Salvia ceratophylla L. from South of Jordan: new insights on chemical composition and biological activities
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/106496 https://doi.org/10.1007/s13659-020-00259-9 |
Resumo: | In Jordan, Salvia ceratophylla L. is traditionally used in the treatment of cancer, microbial infections, and urinary disorders. This study aimed: (1) to chemically characterize S. ceratophylla essential oil (EO) from South Jordan, by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS); and (2) to evaluate in vitro the cytotoxic, anti-inflammatory, and antiprotozoal activities of the EO, it's predominant components, and the hexane (A), ethyl acetate (B), methanol (C) and crude-methanol extracts (D). The analysis revealed that the EO has 71 compounds, with linalool (54.8%) as main constituent. Only the hexane extract (A) showed some cytotoxic activity against SK-MEL, KB, BT-549, SK-OV-3, LLC-PK1 and VERO cells lines with IC50 between 60 and > 100 µg/mL. The EO inhibited NO production (IC50 90 µg/mL) and NF-κB activity (IC50 38 µg/mL). The extracts A, B, and D inhibited NO production and NF- κB activity with IC50 between 32 and 150 µg/mL. Linalool considerably inhibited NO production (IC50 18 µg/mL). The extracts tested did not exhibit antileishmanial activity. Regarding antitrypanosomal activity, the EO exhibited significant results with IC50 2.65 µg/mL. In conclusion, Jordan S. ceratophylla EO represents a rich source of linalool and bears a promising therapeutic potential for further antitrypanosomal drug development. |
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Salvia ceratophylla L. from South of Jordan: new insights on chemical composition and biological activitiesLamiaceaeEssential oilChemical compositionCytotoxicityAnti-inflammatory activityNeglected diseasesIn Jordan, Salvia ceratophylla L. is traditionally used in the treatment of cancer, microbial infections, and urinary disorders. This study aimed: (1) to chemically characterize S. ceratophylla essential oil (EO) from South Jordan, by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS); and (2) to evaluate in vitro the cytotoxic, anti-inflammatory, and antiprotozoal activities of the EO, it's predominant components, and the hexane (A), ethyl acetate (B), methanol (C) and crude-methanol extracts (D). The analysis revealed that the EO has 71 compounds, with linalool (54.8%) as main constituent. Only the hexane extract (A) showed some cytotoxic activity against SK-MEL, KB, BT-549, SK-OV-3, LLC-PK1 and VERO cells lines with IC50 between 60 and > 100 µg/mL. The EO inhibited NO production (IC50 90 µg/mL) and NF-κB activity (IC50 38 µg/mL). The extracts A, B, and D inhibited NO production and NF- κB activity with IC50 between 32 and 150 µg/mL. Linalool considerably inhibited NO production (IC50 18 µg/mL). The extracts tested did not exhibit antileishmanial activity. Regarding antitrypanosomal activity, the EO exhibited significant results with IC50 2.65 µg/mL. In conclusion, Jordan S. ceratophylla EO represents a rich source of linalool and bears a promising therapeutic potential for further antitrypanosomal drug development.This work has been conducted during the Fulbright visiting scholarship awarded to Prof. Dr. Mohammad Sanad Abu-Darwish during his Sabbatical leave from Al-Balqa’ Applied University, Al-Salt, Jordan, at the National Center for Natural Products Research, School of Pharmacy, University of Mississippi, USA. The authors thank the Dean of Scientific Research, Al-Balqa Applied University, Jordan, the Binational Fulbright Commission in Jordan, Council for International Exchange of Scholars (CIES), and Institute of International Education (IIE), USA. This work was also supported by Foundation for Science and Technology (FCT), Portugal (Strategic Projects UID/NEU/04539/2013 ,and UID/NEU/04539/2019, UIDB/04539/2020 and UIDP/04539/2020 (CIBB)).Springer Nature2020-10info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/106496http://hdl.handle.net/10316/106496https://doi.org/10.1007/s13659-020-00259-9eng2192-219532852722Abu-Darwish, Mohammad SanadCabral, CéliaAli, ZulfigarWang, MeiKhan, Shabana I.Jacob, Melissa R.Jain, Surendra K.Tekwani, Babu L.Zulfiqar, FazilaKhan, Ikhlas A.Taifour, HatemSalgueiro, LígiaEfferth, Thomasinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-04-06T10:20:07Zoai:estudogeral.uc.pt:10316/106496Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:22:56.656481Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Salvia ceratophylla L. from South of Jordan: new insights on chemical composition and biological activities |
