Labial lesion in a Portuguese man returned from Brazil - The role of molecular diagnosis
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.18/5095 |
Resumo: | Paracoccidioidomycosis is an acute - to chronic systemic mycosis caused by the fungus Paracoccidioides. Two species are recognized as causing paracoccidioidomycosis: Paracoccidioides brasiliensis and Paracoccidioides lutzii. Paracoccidioidomycosis is a commonly diagnosed fungal infection in South America and rare in Europe. Nevertheless, with the increase of immigration from endemic regions to European countries, clinicians must be aware of tropical infections and strongly consider them in differential diagnosis, having therefore the knowledge of all the available means necessary to identify specific pathogens. The authors present a case report of a Portuguese 46-year-old man who lived in Itaipava-Brazil for the past 21 years. In his return to Portugal, presented a lip lesion, weight loss, pulmonary infiltrates and cavities, and generalized adenopathies. An histopatologic diagnosis of mucocutaneous and pulmonary cryptococcosis was initially made. However, the negative result of cryptococcal antigen and the patient's epidemiology lead to the hypothesis of other etiological agent. All cultural examinations were negative, however the molecular detection of fungal DNA directly from tissue samples allowed the identification of the correct etiological agent as Paracoccidioides brasiliensis and the introduction of a most effective treatment for the management of this fungal infection. This was the first time that Paracoccidioides brasiliensis was identified by this PCR technique in Portugal. |
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Labial lesion in a Portuguese man returned from Brazil - The role of molecular diagnosisParacoccidioidomycosisPolymerase Chain ReactionHuman MigrationPorttugalInfecções Sistémicas e ZoonosesParacoccidioidomycosis is an acute - to chronic systemic mycosis caused by the fungus Paracoccidioides. Two species are recognized as causing paracoccidioidomycosis: Paracoccidioides brasiliensis and Paracoccidioides lutzii. Paracoccidioidomycosis is a commonly diagnosed fungal infection in South America and rare in Europe. Nevertheless, with the increase of immigration from endemic regions to European countries, clinicians must be aware of tropical infections and strongly consider them in differential diagnosis, having therefore the knowledge of all the available means necessary to identify specific pathogens. The authors present a case report of a Portuguese 46-year-old man who lived in Itaipava-Brazil for the past 21 years. In his return to Portugal, presented a lip lesion, weight loss, pulmonary infiltrates and cavities, and generalized adenopathies. An histopatologic diagnosis of mucocutaneous and pulmonary cryptococcosis was initially made. However, the negative result of cryptococcal antigen and the patient's epidemiology lead to the hypothesis of other etiological agent. All cultural examinations were negative, however the molecular detection of fungal DNA directly from tissue samples allowed the identification of the correct etiological agent as Paracoccidioides brasiliensis and the introduction of a most effective treatment for the management of this fungal infection. This was the first time that Paracoccidioides brasiliensis was identified by this PCR technique in Portugal.ElsevierRepositório Científico do Instituto Nacional de SaúdeFerreira, AntónioSilva, AugustaCruz, MarianaSabino, RaquelVeríssimo, Cristina2019-12-01T01:30:13Z2018-032018-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/5095engTravel Med Infect Dis. 2018 Mar - Apr;22:80-81. doi: 10.1016/j.tmaid.2017.12.001. Epub 2017 Dec 6.1477-893910.1016/j.tmaid.2017.12.001info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:40:39Zoai:repositorio.insa.pt:10400.18/5095Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:39:48.908607Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Labial lesion in a Portuguese man returned from Brazil - The role of molecular diagnosis |
title |
Labial lesion in a Portuguese man returned from Brazil - The role of molecular diagnosis |
spellingShingle |
Labial lesion in a Portuguese man returned from Brazil - The role of molecular diagnosis Ferreira, António Paracoccidioidomycosis Polymerase Chain Reaction Human Migration Porttugal Infecções Sistémicas e Zoonoses |
title_short |
Labial lesion in a Portuguese man returned from Brazil - The role of molecular diagnosis |
title_full |
Labial lesion in a Portuguese man returned from Brazil - The role of molecular diagnosis |
title_fullStr |
Labial lesion in a Portuguese man returned from Brazil - The role of molecular diagnosis |
title_full_unstemmed |
Labial lesion in a Portuguese man returned from Brazil - The role of molecular diagnosis |
title_sort |
Labial lesion in a Portuguese man returned from Brazil - The role of molecular diagnosis |
author |
Ferreira, António |
author_facet |
Ferreira, António Silva, Augusta Cruz, Mariana Sabino, Raquel Veríssimo, Cristina |
author_role |
author |
author2 |
Silva, Augusta Cruz, Mariana Sabino, Raquel Veríssimo, Cristina |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
dc.contributor.author.fl_str_mv |
Ferreira, António Silva, Augusta Cruz, Mariana Sabino, Raquel Veríssimo, Cristina |
dc.subject.por.fl_str_mv |
Paracoccidioidomycosis Polymerase Chain Reaction Human Migration Porttugal Infecções Sistémicas e Zoonoses |
topic |
Paracoccidioidomycosis Polymerase Chain Reaction Human Migration Porttugal Infecções Sistémicas e Zoonoses |
description |
Paracoccidioidomycosis is an acute - to chronic systemic mycosis caused by the fungus Paracoccidioides. Two species are recognized as causing paracoccidioidomycosis: Paracoccidioides brasiliensis and Paracoccidioides lutzii. Paracoccidioidomycosis is a commonly diagnosed fungal infection in South America and rare in Europe. Nevertheless, with the increase of immigration from endemic regions to European countries, clinicians must be aware of tropical infections and strongly consider them in differential diagnosis, having therefore the knowledge of all the available means necessary to identify specific pathogens. The authors present a case report of a Portuguese 46-year-old man who lived in Itaipava-Brazil for the past 21 years. In his return to Portugal, presented a lip lesion, weight loss, pulmonary infiltrates and cavities, and generalized adenopathies. An histopatologic diagnosis of mucocutaneous and pulmonary cryptococcosis was initially made. However, the negative result of cryptococcal antigen and the patient's epidemiology lead to the hypothesis of other etiological agent. All cultural examinations were negative, however the molecular detection of fungal DNA directly from tissue samples allowed the identification of the correct etiological agent as Paracoccidioides brasiliensis and the introduction of a most effective treatment for the management of this fungal infection. This was the first time that Paracoccidioides brasiliensis was identified by this PCR technique in Portugal. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-03 2018-03-01T00:00:00Z 2019-12-01T01:30:13Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/5095 |
url |
http://hdl.handle.net/10400.18/5095 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Travel Med Infect Dis. 2018 Mar - Apr;22:80-81. doi: 10.1016/j.tmaid.2017.12.001. Epub 2017 Dec 6. 1477-8939 10.1016/j.tmaid.2017.12.001 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/embargoedAccess |
eu_rights_str_mv |
embargoedAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799132138464870400 |