Tuning the drug multimodal release through a co-assembly strategy based on magnetic gels
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/1822/78311 |
Resumo: | Self-assembled short peptide-based gels are highly promising drug delivery systems. However, implementing a stimulus often requires screening different structures to obtain gels with suitable properties, and drugs might not be well encapsulated and/or cause undesirable effects on the gel's properties. To overcome this challenge, a new design approach is presented to modulate the release of doxorubicin as a model chemotherapeutic drug through the interplay of (di)phenylalanine-coated magnetic nanoparticles, PEGylated liposomes and doxorubicin co-assembly in dehydropeptide-based gels. The composites enable an enhancement of the gelation kinetics in a concentration-dependent manner, mainly through the use of PEGylated liposomes. The effect of the co-assembly of phenylalanine-coated nanoparticles with the hydrogel displays a concentration and size dependence. Finally, the integration of liposomes as doxorubicin storage units and of nanoparticles as composites that co-assemble with the gel matrix enables the tuneability of both passive and active doxorubicin release through a thermal, and a low-frequency alternating magnetic field-based trigger. In addition to the modulation of the gel properties, the functionalization with (di)phenylalanine improves the cytocompatibility of the nanoparticles. Hereby, this work paves a way for the development of peptide-based supramolecular systems for on-demand and controlled release of drugs. |
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Tuning the drug multimodal release through a co-assembly strategy based on magnetic gelsCiências Naturais::Ciências FísicasScience & TechnologySelf-assembled short peptide-based gels are highly promising drug delivery systems. However, implementing a stimulus often requires screening different structures to obtain gels with suitable properties, and drugs might not be well encapsulated and/or cause undesirable effects on the gel's properties. To overcome this challenge, a new design approach is presented to modulate the release of doxorubicin as a model chemotherapeutic drug through the interplay of (di)phenylalanine-coated magnetic nanoparticles, PEGylated liposomes and doxorubicin co-assembly in dehydropeptide-based gels. The composites enable an enhancement of the gelation kinetics in a concentration-dependent manner, mainly through the use of PEGylated liposomes. The effect of the co-assembly of phenylalanine-coated nanoparticles with the hydrogel displays a concentration and size dependence. Finally, the integration of liposomes as doxorubicin storage units and of nanoparticles as composites that co-assemble with the gel matrix enables the tuneability of both passive and active doxorubicin release through a thermal, and a low-frequency alternating magnetic field-based trigger. In addition to the modulation of the gel properties, the functionalization with (di)phenylalanine improves the cytocompatibility of the nanoparticles. Hereby, this work paves a way for the development of peptide-based supramolecular systems for on-demand and controlled release of drugs.This work was funded by Ministerio de Economia y Competitividad de Espana (PID2020-113704RB-I00 and PID2020-119242RB-I00), Xunta de Galicia (Centro Singular de Investigacion de Galicia - Accreditation 2019-2022 ED431G 2019/06 and IN607A 2018/5 and project ED431C 2020-06,), and European Union (EU-ERDF Interreg V-A - Spain-Portugal 0245_IBEROS_1_E, 0712_ACUINANO_1_E, and 0624_2IQBIONEURO_6_E, and Interreg Atlantic Area NANOCULTURE 1.102.531), and the European Union H2020-MSCA-RISE-2019 PEPSA-MATE project, and by the Portuguese Foundation for Science and Technology (FCT) in the framework of the Strategic Funding of CF-UM-UP (UIDB/04650/2020), IPC (UID/CTM/50025/2020) and CQUM (UIDB/00686/2020). FCT, FEDER, PORTUGAL2020 and COMPETE2020 are also acknowledged for funding under research projects PTDC/QUI-QFI/28020/2017 (POCI-01-0145-FEDER-028020) and PTDC/QUI-QOR/29015/2017 (POCI-01-0145-FEDER-029015). S. R. S. Veloso acknowledges FCT for a PhD grant (SFRH/BD/144017/2019). Support from MAP-Fis Doctoral Programme is also acknowledged.Royal Society of ChemistryUniversidade do MinhoVeloso, Sergio R. S.Tiryaki, EcemSpuch, CarlosHilliou, L.Amorim, C. O.Amaral, V. S.Coutinho, Paulo J. G.Ferreira, Paula M. T.Salgueirino, VeronicaCorrea-Duarte, Miguel A.Castanheira, Elisabete M. S.2022-032022-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://hdl.handle.net/1822/78311engVeloso, S. R. S., Tiryaki, E., Spuch, C., Hilliou, L., Amorim, C. O., Amaral, V. S., … Castanheira, E. M. S. (2022). Tuning the drug multimodal release through a co-assembly strategy based on magnetic gels. Nanoscale. Royal Society of Chemistry (RSC). http://doi.org/10.1039/d1nr08158f2040-336410.1039/d1nr08158f35332904https://pubs.rsc.org/en/content/articlelanding/2022/NR/D1NR08158Finfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:36:47Zoai:repositorium.sdum.uminho.pt:1822/78311Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:32:57.678949Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Tuning the drug multimodal release through a co-assembly strategy based on magnetic gels |
