Longitudinal analysis of viral shedding in astronauts before, during, and after a mission to the International Space Station

Detalhes bibliográficos
Autor(a) principal: Moreira, Frederico José Santos Mota de Oliveira
Data de Publicação: 2022
Tipo de documento: Dissertação
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/54733
Resumo: Trabalho de Projeto de Mestrado, Bioestatística, 2022, Universidade de Lisboa, Faculdade de Ciências
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spelling Longitudinal analysis of viral shedding in astronauts before, during, and after a mission to the International Space StationMissing dataMultiple imputation based on chained equationsCategorical data analysis with missing responsesLongitudinal modelsTeses de mestrado - 2022Domínio/Área Científica::Ciências Naturais::MatemáticasTrabalho de Projeto de Mestrado, Bioestatística, 2022, Universidade de Lisboa, Faculdade de CiênciasHerpesviruses were measured in 23 astronauts with the objective of understanding their reactivation pattern during a long-duration space mission. The measurements consisted of the number of viral copies of cytomegalovirus (CMV), Epstein-Barr (EBV) and varicella-zoster (VZV) viruses collected at different moments: two before (L−180, L−45 ), three during (Early, Mid, Late) and two after (R+0, R+30 ) a spaceflight. These data present three difficulties: small sample size, zero-inflation and missing responses. The methods used were confidence intervals for proportions, McNemar’s exact test, linear models for categorical data, multiple imputation using chained equations (MICE), and logistic regression mixed models (LRMM). CMV was only measured once during the flight (During). There was significant increase in the reactivation proportion during flight compared to before and after flight measures L−180 and R+30. The LRMM fitted for binary CMV that had moments with reactivation as fixed effects and random effect subject was significant at coefficient R+30 (p=0.043), although During (p=0.078) had a p-value close to the statistical significance of 5%. EBV and VZV were measured in saliva samples and have missing responses for the inflight moments. An increase of the amplitude of reactivation was detected at Late for both viruses. The data seemed to follow a missing-completely-at-random mechanism for both viruses (p=0.490 and 0.070 for EBV and VZV, respectively). Fifty imputed data sets were generated for each virus. For EBV the pooled estimates for the reactivation probability were 0.126, 0.239, 0.454 for Early, Mid, Late, respectively, and for VZV 0.488, 0.330, 0.617, respectively. The pooled LRMM of EBV with L−180 as baseline was significant at L−45 (p=0.029) and Late (p=0.022), and R+0 (p=0.053) was close to significance. For VZV, R+30 was the only significant different from baseline Early(p=0.002). In conclusion, the stress conditions of the spaceflight affected the reactivation dynamics of all three viruses.Sepúlveda, NunoAntunes, Marília Cristina de SousaRepositório da Universidade de LisboaMoreira, Frederico José Santos Mota de Oliveira2022-10-10T17:31:09Z202220222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10451/54733enginfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:01:19Zoai:repositorio.ul.pt:10451/54733Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:05:30.854487Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Longitudinal analysis of viral shedding in astronauts before, during, and after a mission to the International Space Station
title Longitudinal analysis of viral shedding in astronauts before, during, and after a mission to the International Space Station
spellingShingle Longitudinal analysis of viral shedding in astronauts before, during, and after a mission to the International Space Station
Moreira, Frederico José Santos Mota de Oliveira
Missing data
Multiple imputation based on chained equations
Categorical data analysis with missing responses
Longitudinal models
Teses de mestrado - 2022
Domínio/Área Científica::Ciências Naturais::Matemáticas
title_short Longitudinal analysis of viral shedding in astronauts before, during, and after a mission to the International Space Station
title_full Longitudinal analysis of viral shedding in astronauts before, during, and after a mission to the International Space Station
title_fullStr Longitudinal analysis of viral shedding in astronauts before, during, and after a mission to the International Space Station
title_full_unstemmed Longitudinal analysis of viral shedding in astronauts before, during, and after a mission to the International Space Station
title_sort Longitudinal analysis of viral shedding in astronauts before, during, and after a mission to the International Space Station
author Moreira, Frederico José Santos Mota de Oliveira
author_facet Moreira, Frederico José Santos Mota de Oliveira
author_role author
dc.contributor.none.fl_str_mv Sepúlveda, Nuno
Antunes, Marília Cristina de Sousa
Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Moreira, Frederico José Santos Mota de Oliveira
dc.subject.por.fl_str_mv Missing data
Multiple imputation based on chained equations
Categorical data analysis with missing responses
Longitudinal models
Teses de mestrado - 2022
Domínio/Área Científica::Ciências Naturais::Matemáticas
topic Missing data
Multiple imputation based on chained equations
Categorical data analysis with missing responses
Longitudinal models
Teses de mestrado - 2022
Domínio/Área Científica::Ciências Naturais::Matemáticas
description Trabalho de Projeto de Mestrado, Bioestatística, 2022, Universidade de Lisboa, Faculdade de Ciências
publishDate 2022
dc.date.none.fl_str_mv 2022-10-10T17:31:09Z
2022
2022
2022-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/54733
url http://hdl.handle.net/10451/54733
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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