Longitudinal analysis of viral shedding in astronauts before, during, and after a mission to the International Space Station
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Tipo de documento: | Dissertação |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/54733 |
Resumo: | Trabalho de Projeto de Mestrado, Bioestatística, 2022, Universidade de Lisboa, Faculdade de Ciências |
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Longitudinal analysis of viral shedding in astronauts before, during, and after a mission to the International Space StationMissing dataMultiple imputation based on chained equationsCategorical data analysis with missing responsesLongitudinal modelsTeses de mestrado - 2022Domínio/Área Científica::Ciências Naturais::MatemáticasTrabalho de Projeto de Mestrado, Bioestatística, 2022, Universidade de Lisboa, Faculdade de CiênciasHerpesviruses were measured in 23 astronauts with the objective of understanding their reactivation pattern during a long-duration space mission. The measurements consisted of the number of viral copies of cytomegalovirus (CMV), Epstein-Barr (EBV) and varicella-zoster (VZV) viruses collected at different moments: two before (L−180, L−45 ), three during (Early, Mid, Late) and two after (R+0, R+30 ) a spaceflight. These data present three difficulties: small sample size, zero-inflation and missing responses. The methods used were confidence intervals for proportions, McNemar’s exact test, linear models for categorical data, multiple imputation using chained equations (MICE), and logistic regression mixed models (LRMM). CMV was only measured once during the flight (During). There was significant increase in the reactivation proportion during flight compared to before and after flight measures L−180 and R+30. The LRMM fitted for binary CMV that had moments with reactivation as fixed effects and random effect subject was significant at coefficient R+30 (p=0.043), although During (p=0.078) had a p-value close to the statistical significance of 5%. EBV and VZV were measured in saliva samples and have missing responses for the inflight moments. An increase of the amplitude of reactivation was detected at Late for both viruses. The data seemed to follow a missing-completely-at-random mechanism for both viruses (p=0.490 and 0.070 for EBV and VZV, respectively). Fifty imputed data sets were generated for each virus. For EBV the pooled estimates for the reactivation probability were 0.126, 0.239, 0.454 for Early, Mid, Late, respectively, and for VZV 0.488, 0.330, 0.617, respectively. The pooled LRMM of EBV with L−180 as baseline was significant at L−45 (p=0.029) and Late (p=0.022), and R+0 (p=0.053) was close to significance. For VZV, R+30 was the only significant different from baseline Early(p=0.002). In conclusion, the stress conditions of the spaceflight affected the reactivation dynamics of all three viruses.Sepúlveda, NunoAntunes, Marília Cristina de SousaRepositório da Universidade de LisboaMoreira, Frederico José Santos Mota de Oliveira2022-10-10T17:31:09Z202220222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10451/54733enginfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:01:19Zoai:repositorio.ul.pt:10451/54733Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:05:30.854487Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Longitudinal analysis of viral shedding in astronauts before, during, and after a mission to the International Space Station |
title |
Longitudinal analysis of viral shedding in astronauts before, during, and after a mission to the International Space Station |
spellingShingle |
Longitudinal analysis of viral shedding in astronauts before, during, and after a mission to the International Space Station Moreira, Frederico José Santos Mota de Oliveira Missing data Multiple imputation based on chained equations Categorical data analysis with missing responses Longitudinal models Teses de mestrado - 2022 Domínio/Área Científica::Ciências Naturais::Matemáticas |
title_short |
Longitudinal analysis of viral shedding in astronauts before, during, and after a mission to the International Space Station |
title_full |
Longitudinal analysis of viral shedding in astronauts before, during, and after a mission to the International Space Station |
title_fullStr |
Longitudinal analysis of viral shedding in astronauts before, during, and after a mission to the International Space Station |
title_full_unstemmed |
Longitudinal analysis of viral shedding in astronauts before, during, and after a mission to the International Space Station |
title_sort |
Longitudinal analysis of viral shedding in astronauts before, during, and after a mission to the International Space Station |
author |
Moreira, Frederico José Santos Mota de Oliveira |
author_facet |
Moreira, Frederico José Santos Mota de Oliveira |
author_role |
author |
dc.contributor.none.fl_str_mv |
Sepúlveda, Nuno Antunes, Marília Cristina de Sousa Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Moreira, Frederico José Santos Mota de Oliveira |
dc.subject.por.fl_str_mv |
Missing data Multiple imputation based on chained equations Categorical data analysis with missing responses Longitudinal models Teses de mestrado - 2022 Domínio/Área Científica::Ciências Naturais::Matemáticas |
topic |
Missing data Multiple imputation based on chained equations Categorical data analysis with missing responses Longitudinal models Teses de mestrado - 2022 Domínio/Área Científica::Ciências Naturais::Matemáticas |
description |
Trabalho de Projeto de Mestrado, Bioestatística, 2022, Universidade de Lisboa, Faculdade de Ciências |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-10-10T17:31:09Z 2022 2022 2022-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/54733 |
url |
http://hdl.handle.net/10451/54733 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799134607168241664 |