Effect of Atmospheric Conditions on Pathogenic Phenotypes of Arcobacter butzleri

Detalhes bibliográficos
Autor(a) principal: Martins, Rodrigo
Data de Publicação: 2022
Outros Autores: Mateus, Cristiana, Domingues, Fernanda, Bücker, Roland, Oleastro, Mónica, Ferreira, Susana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/8557
Resumo: This article belongs to the Special Issue Foodborne Pathogens: Infections and Pathogenesis.
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spelling Effect of Atmospheric Conditions on Pathogenic Phenotypes of Arcobacter butzleriAliarcobacter butzleriVirulenceStress ResponseAtmospheric ConditionsGastrointestinal InfectionsInfecções GastrointestinaisThis article belongs to the Special Issue Foodborne Pathogens: Infections and Pathogenesis.Arcobacter butzleri is an emergent gram-negative enteropathogenic bacterium widespread in different environments and hosts. During the colonization of the gastrointestinal tract, bacteria face a variety of environmental conditions to successfully establish infection in a new host. One of these challenges is the fluctuation of oxygen concentrations encountered not only throughout the host gastrointestinal tract and defences but also in the food industry. Oxygen fluctuations can lead to modulations in the virulence of the bacterium and possibly increase its pathogenic potential. In this sense, eight human isolates of A. butzleri were studied to evaluate the effects of microaerobic and aerobic atmospheric conditions in stressful host conditions, such as oxidative stress, acid survival, and human serum survival. In addition, the effects on the modulation of virulence traits, such as haemolytic activity, bacterial motility, biofilm formation ability, and adhesion and invasion of the Caco-2 cell line, were also investigated. Overall, aerobic conditions negatively affected the susceptibility to oxygen reactive species and biofilm formation ability but improved the isolates’ haemolytic ability and motility while other traits showed an isolate-dependent response. In summary, this work demonstrates for the first time that oxygen levels can modulate the potential pathogenicity of A. butzleri, although the response to stressful conditions was very heterogeneous among different strains.This work was developed within the scope of the CICS-UBI projects UIDB/00709/2020 and UIDP/00709/2020, funded by national funds through the Portuguese Foundation for Science and Technology/MCTES.MDPIRepositório Científico do Instituto Nacional de SaúdeMartins, RodrigoMateus, CristianaDomingues, FernandaBücker, RolandOleastro, MónicaFerreira, Susana2023-03-17T15:03:52Z2022-12-062022-12-06T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/8557engMicroorganisms. 2022 Dec 6;10(12):2409. doi: 10.3390/microorganisms101224092076-260710.3390/microorganisms10122409info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:42:37Zoai:repositorio.insa.pt:10400.18/8557Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:43:09.921486Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Effect of Atmospheric Conditions on Pathogenic Phenotypes of Arcobacter butzleri
title Effect of Atmospheric Conditions on Pathogenic Phenotypes of Arcobacter butzleri
spellingShingle Effect of Atmospheric Conditions on Pathogenic Phenotypes of Arcobacter butzleri
Martins, Rodrigo
Aliarcobacter butzleri
Virulence
Stress Response
Atmospheric Conditions
Gastrointestinal Infections
Infecções Gastrointestinais
title_short Effect of Atmospheric Conditions on Pathogenic Phenotypes of Arcobacter butzleri
title_full Effect of Atmospheric Conditions on Pathogenic Phenotypes of Arcobacter butzleri
title_fullStr Effect of Atmospheric Conditions on Pathogenic Phenotypes of Arcobacter butzleri
title_full_unstemmed Effect of Atmospheric Conditions on Pathogenic Phenotypes of Arcobacter butzleri
title_sort Effect of Atmospheric Conditions on Pathogenic Phenotypes of Arcobacter butzleri
author Martins, Rodrigo
author_facet Martins, Rodrigo
Mateus, Cristiana
Domingues, Fernanda
Bücker, Roland
Oleastro, Mónica
Ferreira, Susana
author_role author
author2 Mateus, Cristiana
Domingues, Fernanda
Bücker, Roland
Oleastro, Mónica
Ferreira, Susana
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Martins, Rodrigo
Mateus, Cristiana
Domingues, Fernanda
Bücker, Roland
Oleastro, Mónica
Ferreira, Susana
dc.subject.por.fl_str_mv Aliarcobacter butzleri
Virulence
Stress Response
Atmospheric Conditions
Gastrointestinal Infections
Infecções Gastrointestinais
topic Aliarcobacter butzleri
Virulence
Stress Response
Atmospheric Conditions
Gastrointestinal Infections
Infecções Gastrointestinais
description This article belongs to the Special Issue Foodborne Pathogens: Infections and Pathogenesis.
publishDate 2022
dc.date.none.fl_str_mv 2022-12-06
2022-12-06T00:00:00Z
2023-03-17T15:03:52Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/8557
url http://hdl.handle.net/10400.18/8557
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Microorganisms. 2022 Dec 6;10(12):2409. doi: 10.3390/microorganisms10122409
2076-2607
10.3390/microorganisms10122409
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
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instacron_str RCAAP
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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