title |
Salvia ceratophylla L. from South of Jordan: new insights on chemical composition and biological activities |
spellingShingle |
Salvia ceratophylla L. from South of Jordan: new insights on chemical composition and biological activities Abu-Darwish, Mohammad Sanad Lamiaceae Essential oil Chemical composition Cytotoxicity Anti-inflammatory activity Neglected diseases |
title_short |
Salvia ceratophylla L. from South of Jordan: new insights on chemical composition and biological activities |
title_full |
Salvia ceratophylla L. from South of Jordan: new insights on chemical composition and biological activities |
title_fullStr |
Salvia ceratophylla L. from South of Jordan: new insights on chemical composition and biological activities |
title_full_unstemmed |
Salvia ceratophylla L. from South of Jordan: new insights on chemical composition and biological activities |
title_sort |
Salvia ceratophylla L. from South of Jordan: new insights on chemical composition and biological activities |
author |
Abu-Darwish, Mohammad Sanad |
author_facet |
Abu-Darwish, Mohammad Sanad Cabral, Célia Ali, Zulfigar Wang, Mei Khan, Shabana I. Jacob, Melissa R. Jain, Surendra K. Tekwani, Babu L. Zulfiqar, Fazila Khan, Ikhlas A. Taifour, Hatem Salgueiro, Lígia Efferth, Thomas |
author_role |
author |
author2 |
Cabral, Célia Ali, Zulfigar Wang, Mei Khan, Shabana I. Jacob, Melissa R. Jain, Surendra K. Tekwani, Babu L. Zulfiqar, Fazila Khan, Ikhlas A. Taifour, Hatem Salgueiro, Lígia Efferth, Thomas |
author2_role |
author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Abu-Darwish, Mohammad Sanad Cabral, Célia Ali, Zulfigar Wang, Mei Khan, Shabana I. Jacob, Melissa R. Jain, Surendra K. Tekwani, Babu L. Zulfiqar, Fazila Khan, Ikhlas A. Taifour, Hatem Salgueiro, Lígia Efferth, Thomas |
dc.subject.por.fl_str_mv |
Lamiaceae Essential oil Chemical composition Cytotoxicity Anti-inflammatory activity Neglected diseases |
topic |
Lamiaceae Essential oil Chemical composition Cytotoxicity Anti-inflammatory activity Neglected diseases |
description |
In Jordan, Salvia ceratophylla L. is traditionally used in the treatment of cancer, microbial infections, and urinary disorders. This study aimed: (1) to chemically characterize S. ceratophylla essential oil (EO) from South Jordan, by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS); and (2) to evaluate in vitro the cytotoxic, anti-inflammatory, and antiprotozoal activities of the EO, it's predominant components, and the hexane (A), ethyl acetate (B), methanol (C) and crude-methanol extracts (D). The analysis revealed that the EO has 71 compounds, with linalool (54.8%) as main constituent. Only the hexane extract (A) showed some cytotoxic activity against SK-MEL, KB, BT-549, SK-OV-3, LLC-PK1 and VERO cells lines with IC50 between 60 and > 100 µg/mL. The EO inhibited NO production (IC50 90 µg/mL) and NF-κB activity (IC50 38 µg/mL). The extracts A, B, and D inhibited NO production and NF- κB activity with IC50 between 32 and 150 µg/mL. Linalool considerably inhibited NO production (IC50 18 µg/mL). The extracts tested did not exhibit antileishmanial activity. Regarding antitrypanosomal activity, the EO exhibited significant results with IC50 2.65 µg/mL. In conclusion, Jordan S. ceratophylla EO represents a rich source of linalool and bears a promising therapeutic potential for further antitrypanosomal drug development. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-10 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/106496 http://hdl.handle.net/10316/106496 https://doi.org/10.1007/s13659-020-00259-9 |
url |
http://hdl.handle.net/10316/106496 https://doi.org/10.1007/s13659-020-00259-9 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2192-2195 32852722 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Springer Nature |
publisher.none.fl_str_mv |
Springer Nature |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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