title |
Tuning the drug multimodal release through a co-assembly strategy based on magnetic gels |
spellingShingle |
Tuning the drug multimodal release through a co-assembly strategy based on magnetic gels Veloso, Sergio R. S. Ciências Naturais::Ciências Físicas Science & Technology |
title_short |
Tuning the drug multimodal release through a co-assembly strategy based on magnetic gels |
title_full |
Tuning the drug multimodal release through a co-assembly strategy based on magnetic gels |
title_fullStr |
Tuning the drug multimodal release through a co-assembly strategy based on magnetic gels |
title_full_unstemmed |
Tuning the drug multimodal release through a co-assembly strategy based on magnetic gels |
title_sort |
Tuning the drug multimodal release through a co-assembly strategy based on magnetic gels |
author |
Veloso, Sergio R. S. |
author_facet |
Veloso, Sergio R. S. Tiryaki, Ecem Spuch, Carlos Hilliou, L. Amorim, C. O. Amaral, V. S. Coutinho, Paulo J. G. Ferreira, Paula M. T. Salgueirino, Veronica Correa-Duarte, Miguel A. Castanheira, Elisabete M. S. |
author_role |
author |
author2 |
Tiryaki, Ecem Spuch, Carlos Hilliou, L. Amorim, C. O. Amaral, V. S. Coutinho, Paulo J. G. Ferreira, Paula M. T. Salgueirino, Veronica Correa-Duarte, Miguel A. Castanheira, Elisabete M. S. |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Veloso, Sergio R. S. Tiryaki, Ecem Spuch, Carlos Hilliou, L. Amorim, C. O. Amaral, V. S. Coutinho, Paulo J. G. Ferreira, Paula M. T. Salgueirino, Veronica Correa-Duarte, Miguel A. Castanheira, Elisabete M. S. |
dc.subject.por.fl_str_mv |
Ciências Naturais::Ciências Físicas Science & Technology |
topic |
Ciências Naturais::Ciências Físicas Science & Technology |
description |
Self-assembled short peptide-based gels are highly promising drug delivery systems. However, implementing a stimulus often requires screening different structures to obtain gels with suitable properties, and drugs might not be well encapsulated and/or cause undesirable effects on the gel's properties. To overcome this challenge, a new design approach is presented to modulate the release of doxorubicin as a model chemotherapeutic drug through the interplay of (di)phenylalanine-coated magnetic nanoparticles, PEGylated liposomes and doxorubicin co-assembly in dehydropeptide-based gels. The composites enable an enhancement of the gelation kinetics in a concentration-dependent manner, mainly through the use of PEGylated liposomes. The effect of the co-assembly of phenylalanine-coated nanoparticles with the hydrogel displays a concentration and size dependence. Finally, the integration of liposomes as doxorubicin storage units and of nanoparticles as composites that co-assemble with the gel matrix enables the tuneability of both passive and active doxorubicin release through a thermal, and a low-frequency alternating magnetic field-based trigger. In addition to the modulation of the gel properties, the functionalization with (di)phenylalanine improves the cytocompatibility of the nanoparticles. Hereby, this work paves a way for the development of peptide-based supramolecular systems for on-demand and controlled release of drugs. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-03 2022-03-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/1822/78311 |
url |
https://hdl.handle.net/1822/78311 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Veloso, S. R. S., Tiryaki, E., Spuch, C., Hilliou, L., Amorim, C. O., Amaral, V. S., … Castanheira, E. M. S. (2022). Tuning the drug multimodal release through a co-assembly strategy based on magnetic gels. Nanoscale. Royal Society of Chemistry (RSC). http://doi.org/10.1039/d1nr08158f 2040-3364 10.1039/d1nr08158f 35332904 https://pubs.rsc.org/en/content/articlelanding/2022/NR/D1NR08158F |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Royal Society of Chemistry |
publisher.none.fl_str_mv |
Royal Society of Chemistry |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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