/Body-on-a-Chip Devices at the Convergence of Biology and Microengineering |
title_full_unstemmed |
Microfluidic Organ/Body-on-a-Chip Devices at the Convergence of Biology and Microengineering |
title_sort |
Microfluidic Organ/Body-on-a-Chip Devices at the Convergence of Biology and Microengineering |
author |
Perestrelo, Ana Rubina |
author_facet |
Perestrelo, Ana Rubina Águas, Ana C. P. Rainer, Alberto Forte, Giancarlo |
author_role |
author |
author2 |
Águas, Ana C. P. Rainer, Alberto Forte, Giancarlo |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Sapientia |
dc.contributor.author.fl_str_mv |
Perestrelo, Ana Rubina Águas, Ana C. P. Rainer, Alberto Forte, Giancarlo |
dc.subject.por.fl_str_mv |
Circulating tumor-cells In-Vitro model Real-time Pcr Stem-cells Cancer patients Breast-cancer Gene-expression Label-free Capillary-Electrophoresis Epithelial-cells |
topic |
Circulating tumor-cells In-Vitro model Real-time Pcr Stem-cells Cancer patients Breast-cancer Gene-expression Label-free Capillary-Electrophoresis Epithelial-cells |
description |
Recent advances in biomedical technologies are mostly related to the convergence of biology with microengineering. For instance, microfluidic devices are now commonly found in most research centers, clinics and hospitals, contributing to more accurate studies and therapies as powerful tools for drug delivery, monitoring of specific analytes, and medical diagnostics. Most remarkably, integration of cellularized constructs within microengineered platforms has enabled the recapitulation of the physiological and pathological conditions of complex tissues and organs. The so-called organ-on-a-chip technology, which represents a new avenue in the field of advanced in vitro models, with the potential to revolutionize current approaches to drug screening and toxicology studies. This review aims to highlight recent advances of microfluidic-based devices towards a body-on-a-chip concept, exploring their technology and broad applications in the biomedical field. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-12 2015-12-01T00:00:00Z 2018-12-07T14:52:46Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.1/11205 |
url |
http://hdl.handle.net/10400.1/11205 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1424-8220 10.3390/s151229848 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI Ag |
publisher.none.fl_str_mv |
MDPI Ag |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133261639712768 |