Microfluidic Organ/Body-on-a-Chip Devices at the Convergence of Biology and Microengineering

Detalhes bibliográficos
Autor(a) principal: Perestrelo, Ana Rubina
Data de Publicação: 2015
Outros Autores: Águas, Ana C. P., Rainer, Alberto, Forte, Giancarlo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.1/11205
Resumo: Recent advances in biomedical technologies are mostly related to the convergence of biology with microengineering. For instance, microfluidic devices are now commonly found in most research centers, clinics and hospitals, contributing to more accurate studies and therapies as powerful tools for drug delivery, monitoring of specific analytes, and medical diagnostics. Most remarkably, integration of cellularized constructs within microengineered platforms has enabled the recapitulation of the physiological and pathological conditions of complex tissues and organs. The so-called organ-on-a-chip technology, which represents a new avenue in the field of advanced in vitro models, with the potential to revolutionize current approaches to drug screening and toxicology studies. This review aims to highlight recent advances of microfluidic-based devices towards a body-on-a-chip concept, exploring their technology and broad applications in the biomedical field.
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spelling Microfluidic Organ/Body-on-a-Chip Devices at the Convergence of Biology and MicroengineeringCirculating tumor-cellsIn-Vitro modelReal-time PcrStem-cellsCancer patientsBreast-cancerGene-expressionLabel-freeCapillary-ElectrophoresisEpithelial-cellsRecent advances in biomedical technologies are mostly related to the convergence of biology with microengineering. For instance, microfluidic devices are now commonly found in most research centers, clinics and hospitals, contributing to more accurate studies and therapies as powerful tools for drug delivery, monitoring of specific analytes, and medical diagnostics. Most remarkably, integration of cellularized constructs within microengineered platforms has enabled the recapitulation of the physiological and pathological conditions of complex tissues and organs. The so-called organ-on-a-chip technology, which represents a new avenue in the field of advanced in vitro models, with the potential to revolutionize current approaches to drug screening and toxicology studies. This review aims to highlight recent advances of microfluidic-based devices towards a body-on-a-chip concept, exploring their technology and broad applications in the biomedical field.European Regional Development Fund-Project FNUSA-ICRC [CZ.1.05/1.1.00/02.0123]; Fundacao para a Ciencia e a Tecnologia (FCT), Portugal [UID/BIM/04773/2013]; Internal Research Grant Program, Universita Campus Bio-Medico di RomaMDPI AgSapientiaPerestrelo, Ana RubinaÁguas, Ana C. P.Rainer, AlbertoForte, Giancarlo2018-12-07T14:52:46Z2015-122015-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.1/11205eng1424-822010.3390/s151229848info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-24T10:22:58Zoai:sapientia.ualg.pt:10400.1/11205Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:02:42.918262Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Microfluidic Organ/Body-on-a-Chip Devices at the Convergence of Biology and Microengineering
title Microfluidic Organ/Body-on-a-Chip Devices at the Convergence of Biology and Microengineering
spellingShingle Microfluidic Organ/Body-on-a-Chip Devices at the Convergence of Biology and Microengineering
Perestrelo, Ana Rubina
Circulating tumor-cells
In-Vitro model
Real-time Pcr
Stem-cells
Cancer patients
Breast-cancer
Gene-expression
Label-free
Capillary-Electrophoresis
Epithelial-cells
title_short Microfluidic Organ/Body-on-a-Chip Devices at the Convergence of Biology and Microengineering
title_full Microfluidic Organ/Body-on-a-Chip Devices at the Convergence of Biology and Microengineering
title_fullStr Microfluidic Organ/Body-on-a-Chip Devices at the Convergence of Biology and Microengineering
title_full_unstemmed Microfluidic Organ/Body-on-a-Chip Devices at the Convergence of Biology and Microengineering
title_sort Microfluidic Organ/Body-on-a-Chip Devices at the Convergence of Biology and Microengineering
author Perestrelo, Ana Rubina
author_facet Perestrelo, Ana Rubina
Águas, Ana C. P.
Rainer, Alberto
Forte, Giancarlo
author_role author
author2 Águas, Ana C. P.
Rainer, Alberto
Forte, Giancarlo
author2_role author
author
author
dc.contributor.none.fl_str_mv Sapientia
dc.contributor.author.fl_str_mv Perestrelo, Ana Rubina
Águas, Ana C. P.
Rainer, Alberto
Forte, Giancarlo
dc.subject.por.fl_str_mv Circulating tumor-cells
In-Vitro model
Real-time Pcr
Stem-cells
Cancer patients
Breast-cancer
Gene-expression
Label-free
Capillary-Electrophoresis
Epithelial-cells
topic Circulating tumor-cells
In-Vitro model
Real-time Pcr
Stem-cells
Cancer patients
Breast-cancer
Gene-expression
Label-free
Capillary-Electrophoresis
Epithelial-cells
description Recent advances in biomedical technologies are mostly related to the convergence of biology with microengineering. For instance, microfluidic devices are now commonly found in most research centers, clinics and hospitals, contributing to more accurate studies and therapies as powerful tools for drug delivery, monitoring of specific analytes, and medical diagnostics. Most remarkably, integration of cellularized constructs within microengineered platforms has enabled the recapitulation of the physiological and pathological conditions of complex tissues and organs. The so-called organ-on-a-chip technology, which represents a new avenue in the field of advanced in vitro models, with the potential to revolutionize current approaches to drug screening and toxicology studies. This review aims to highlight recent advances of microfluidic-based devices towards a body-on-a-chip concept, exploring their technology and broad applications in the biomedical field.
publishDate 2015
dc.date.none.fl_str_mv 2015-12
2015-12-01T00:00:00Z
2018-12-07T14:52:46Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.1/11205
url http://hdl.handle.net/10400.1/11205
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1424-8220
10.3390/s151229848
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI Ag
publisher.none.fl_str_mv MDPI Ag
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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